US6468287B1
Expired / Lapsed
US
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Lancet for capillary puncture blood samples
Assignee: Medtronic Inc
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Filing: 1997-04-30
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Granted: 2002-10-22
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Expires: 2017-04-30
Abstract
Abstract A piercing instrument ( 12 ) for obtaining a non-activated drop of blood (B) by capillary puncture is formed by depositing a coating agent ( 20 ) on the exterior surface of the piercing instrument ( 12 ). The coating agent comprises compounds that inhibit the activation of blood.
Inventors
- 👤 Robert F. Baugh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 04:46
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/15; A61B5/151; A61B5/15142; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/150374; A61B5/150381; A61B5/150412; A61B5/150427; A61B5/150503; A61B5/150511; A61B5/150755; A61B5/15101; A61B5/15103; A61B5/15105
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
82 words
A lancet for obtaining a drop of blood for analysis by capillary puncture comprising a needle having an exterior surface that is adapted to puncture skin and a removable coating on said exterior surface wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said needle is transferred from said needle to said puncture site, said coating comprising a composition which inhibits contact activation of the drop of blood at said puncture site.
Claim 2
Dependent Claim
82 words
A lancet for obtaining a drop of blood for analysis by capillary puncture comprising a needle having an exterior surface that is adapted to puncture skin and a removable coating on said exterior surface wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said needle is transferred from said needle to said puncture site, said coating comprising a composition which inhibits contact activation of the drop of blood at said puncture site.
Claim 3
Dependent Claim
21 words
A lancet as defined in claim 1 , wherein said coating further comprises a material that is capable of inhibiting fibrinolysis.
Claim 4
Dependent Claim
27 words
A lancet as defined in claim 1 , wherein said coating further includes a material that is capable of inhibiting platelet activation of said drop of blood.
Claim 5
Independent Claim
69 words
An apparatus for obtaining blood samples by capillary puncture comprising a lancet and a removable coating on the surface of said lancet wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said lancet is transferred from said lancet to said puncture site, said coating including a blood platelet inhibitor, a serine protease inhibitor, and a monoclonal antibody to thromboplastin.
Claim 6
Independent Claim
69 words
An apparatus for obtaining blood samples by capillary puncture comprising a lancet and a removable coating on the surface of said lancet wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said lancet is transferred from said lancet to said puncture site, said coating including a blood platelet inhibitor, a serine protease inhibitor, and a monoclonal antibody to thromboplastin.
Claim 7
Dependent Claim
15 words
An apparatus as defined in claim 4 , wherein said serine protease inhibitor is aprotinin.
Claim 8
Dependent Claim
18 words
An apparatus as defined in claim 4 , wherein said composition further comprises a bacteriostatic or bactericidal agent.
Claim 9
Dependent Claim
16 words
An apparatus as defined in claim 4 , wherein said composition further comprises an analgesic compound.
Claim 10
Independent Claim
77 words
An apparatus for inhibiting contact activation of blood, comprising an instrument adapted to puncture a bodily tissue and having an exterior surface coated with a removable composition, wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said instrument is transferred from said instrument to said puncture site, said composition comprising one or more compounds that specifically inhibit one or more blood activation mechanisms at the puncture site.
Claim 11
Independent Claim
77 words
An apparatus for inhibiting contact activation of blood, comprising an instrument adapted to puncture a bodily tissue and having an exterior surface coated with a removable composition, wherein the portion of said coating that comes in contact with a puncture site obtained by capillary puncture with said instrument is transferred from said instrument to said puncture site, said composition comprising one or more compounds that specifically inhibit one or more blood activation mechanisms at the puncture site.
Claim 12
Dependent Claim
21 words
The apparatus of claim 8 , wherein one or more of said compounds specifically inhibits one or more blood activation mechanism.
Claim 13
Dependent Claim
23 words
The apparatus of claim 9 , wherein said composition comprises a blood platelet inhibitor, a serine protease inhibitor, and an antibody to thromboplastin.
Claim 14
Dependent Claim
13 words
The apparatus of claim 10 , wherein said composition further comprises an analgesic.
Claim 15
Dependent Claim
16 words
The apparatus of claim 10 , wherein said composition further comprises a bacteriostatic or bactericidal agent.
Claim 16
Dependent Claim
21 words
The apparatus of claim 8 , wherein said composition comprises a compound that inhibits contact activation of the intrinsic coagulation system.
Claim 17
Dependent Claim
19 words
The apparatus of claim 8 , wherein said composition comprises a compound that inhibits fibrinolysis activation by contact activation.
Claim 18
Dependent Claim
19 words
The apparatus of claim 8 , wherein said composition comprises a compound that inhibits platelet activation by connective tissue.
Claim 19
Dependent Claim
20 words
The apparatus of claim 8 , wherein said composition comprises a compound that inhibits tissue factor activation of extrinsic coagulation.
Claim 20
Independent Claim
75 words
A method of obtaining a drop of blood for analysis, comprising the steps of: coating an outside surface of a lancet with a removable composition that inhibits contact activation of the drop of blood; and puncturing a bodily tissue with said outside surface of said lancet to obtain the drop of blood, wherein the portion of said composition that comes in contact with said bodily tissue is transferred from said lancet to said puncture site.
Claim 21
Independent Claim
75 words
A method of obtaining a drop of blood for analysis, comprising the steps of: coating an outside surface of a lancet with a removable composition that inhibits contact activation of the drop of blood; and puncturing a bodily tissue with said outside surface of said lancet to obtain the drop of blood, wherein the portion of said composition that comes in contact with said bodily tissue is transferred from said lancet to said puncture site.
Claim 22
Dependent Claim
19 words
The method of claim 17 , wherein said composition includes a compound that inhibits fibrinolysis activation by contact activation.
Claim 23
Dependent Claim
14 words
The method of claim 18 , wherein said composition includes a serine protease inhibitor.
Claim 24
Dependent Claim
19 words
The method of claim 17 , wherein said composition includes a compound that inhibits platelet activation by connective tissue.
Claim 25
Dependent Claim
13 words
The method of claim 20 , wherein said compound is a prostacylin analog.
Claim 26
Dependent Claim
20 words
The method of claim 17 , wherein said composition includes a compound that inhibits tissue factor activation of extrinsic coagulation.
Claim 27
Dependent Claim
21 words
The method of claim 17 , wherein said composition inclides a compound that inhibits contact activation of the intrinsic coagulation system.
Claim 28
Dependent Claim
25 words
The method of claim 17 , wherein said composition prevents contact activation of the drop of blood at the site of the punctures bodily tissue.
Claim 29
Independent Claim
85 words
A method for obtaining a non-activated drop of blood comprising: coating a surface of an instrument with a removable composition comprising a serine protease inhibitor, a blood platelet inhibitor, and a monoclonal antibody to thromboplastin; and puncturing a bodily tissue with said instrument, thereby transferring the portion of said composition that comes in contact with the puncture site from said instrument to the puncture site wherein said serine protease inhibitor, said blood platelet inhibitor, and said monoclonal antibody inhibit one or more blood activation mechanisms.
Claim 30
Independent Claim
85 words
A method for obtaining a non-activated drop of blood comprising: coating a surface of an instrument with a removable composition comprising a serine protease inhibitor, a blood platelet inhibitor, and a monoclonal antibody to thromboplastin; and puncturing a bodily tissue with said instrument, thereby transferring the portion of said composition that comes in contact with the puncture site from said instrument to the puncture site wherein said serine protease inhibitor, said blood platelet inhibitor, and said monoclonal antibody inhibit one or more blood activation mechanisms.
Claim 31
Dependent Claim
67 words
An improved lancet for obtaining a drop of blood for analysis by capillary puncture of a bodily tissue, wherein the improvement comprises said lancet having a removable coating thereon of a composition which precludes contact activation, platelet activation, and fibrinolysis of the blood sample, wherein the portion of said coating that comes in contact with a bodily tissue is transferred from said lancet to the puncture site.
Claim 32
Dependent Claim
67 words
An improved lancet for obtaining a drop of blood for analysis by capillary puncture of a bodily tissue, wherein the improvement comprises said lancet having a removable coating thereon of a composition which precludes contact activation, platelet activation, and fibrinolysis of the blood sample, wherein the portion of said coating that comes in contact with a bodily tissue is transferred from said lancet to the puncture site.
Claim 33
Dependent Claim
20 words
An improved lancet as defined in claim 26 , wherein said composition includes a serine protease inhibitor or analogues thereof.
Claim 34
Dependent Claim
16 words
An improved lancet as defined in claim 27 , wherein said serine protease inhibitor is aprotinin.
Claim 35
Dependent Claim
16 words
An improved lancet as defined in claim 26 , wherein said composition includes an antiplatelet compound.
Claim 36
Dependent Claim
15 words
An improved lancet as defined in claim 29 , wherein said antiplatelet compound is prostacyclin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-10-21 | 2006-04-22 | 2006-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-10-21 | 2010-04-22 | 2010-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-10-21 | 2014-04-22 | 2014-10-22 | $7700.00 | Window Closed / Lapsed |