US7093482B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
System and method for detecting particles
Assignee: Becton Dickinson and Co
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Filing: 2005-11-04
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Granted: 2006-08-22
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Expires: 2025-11-04
Abstract
Abstract An acoustic detector based on rupture event scanning (“REVS”) with a detection setup allowing the monitoring of REVS signals near the driving frequency and with optimized impedance matching between the REVS crystal and the front-end of the detection circuitry for use in detecting the presence of particles such as bacteria, viruses, or other particulates in liquid samples with extreme high sensitivity.
Inventors
- 👤 Klaus W. Berndt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:26
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/70
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
155 words
A detector for use in detecting the presence of particles in a liquid sample comprising: a signal generator adapted to provide a driving signal to a transient signal isolation circuit, said transient signal isolation circuit comprising a resonant piezo-electric body, an attenuator and phase shifter circuit, a first signal splitting device for directing said transient signal from said signal generator to said resonant piezo-electric body and to said attenuator and phase shifter circuit, and a comparator adapted to receive a first input signal from said resonant piezo-electric body and a second input signal from said attenuator and phase shifter circuit, wherein said comparator generates an output signal based on said first and second input signals, and wherein said resonant piezo-electric body is in contact with said liquid sample; a transient signal detector adapted to receive said output signal of said comparator and to provide a transient detection signal based on said output of said comparator.
Claim 2
Dependent Claim
155 words
A detector for use in detecting the presence of particles in a liquid sample comprising: a signal generator adapted to provide a driving signal to a transient signal isolation circuit, said transient signal isolation circuit comprising a resonant piezo-electric body, an attenuator and phase shifter circuit, a first signal splitting device for directing said transient signal from said signal generator to said resonant piezo-electric body and to said attenuator and phase shifter circuit, and a comparator adapted to receive a first input signal from said resonant piezo-electric body and a second input signal from said attenuator and phase shifter circuit, wherein said comparator generates an output signal based on said first and second input signals, and wherein said resonant piezo-electric body is in contact with said liquid sample; a transient signal detector adapted to receive said output signal of said comparator and to provide a transient detection signal based on said output of said comparator.
Claim 3
Dependent Claim
23 words
A detector as in claim 1 , wherein said resonant piezo-electric body and said attenuator and phase shifter circuit are connected in parallel.
Claim 4
Dependent Claim
22 words
A detector as in claim 1 , wherein said attenuation and phase shifter circuit is adapted to be controlled by a computer.
Claim 5
Dependent Claim
33 words
A detector as in claim 1 , wherein said signal generator is adapted to be controlled by a computer, and wherein said transient signal detector provides, said transient detection signal to said computer.
Claim 6
Dependent Claim
26 words
A detector as in claim 1 , wherein said signal generator is adapted to generate signals selected from the group consisting of RF, sinusoidal and non-sinusoidal.
Claim 7
Dependent Claim
13 words
A detector as in claim 1 , wherein said comparator comprises a transformer.
Claim 8
Dependent Claim
33 words
A detector as in claim 1 , wherein said comparator comprises a first resistor and a second resistor connected in series between said resonant piezo-electric body and said attenuation and phase shifter circuit.
Claim 9
Dependent Claim
24 words
A detector as in claim 7 , wherein said input of said comparator is connected to a node between said first and second resistors.
Claim 10
Dependent Claim
17 words
A detector as in claim 7 , wherein said first and second resistor have substantially equivalent resistance.
Claim 11
Dependent Claim
15 words
A detector as in claim 9 , wherein said resistance is between 10Ω and 1000Ω.
Claim 12
Dependent Claim
16 words
A detector as in claim 9 , wherein said resistance is between 100Ω and 10 kΩ.
Claim 13
Dependent Claim
36 words
A detector as in claim 1 , wherein said comparator comprises a differential amplifier having a first input connected to said resonant piezo-electric body and a second input connected to said attenuation and phase shifter circuit.
Claim 14
Dependent Claim
31 words
A detector as in claim 1 , wherein said resonant piezo-electric body comprises a resonant crystal selected from the group consisting of a piezo-electric crystal and a surface acoustic wave device.
Claim 15
Dependent Claim
38 words
A detector as in claim 4 , wherein said transient signal detector is adapted to receive said transient detection signal and to provide said transient detection signal to said computer if said transient detection signal exceeds a threshold.
Claim 16
Dependent Claim
20 words
A detector as in claim 4 , wherein said transient signal detector is implemented as software running on said computer.
Claim 17
Dependent Claim
15 words
A detector as in claim 1 , wherein said transient signal detector threshold is adjustable.
Claim 18
Dependent Claim
29 words
A detector as in claim 1 , wherein said transient signal detector is adapted to generate a transient detection signal that is proportional to said output of said comparator.
Claim 19
Dependent Claim
19 words
A detector as in claim 1 , wherein said transient signal detector comprises a lock-in amplifier with harmonics capability.
Claim 20
Dependent Claim
17 words
A detector as in claim 1 , wherein said transient signal detector generates output in digital formal.
Claim 21
Dependent Claim
17 words
A detector as in claim 1 , wherein said transient signal detector generates output in analog format.
Claim 22
Dependent Claim
16 words
A detector as in claim 1 , wherein said transient signal detector is a synchronous detector.
Claim 23
Dependent Claim
15 words
A detector as in claim 21 , wherein said synchronous detector is a lock-in amplifier.
Claim 24
Dependent Claim
25 words
A detector as in claim 1 , wherein said piezo-electric body comprises at least one surface capable of binding to particles in a liquid sample.
Claim 25
Dependent Claim
20 words
A detector as in claim 23 , wherein said particles are selected from the group consisting of bacteria and viruses.
Claim 26
Dependent Claim
15 words
A detector as in claim 23 , wherein said at least one surface comprises antibodies.
Claim 27
Dependent Claim
18 words
A detector as in claim 23 , wherein said particles comprise particles capable of causing disease in humans.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2009-08-21 | 2010-02-20 | 2010-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2013-08-21 | 2014-02-20 | 2014-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2017-08-21 | 2018-02-20 | 2018-08-22 | $7700.00 | Window Closed / Lapsed |