US6402781B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Percutaneous mitral annuloplasty and cardiac reinforcement
Assignee: Edwards Lifesciences AG
•
Filing: 2000-01-31
•
Granted: 2002-06-11
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Expires: 2020-01-31
Abstract
Abstract A mitral annuloplasty and LV restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins. The device places tension on adjacent structures, reducing the diameter and/or limiting expansion of the mitral annulus and/or limiting diastolic expansion of the left ventricle. These effects may be beneficial for patients with dilated cardiomyopathy.
Inventors
- 👤 Jonathan J. Langberg
- 👤 Michael D. Lesh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:15
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2442; A61F2/2451; A61F2/2466; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056; A61N2001/0585
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
122 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration; and a lock for retaining the elongate body in the second configuration at least in part within the coronary sinus.
Claim 2
Dependent Claim
122 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration; and a lock for retaining the elongate body in the second configuration at least in part within the coronary sinus.
Claim 3
Dependent Claim
51 words
The medical apparatus according to claim 1 , wherein the forming element is secured to the elongate body at a point of attachment and the forming element is movable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations.
Claim 4
Dependent Claim
35 words
The medical apparatus according to claim 2 , wherein the forming element is adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration.
Claim 5
Dependent Claim
35 words
The medical apparatus according to claim 3 , further comprising a cutting tool which is adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus.
Claim 6
Dependent Claim
20 words
A medical apparatus as in claim 1 , wherein the elongate body defines an arc when in the remodeling configuration.
Claim 7
Dependent Claim
34 words
A medical apparatus as in claim 5 , wherein a best fit constant radius curve corresponding to the arc has a radius within the range of from about 10 mm to about 20 mm.
Claim 8
Dependent Claim
15 words
A medical apparatus as in claim 1 , wherein the lock comprises a locking ring.
Claim 9
Dependent Claim
15 words
A medical apparatus as in claim 1 , wherein the lock comprises an interference fit.
Claim 10
Dependent Claim
15 words
A medical apparatus as in claim 1 , wherein the lock comprises an adhesive bond.
Claim 11
Dependent Claim
15 words
A medical apparatus as in claim 1 , wherein the lock comprises a suture knot.
Claim 12
Dependent Claim
14 words
A medical apparatus as in claim 1 , wherein the lock comprises a clamp.
Claim 13
Dependent Claim
15 words
A medical apparatus as in claim 1 , wherein the lock comprises a compression fit.
Claim 14
Dependent Claim
14 words
A medical apparatus as in claim 1 , wherein the lock comprises a ratchet.
Claim 15
Dependent Claim
28 words
A medical apparatus as in claim 1 , wherein the lock comprises an engagement surface, which is movable between a first, disengaged configuration and a second, engaged configuration.
Claim 16
Dependent Claim
17 words
A medical apparatus as in claim 1 , wherein the lock is biased in a locked direction.
Claim 17
Dependent Claim
17 words
A medical apparatus as in claim 1 , wherein the lock is biased in an unlocked direction.
Claim 18
Dependent Claim
15 words
A medical apparatus as in claim 1 , further comprising a coating on the body.
Claim 19
Dependent Claim
30 words
A medical apparatus as in claim 1 , wherein the apparatus is movable from the implantation configuration to the remodeling configuration in response to proximal retraction of the forming element.
Claim 20
Dependent Claim
30 words
A medical apparatus as in claim 1 , wherein the apparatus is movable from the implantation configuration to the remodeling configuration in response to distal advancement of the forming element.
Claim 21
Dependent Claim
23 words
A medical apparatus as in claim 1 , further comprising an anchor for retaining the apparatus at a deployment site within a vessel.
Claim 22
Dependent Claim
18 words
A medical apparatus as in claim 20 , wherein the anchor comprises a distal extension of the apparatus.
Claim 23
Dependent Claim
24 words
A medical apparatus as in claim 20 , wherein the anchor comprises a friction enhancing surface structure for engaging the wall of the vessel.
Claim 24
Dependent Claim
23 words
A medical apparatus as in claim 20 , wherein the anchor comprises at least one barb for piercing the wall of the vessel.
Claim 25
Dependent Claim
22 words
A medical apparatus as in claim 1 , wherein the apparatus has an axial length of no more than about 10 cm.
Claim 26
Dependent Claim
24 words
A medical apparatus as in claim 24 , wherein the maximum cross sectional dimension through the apparatus is no more than about 10 mm.
Claim 27
Dependent Claim
22 words
A medical apparatus as in claim 1 , further comprising an axially extending support in the body, attached to the forming element.
Claim 28
Dependent Claim
16 words
A medical apparatus as in claim 1 , wherein the forming element comprises a polymeric strand.
Claim 29
Dependent Claim
16 words
A medical apparatus as in claim 1 , wherein the forming element comprises a metal wire.
Claim 30
Dependent Claim
16 words
A medical apparatus as in claim 1 , wherein the forming element comprises a multifilament structure.
Claim 31
Dependent Claim
211 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and moveable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool which is adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body maintains a substantially constant length when manipulated by the forming element between the first and second configurations.
Claim 32
Dependent Claim
211 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and moveable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool which is adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body maintains a substantially constant length when manipulated by the forming element between the first and second configurations.
Claim 33
Dependent Claim
207 words
A medical apparatus for remodeling a mitral valve annulus adacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and movable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body is relatively non-compressible while the elongate body is adjusted between the first and second configurations.
Claim 34
Dependent Claim
207 words
A medical apparatus for remodeling a mitral valve annulus adacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and movable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body is relatively non-compressible while the elongate body is adjusted between the first and second configurations.
Claim 35
Dependent Claim
205 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and movable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body is interchangeably adjustable between the first and second configurations within the coronary sinus.
Claim 36
Dependent Claim
205 words
A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising: an elongate body, having a proximal end region and a distal end region, each of the proximal and distal end regions dimensioned to reside completely within the vascular system, the elongate body being movable from a first configuration for transluminal delivery to at least a portion of the coronary sinus and a second configuration for remodeling the mitral valve annulus proximate the coronary sinus; a forming element attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration, the forming element secured to the elongate body at a point of attachment and movable relative to the elongate body in order to adjust the elongate body within the coronary sinus between the first and second configurations, the forming element adapted to be severed while the elongate body is positioned at least in part within the coronary sinus in the second configuration; and a cutting tool adapted to sever the forming element while the elongate body is positioned at least in part within the coronary sinus; wherein the elongate body is interchangeably adjustable between the first and second configurations within the coronary sinus.
Claim 37
Independent Claim
146 words
A method of performing transluminal mitral annuloplasty, comprising the steps of: selecting a prosthesis having a proximal end and a distal end; providing a deployment system cooperating with the prosthesis and which is adapted to at least in part deliver the prosthesis into the coronary sinus; inserting the deployment system and prosthesis into the venous system; transluminally advancing the prosthesis into at least a portion of the coronary sinus; tightening the prosthesis to generate a compressive force on the adjacent cardiac musculature and influence the size of the mitral valve annulus, the tightening step achieved by proximally retracting a forming element while resisting proximal movement of the prosthesis; and locking the prosthesis after the step of tightening; wherein the prosthesis is interchangeably adjustable between tightening to generate the compressive force, and untightening to relieve the compressive force while the prosthesis is positioned within the coronary sinus.
Claim 38
Independent Claim
146 words
A method of performing transluminal mitral annuloplasty, comprising the steps of: selecting a prosthesis having a proximal end and a distal end; providing a deployment system cooperating with the prosthesis and which is adapted to at least in part deliver the prosthesis into the coronary sinus; inserting the deployment system and prosthesis into the venous system; transluminally advancing the prosthesis into at least a portion of the coronary sinus; tightening the prosthesis to generate a compressive force on the adjacent cardiac musculature and influence the size of the mitral valve annulus, the tightening step achieved by proximally retracting a forming element while resisting proximal movement of the prosthesis; and locking the prosthesis after the step of tightening; wherein the prosthesis is interchangeably adjustable between tightening to generate the compressive force, and untightening to relieve the compressive force while the prosthesis is positioned within the coronary sinus.
Claim 39
Dependent Claim
23 words
A method as in claim 33 , further comprising the step of percutaneously accessing the venous system prior to the transluminally advancing step.
Claim 40
Dependent Claim
24 words
A method as in claim 33 , wherein the accessing step is accomplished by accessing one of the internal jugular, subclavian and femoral veins.
Claim 41
Dependent Claim
19 words
A method as in claim 33 , further comprising the step of limiting diastolic expansion of the left ventricle.
Claim 42
Dependent Claim
17 words
A method as in claim 33 , wherein the transluminally advancing step is accomplished using a catheter.
Claim 43
Dependent Claim
24 words
A method as in claim 33 , wherein the locking step comprises moving an engagement surface from a disengaged configuration to an engaged configuration.
Claim 44
Dependent Claim
16 words
A method as in claim 33 , wherein the locking step comprises providing an interference fit.
Claim 45
Dependent Claim
16 words
A method as in claim 33 , wherein the locking step comprises providing an adhesive bond.
Claim 46
Dependent Claim
15 words
A method as in claim 33 , wherein the locking step comprises providing a knot.
Claim 47
Dependent Claim
16 words
A method as in claim 33 , wherein the locking step comprises providing a compression fit.
Claim 48
Dependent Claim
29 words
A method as in claim 33 , further comprising the steps of first measuring the coronary sinus and then selecting an appropriately sized prosthesis prior to the inserting step.
Claim 49
Dependent Claim
19 words
A method as in claim 33 , further comprising the step of measuring hemodynamic function following the locking step.
Claim 50
Dependent Claim
25 words
A method as in claim 44 , further comprising the step of determining an ongoing drug therapy taking into account the post implantation hemodynarnic function.
Claim 51
Independent Claim
132 words
A method of performing trasluminaI mitral annuloplasty, comprising the step of: selecting a prosthesis having a proximal end and a distal end; providing a deployment system cooperating with the prosthesis and which is adapted to at least in part deliver the prosthesis into the coronary sinus; inserting the deployment system and prosthesis into the venous system; transluminally advancing the prosthesis into at least a portion of the coronary sinus; tightening the prosthesis to generate a compressive force on the adjacent cardiac musculature and influence the size of the mitral valve annulus, the tightening step achieved by proximally retracting a forming element while resisting proximal movement of the prosthesis; and locking the prosthesis after the step of tightening; wherein the prosthesis maintains a substantially constant length when tightened to generate the compressive force.
Claim 52
Independent Claim
132 words
A method of performing trasluminaI mitral annuloplasty, comprising the step of: selecting a prosthesis having a proximal end and a distal end; providing a deployment system cooperating with the prosthesis and which is adapted to at least in part deliver the prosthesis into the coronary sinus; inserting the deployment system and prosthesis into the venous system; transluminally advancing the prosthesis into at least a portion of the coronary sinus; tightening the prosthesis to generate a compressive force on the adjacent cardiac musculature and influence the size of the mitral valve annulus, the tightening step achieved by proximally retracting a forming element while resisting proximal movement of the prosthesis; and locking the prosthesis after the step of tightening; wherein the prosthesis maintains a substantially constant length when tightened to generate the compressive force.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-06-10 | 2005-12-10 | 2006-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-06-10 | 2009-12-10 | 2010-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-06-10 | 2013-12-10 | 2014-06-11 | $7700.00 | Window Closed / Lapsed |