US6498195B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl) as an anticarcinogenic agent
Assignee: Rutgers, The State University of New Jersey
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Filing: 2001-06-13
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Granted: 2002-12-24
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Expires: 2021-06-13
Abstract
Abstract Compositions and methods are provided for prevention and treatment of cancer. The compositions comprise pure hydroxylated chalcone compounds of licorice root ( Glycyrrhiza glabra ) including 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Inventors
- 👤 Robert T. Rosen
- 👤 Chi-Tang Ho
- 👤 Robert S. DiPaola
- 👤 Mohamed M. Rafi
- 👤 Bret C. Vastano
- 👤 Geetha Ghai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:35
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/12; A61P; A61P35/00; A61P43/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
21 words
A method of inducing phosphorylation of bcl-2 in cells or tissues comprising contacting cells or tissues with a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Claim 2
Independent Claim
21 words
A method of inducing phosphorylation of bcl-2 in cells or tissues comprising contacting cells or tissues with a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Claim 3
Dependent Claim
21 words
A method of inducing apoptosis in cells or tissues comprising contacting cells or tissues with the composition of claim 1 .
Claim 4
Independent Claim
17 words
A method of inhibiting growth of tumor cells comprising contacting tumor cells with a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Claim 5
Independent Claim
17 words
A method of inhibiting growth of tumor cells comprising contacting tumor cells with a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Claim 6
Independent Claim
23 words
A method of preventing or treating cancer or tumor cell growth in an animal comprising administering to the animal a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
Claim 7
Independent Claim
23 words
A method of preventing or treating cancer or tumor cell growth in an animal comprising administering to the animal a composition comprising 1-propanone-1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4′-hydroxyphenyl).
References Cited (Backward Citations)
JPH02204495A
Cited
EP0998939A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-12-23 | 2006-06-24 | 2006-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-12-23 | 2010-06-24 | 2010-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-12-23 | 2014-06-24 | 2014-12-24 | $7700.00 | Window Closed / Lapsed |