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US6841150B2
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Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Assignee: Cognate Bioservices Inc
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Filing: 2002-04-18
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Granted: 2005-01-11
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Expires: 2022-04-18
Abstract
Abstract Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
Inventors
- 👤 Yuan-Di C. Halvorsen
- 👤 William O. Wilkison
- 👤 Jeffrey Martin Gimble
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:08
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0652; C12N5/0655; A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61L27/3839; A61L27/3843; A61L27/3852; A61P; A61P19/00; A61P19/04; A61P19/08; C12N5/0653; A61K; A61K35/00; A61K35/12; A61L2430/00; A61L2430/06; C12N2500/00; C12N2500/30; C12N2500/38; C12N2500/98; C12N2501/00; C12N2501/30; C12N2501/38; C12N2501/39; C12N2501/999; C12N2502/00; C12N2502/13; C12N2502/1305; C12N2506/00; C12N2506/13; C12N2506/1346; C12N2506/1384; C12N2533/00; C12N2533/70; C12N2533/74
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
41 words
A method of treating a cartilage defect in a mammal, the method comprising: a) differentiating an isolated human adipose tissue derived stromal cell into a chondrocytic cell; and b) administering said chondrocytic cell to a cartilage defect area in a mammal.
Claim 2
Independent Claim
41 words
A method of treating a cartilage defect in a mammal, the method comprising: a) differentiating an isolated human adipose tissue derived stromal cell into a chondrocytic cell; and b) administering said chondrocytic cell to a cartilage defect area in a mammal.
Claim 3
Dependent Claim
14 words
The method of claim 1 , wherein said cell further comprises a biocompatible matrix.
Claim 4
Dependent Claim
23 words
The method of claim 2 , wherein said biocompatible matrix is selected from the group consisting of calcium alginate, agarose, fibrin, an collagen.
Claim 5
Dependent Claim
16 words
The method of claim 1 , wherein said adipose tissue derived stromal cell is genetically modified.
Claim 6
Dependent Claim
12 words
The method of claim 1 , wherein said mammal is a human.
Claim 7
Dependent Claim
30 words
The method of claim 1 , wherein following administration of said chondrocytic cell to a cartilage defect area in a mammal, the cell further differentiates in situ in said human.
References Cited (Backward Citations)
FR2448901A1
Cited
US4362567A
Cited
US4377572A
Cited
FR2448900A1
Cited
US5863531A
Cited
US5160490A
Cited
US5902741A
Cited
US5486359A
Cited
US5197973A
Cited
US5723331A
Cited
WO1995033821A1
Cited
US5908784A
Cited
US6200606B1
Cited
US5786207A
Cited
WO1999028444A1
Cited
US6153432A
Cited
WO2000053795A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2008-01-11 | 2008-07-12 | 2009-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2012-01-11 | 2012-07-12 | 2013-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2016-01-11 | 2016-07-12 | 2017-01-11 | $7700.00 | Window Closed / Lapsed |