US6506408B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable or insertable therapeutic agent delivery device
Assignee: Boston Scientific Scimed Inc
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Filing: 2000-07-13
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Granted: 2003-01-14
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Expires: 2020-07-13
Abstract
Abstract Disclosed herein is an implantable or insertable therapeutic agent delivery device comprising a coating material provided on at least a portion of said device, said coating material prohibiting substantial release therefrom of a therapeutic agent at or below about a physiological pH and allowing substantial release therefrom of a therapeutic agent at or above about said physiological pH. Also disclosed herein are coating materials for the implantable or insertable therapeutic agent delivery device. The coating materials are preferably polymers derivatized to contain moieties that are cationically charged at a pH below their pKa values and which thus can attract negatively charged therapeutically agents at pH values below their pKa values and which become predominantly uncharged at pH values above about their pKa values and thus substantially release the negatively charged therapeutic agents at such pH values, which are preferably about physiological pH. Also disclosed are methods of derivatizing a polymer to contain such moieties and methods of providing a coating of the derivatized polymer onto at least a portion of a surface of an implantable or insertable therapeutic agent delivery device.
Inventors
- 👤 Maria Palasis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/145; A61L29/00; A61L29/14; A61L29/145; A61L29/16; A61L31/16; A61P; A61P9/00; A61P9/10; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L2300/00; A61L2300/60; A61L2300/602; A61L2300/606
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
83 words
An implantable or insertable therapeutic agent delivery device comprising a coating material provided on at least a portion of said device, said coating material prohibiting substantial release therefrom of a therapeutic agent at or below about a physiological pH and allowing substantial release therefrom of a therapeutic agent at or above about said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
Claim 2
Dependent Claim
83 words
An implantable or insertable therapeutic agent delivery device comprising a coating material provided on at least a portion of said device, said coating material prohibiting substantial release therefrom of a therapeutic agent at or below about a physiological pH and allowing substantial release therefrom of a therapeutic agent at or above about said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
Claim 3
Dependent Claim
14 words
The device of claim 1 wherein said coating material further comprises said therapeutic agent.
Claim 4
Dependent Claim
33 words
The device of claim 2 wherein said moieties carry a positive charge at a pH at or below about said physiological pH and are substantially uncharged at or above about said physiological pH.
Claim 5
Dependent Claim
19 words
The device of claim 1 wherein said physiological pH is in the range from about 7.2 to about 7.6.
Claim 6
Dependent Claim
16 words
The device of claim 4 wherein said physiological pH is about the pH of mammalian blood.
Claim 7
Dependent Claim
11 words
The device of claim 5 wherein said pH is about 7.4.
Claim 8
Dependent Claim
13 words
The device of claim 1 wherein said biocompatible polymer comprises a hydrogel polymer.
Claim 9
Dependent Claim
14 words
The device of claim 7 wherein said hydrogel polymer comprises a poly(acrylic acid) polymer.
Claim 10
Dependent Claim
26 words
The device of claim 8 wherein said moieties are provided by at least one compound selected from the group consisting of aminoethyl pyridine and aminopropyl imidazole.
Claim 11
Dependent Claim
12 words
The device of claim 1 which is a stent or balloon catheter.
Claim 12
Dependent Claim
22 words
A method of delivering a therapeutic agent to a mammal comprising implanting or inserting the device of claim 1 into a mammal.
Claim 13
Dependent Claim
32 words
The device of claim 1 wherein said negatively charged therapeutic agent is selected from the group consisting of DNA, RNA, polynucleotides, oligopeptides, viruses, drugs and nonviral vectors comprising a therapeutic nucleic acid.
Claim 14
Independent Claim
83 words
A method of coating at least a portion of an implantable or insertable medical device comprising contacting said medical device with a coating material that prohibits substantial release therefrom of a therapeutic agent at or below about a physiological pH and allows substantial release therefrom of a therapeutic agent at or above said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
Claim 15
Independent Claim
83 words
A method of coating at least a portion of an implantable or insertable medical device comprising contacting said medical device with a coating material that prohibits substantial release therefrom of a therapeutic agent at or below about a physiological pH and allows substantial release therefrom of a therapeutic agent at or above said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
Claim 16
Dependent Claim
41 words
The method of claim 13 wherein said medical device is contacted with said coating material by a method selected from the group consisting of dipping said device into or spraying onto said device a solution or suspension of said coating material.
Claim 17
Independent Claim
143 words
A method of coating at least a portion of an implantable or insertable medical device comprising contacting said medical device with a polymer and subsequently reacting, in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, carboxyl groups in said polymer with a compound containing a moiety that carries a positive charge at or below about a physiological pH and that is substantially uncharged at or above said physiological pH, thereby forming a coating on at least a portion of the implantable or insertable medical device which prohibits substantial release therefrom of a therapeutic agent at or below about a physiological pH and which allows substantial release therefrom of a therapeutic agent at or above about said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
Claim 18
Independent Claim
143 words
A method of coating at least a portion of an implantable or insertable medical device comprising contacting said medical device with a polymer and subsequently reacting, in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, carboxyl groups in said polymer with a compound containing a moiety that carries a positive charge at or below about a physiological pH and that is substantially uncharged at or above said physiological pH, thereby forming a coating on at least a portion of the implantable or insertable medical device which prohibits substantial release therefrom of a therapeutic agent at or below about a physiological pH and which allows substantial release therefrom of a therapeutic agent at or above about said physiological pH, wherein said therapeutic agent is negatively charged and said coating material comprises a biocompatible polymer comprising basic moieties that have a pKa value of less than about 7.4.
References Cited (Backward Citations)
US5091205A
Cited
US5304121A
Cited
GB2269178A
Cited
US5554147A
Cited
WO1996039949A1
Cited
EP0963761A1
Cited
US5952232A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-01-13 | 2006-07-15 | 2007-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-01-13 | 2010-07-15 | 2011-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-01-13 | 2014-07-15 | 2015-01-14 | $7700.00 | Window Closed / Lapsed |