US7157570B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Human ribonucleotide reductase M2 subunit
Assignee: Individual
•
Filing: 2003-03-25
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Granted: 2007-01-02
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Expires: 2023-03-25
Abstract
Abstract An isolated nucleic acid containing a human ribonucleotide reductase M2 subunit promoter sequence or genomic sequence. Also disclosed are methods of determining whether a subject is suffering from or at risk for developing a cell proliferation-associated disorder, identifying a compound for treating a cell proliferation-associated disorder, treating a cell proliferation-associated disorder, and developing a procedure for treating a cell proliferation-associated disorder.
Inventors
- 👤 Yun Yen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 03:25
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0093; A; A61; A61P; A61P35/00; C12N15/00; C12N15/09; C12N15/11; C12Q; C12Q1/00; C12Q1/68; C12Q1/6876; C12Q1/6883; A61K; A61K38/00; C12Q2600/00; C12Q2600/136
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:2, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 2
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:2, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 3
Dependent Claim
18 words
The recombinant isolated nucleic acid of claim 1 , wherein the heterologous nucleotide sequence encodes a reporter protein.
Claim 4
Dependent Claim
23 words
The recombinant isolated nucleic acid of claim 2 , wherein the reporter protein is alkaline phosphatase, horseradish peroxidase, luciferase, β-glactosidase, GFP, or BFP.
Claim 5
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:3, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 6
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:3, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 7
Dependent Claim
18 words
The recombinant isolated nucleic acid of claim 4 , wherein the heterologous nucleotide sequence encodes a reporter protein.
Claim 8
Dependent Claim
23 words
The recombinant isolated nucleic acid of claim 5 , wherein the reporter protein is alkaline phosphatase, horseradish peroxidase, luciferase, β-glactosidase, GFP, or BFP.
Claim 9
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:4, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 10
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:4, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 11
Dependent Claim
18 words
The recombinant isolated nucleic acid of claim 7 , wherein the heterologous nucleotide sequence encodes a reporter protein.
Claim 12
Dependent Claim
23 words
The recombinant isolated nucleic acid of claim 8 , wherein the reporter protein is alkaline phosphatase, horseradish peroxidase, luciferase, β-glactosidase, GFP, or BFP.
Claim 13
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:1, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 14
Dependent Claim
35 words
A recombinant isolated nucleic acid comprising: a hRPM2 promoter sequence consisting of SEQ ID NO:1, and a heterologous nucleotide sequence encoding a transcript, wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Claim 15
Dependent Claim
18 words
The recombinant isolated nucleic acid of claim 10 , wherein the heterologous nucleotide sequence encodes a reporter protein.
Claim 16
Dependent Claim
23 words
The recombinant isolated nucleic acid of claim 11 , wherein the reporter protein is alkaline phosphatase, horseradish peroxidase, luciferase, β-glactosidase, GFP, or BFP.
References Cited (Backward Citations)
US6812339B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2010-01-01 | 2010-07-03 | 2011-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2014-01-01 | 2014-07-03 | 2015-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2018-01-01 | 2018-07-03 | 2019-01-02 | $7700.00 | Window Closed / Lapsed |