US6507747B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for concomitant structural and biochemical characterization of tissue
Assignee: Biotex Inc
•
Filing: 1999-11-26
•
Granted: 2003-01-14
•
Expires: 2019-11-26
Abstract
Abstract An optical imaging probe for providing information representative of morphological arid biochemical properties of a sample is provided. The optical imaging probe includes a spectroscopic imaging probe element and an OCT imaging probe element.
Inventors
- 👤 Ashok Gowda
- 👤 Roger McNichols
- 👤 Massoud Motamedi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:50
CPC Classifications
B; B82; B82Y; B82Y15/00; A; A61; A61B; A61B5/00; A61B5/0059; A61B5/0062; A61B5/0066
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
106 words
An optical imaging probe to provide information representative of morphological and biochemical properties of a sample, the optical imaging probe comprising: a spectroscopic imaging probe element, an OCT imaging probe element; an optical probe window; and a reflective optical filter disposed within an optical path between the optical window and the spectroscopic and OCT imaging probe elements and positioned to receive radiation incident on the optical probe window and to provide radiation of a first wavelength to the spectroscopic imaging probe element and to provide radiation of a second wavelength to the OCT imaging probe element, wherein the first wavelength is different than the second wavelength.
Claim 2
Dependent Claim
106 words
An optical imaging probe to provide information representative of morphological and biochemical properties of a sample, the optical imaging probe comprising: a spectroscopic imaging probe element, an OCT imaging probe element; an optical probe window; and a reflective optical filter disposed within an optical path between the optical window and the spectroscopic and OCT imaging probe elements and positioned to receive radiation incident on the optical probe window and to provide radiation of a first wavelength to the spectroscopic imaging probe element and to provide radiation of a second wavelength to the OCT imaging probe element, wherein the first wavelength is different than the second wavelength.
Claim 3
Dependent Claim
27 words
The optical imaging probe of claim 1 herein the optical imaging probe allows sequential imaging using the spectroscopic imaging probe element and the OCT imaging probe element.
Claim 4
Dependent Claim
27 words
The optical imaging probe of claim 1 wherein the optical imaging probe allows concomitant imaging using the spectroscopic imaging probe element and the OCT imaging probe element.
Claim 5
Dependent Claim
56 words
The optical imaging probe of claim 1 wherein the spectroscopic imaging probe element is used in a system selected from the group consisting of a fluorescence imaging system, an autofluorescence imaging system, a NIR absorption spectroscopic system, a NIR reflectance spectroscopic system, a Raman spectroscopic imaging system, a magnetic resonance imaging system, and an infrared system.
Claim 6
Dependent Claim
19 words
The optical imaging probe of claim 1 wherein the spectroscopic imaging probe element is a forward imaging type endoscope.
Claim 7
Dependent Claim
17 words
The optical imaging probe of claim 1 wherein the first wavelength is less than about 700 nm.
Claim 8
Dependent Claim
17 words
The optical imaging probe of claim 1 wherein the second wavelength is greater than about 700 nm.
Claim 9
Dependent Claim
17 words
The optical imaging probe of claim 1 wherein the first wavelength is in the NIR wavelength range.
Claim 10
Dependent Claim
16 words
The optical imaging probe of claim 1 wherein the reflective optical filter comprises a moveable mirror.
Claim 11
Dependent Claim
39 words
The optical imaging probe of claim 1 wherein the reflective optical filter provides a substantial amount of radiation of the first wavelength to the spectroscopic imaging probe element and wherein the first wavelength is less than about 700 nm.
Claim 12
Dependent Claim
39 words
The optical imaging probe of claim 1 wherein the reflective optical filter provides a substantial amount of radiation of the second wavelength to the OCT imaging probe element and wherein the second wavelength is greater than about 700 nm.
Claim 13
Dependent Claim
25 words
The optical imaging probe of claim 1 wherein the reflective optical filter reflect radiation of the first wavelength and transmits radiation of the second wavelength.
Claim 14
Dependent Claim
71 words
An optical imaging probe to provide information representative of morphological and biochemical properties of a sample, the optical imaging probe comprising: a spectroscopic imaging probe element; an optical probe window; and a means for receiving radiation incident on the optical probe window and for selectively providing radiation of a first wavelength to the spectroscopic imaging probe element and selectively providing radiation of a second wavelength to an OCT imaging probe element.
Claim 15
Dependent Claim
71 words
An optical imaging probe to provide information representative of morphological and biochemical properties of a sample, the optical imaging probe comprising: a spectroscopic imaging probe element; an optical probe window; and a means for receiving radiation incident on the optical probe window and for selectively providing radiation of a first wavelength to the spectroscopic imaging probe element and selectively providing radiation of a second wavelength to an OCT imaging probe element.
Claim 16
Dependent Claim
34 words
The optical imaging probe of claim 13 further comprising an OCT imaging probe element wherein the optical imaging probe allows sequential imaging using the spectroscopic imaging probe element and the OCT imaging probe element.
Claim 17
Dependent Claim
34 words
The optical imaging probe of claim 13 further comprising an OCT imaging probe element wherein the optical imaging probe allows concomitant imaging using the spectroscopic imaging probe element and the OCT imaging probe element.
Claim 18
Dependent Claim
27 words
The optical imaging probe of claim 13 wherein the first wavelength is less than about 700 nm and the second wavelength is greater than about 700 nm.
Claim 19
Dependent Claim
17 words
The optical imaging probe of claim 13 wherein the first wavelength is in the NIR wavelength range.
Claim 20
Dependent Claim
51 words
The optical imaging probe of claim 13 wherein the means for selectively providing radiation of a first wavelength to the spectroscopic imaging probe element provides a substantial amount of radiation of the first wavelength to the spectroscopic imaging probe element and wherein the first wavelength is less than about 700 nm.
Claim 21
Dependent Claim
51 words
The optical imaging probe of claim 13 wherein the means for selectively providing radiation of a second wavelength to the OCT imaging probe element provides a substantial amount of radiation of the second wavelength to the OCT imaging probe element and wherein the second wavelength is greater than about 700 nm.
Claim 22
Independent Claim
110 words
A method for non-invasively sensing biochemical and morphological characteristics of a target tissue comprising: providing optical radiation to the target tissue; receiving optical radiation from the target tissue, wherein the optical radiation received from the target tissue contains information about the biochemical and morphological characteristics of the target tissue; selectively providing a first portion of the received optical radiation to a first optical imaging system, wherein the first portion of the received optical radiation comprises a first wavelength range; and selectively providing a second portion of the received optical radiation to a second optical imaging system, wherein the second portion of the received optical radiation comprises a second wavelength range.
Claim 23
Independent Claim
110 words
A method for non-invasively sensing biochemical and morphological characteristics of a target tissue comprising: providing optical radiation to the target tissue; receiving optical radiation from the target tissue, wherein the optical radiation received from the target tissue contains information about the biochemical and morphological characteristics of the target tissue; selectively providing a first portion of the received optical radiation to a first optical imaging system, wherein the first portion of the received optical radiation comprises a first wavelength range; and selectively providing a second portion of the received optical radiation to a second optical imaging system, wherein the second portion of the received optical radiation comprises a second wavelength range.
Claim 24
Dependent Claim
16 words
The method of claim 20 wherein the first optical imaging system is a spectroscopic imaging system.
Claim 25
Dependent Claim
53 words
The method of claim 21 wherein the spectroscopic imaging system is used in a system selected from the group consisting of a fluorescence imaging system, an autofluorescence imaging system, a NIR absorption spectroscopic system, a NIR reflectance spectroscopic system, a Raman spectroscopic imaging system, a magnetic resonance imaging system, and an infrared system.
Claim 26
Dependent Claim
19 words
The method of claim 20 wherein the first wavelength range comprises radiation having wavelengths in the NIR wavelength range.
Claim 27
Dependent Claim
16 words
The method of claim 20 wherein the second optical imaging system is an OCT imaging system.
Claim 28
Dependent Claim
21 words
The method of claim 20 wherein the first wavelength range comprises radiation having wavelengths tat are less than about 700 nm.
Claim 29
Dependent Claim
21 words
The method of claim 20 wherein the second wavelength range comprises radiation having wavelengths which are greater than about 700 nm.
Claim 30
Dependent Claim
38 words
The method of claim 20 wherein selectively providing a first portion of the received optical radiation to a first optical imaging system is performed by a reflective optical filter disposed within a path of the received optical radiation.
Claim 31
Dependent Claim
46 words
The method of claim 27 wherein the reflective optical filter provides a substantial amount of radiation of the first wavelength range of the optical radiation received from the target tissue to a spectroscopic imaging system and wherein the first wavelength is less than about 700 nm.
Claim 32
Dependent Claim
60 words
The method of claim 27 wherein selectively providing a second portion of the received optical radiation to a second optical imaging system is performed by the reflective optical filter, and wherein the reflective optical filter provides a substantial amount of radiation of the second wavelength range of the optical radiation received from the target tissue to a OCT imaging system.
Claim 33
Dependent Claim
19 words
The method of claim 27 wherein the first wavelength range comprises radiation having wavelengths in the NIR wavelength range.
Claim 34
Dependent Claim
16 words
The method of claim 20 wherein the target tissue comprises a lesion, a tumor, or plaque.
Claim 35
Dependent Claim
22 words
The method of claim 20 wherein the target tissue is selected from the group consisting of skin, dental tissue, and cervical tissue.
Claim 36
Independent Claim
168 words
A method for non-invasively sensing biochemical and morphological characteristics of a target tissue, the method comprising: screening the target tissue using an optical imaging system having a spectroscopic imaging modality and an OCT imaging modality, the optical imaging system comprising: a spectroscopic imaging system; an OCT imaging system; a data analysis unit; and an OCT/spectroscopic imaging probe comprising: a spectroscopic imaging probe element; an OCT imaging probe element; an optical probe window; and a reflective optical filter disposed within an optical path between the optical probe window and the spectroscopic and OCT imaging probe elements and positioned to receive radiation incident on the optical probe window and to selectively provide radiation of a first wavelength to the spectroscopic imaging probe element and to selectively provide radiation of a second wavelength to the OCT imaging probe element; detecting specific regions of interest in the target tissue using the spectroscopic imaging modality; and obtaining information about the morphological characteristics of those specific regions of interest using the OCT imaging modality.
Claim 37
Independent Claim
168 words
A method for non-invasively sensing biochemical and morphological characteristics of a target tissue, the method comprising: screening the target tissue using an optical imaging system having a spectroscopic imaging modality and an OCT imaging modality, the optical imaging system comprising: a spectroscopic imaging system; an OCT imaging system; a data analysis unit; and an OCT/spectroscopic imaging probe comprising: a spectroscopic imaging probe element; an OCT imaging probe element; an optical probe window; and a reflective optical filter disposed within an optical path between the optical probe window and the spectroscopic and OCT imaging probe elements and positioned to receive radiation incident on the optical probe window and to selectively provide radiation of a first wavelength to the spectroscopic imaging probe element and to selectively provide radiation of a second wavelength to the OCT imaging probe element; detecting specific regions of interest in the target tissue using the spectroscopic imaging modality; and obtaining information about the morphological characteristics of those specific regions of interest using the OCT imaging modality.
Claim 38
Dependent Claim
15 words
The method of claim 33 wherein the first wavelength is in the NOR wavelength range.
Claim 39
Dependent Claim
15 words
The method of claim 33 wherein the first wavelength is less than about 700 nm.
Claim 40
Dependent Claim
15 words
The method of claim 33 wherein the second wavelength is greater than about 700 nm.
Claim 41
Dependent Claim
16 words
The method of claim 33 wherein the target tissue comprises a lesion, a tumor, or plaque.
Claim 42
Dependent Claim
22 words
The method of claim 33 wherein the target tissue is selected from the group consisting of skin, dental tissue, and cervical tissue.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-01-13 | 2006-07-15 | 2007-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-01-13 | 2010-07-15 | 2011-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-01-13 | 2014-07-15 | 2015-01-14 | $7700.00 | Window Closed / Lapsed |