US6326017B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for the localized delivery of agents to blood vessels
Assignee: WASHINGTON, University of
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Filing: 1993-04-05
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Granted: 2001-12-04
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Expires: 2013-04-05
Abstract
Abstract Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing, vascular disorders. Localized delivery of agents permits the use of agents, such as heparin, for which systemic distribution may be undesirable. Suitable agents include antithrombotic and anti-intimal proliferation agents. An agent may be delivered to a blood vessel by a carrier, such as a polymer, which is adapted to restrict the release of the agent into tissue adjacent to the blood vessel. Alternatively, after applying a carrier to a blood vessel, the carrier may be covered with a barrier adapted to restrict the release of the agent into tissue adjacent to the blood vessel. The methods of the present invention may be applied to a variety of surgical and nonsurgical clinical settings.
Inventors
- 👤 Marc R. Mayberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K31/551; A61K31/554; A61K31/60; A61K31/612; A61K31/616; A61K31/70; A61K31/715; A61K31/726; A61K31/727; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
101 words
A method for the treatment of vascular disorders, comprising: exposing an external surface of an artery or vein; applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly to said external surface; and covering said polymer matrix with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein, so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 2
Independent Claim
101 words
A method for the treatment of vascular disorders, comprising: exposing an external surface of an artery or vein; applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly to said external surface; and covering said polymer matrix with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein, so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 3
Independent Claim
98 words
A method for the treatment of vascular disorders, comprising applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly into contact with an external surface of an artery or vein, said polymer matrix covered with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 4
Independent Claim
98 words
A method for the treatment of vascular disorders, comprising applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly into contact with an external surface of an artery or vein, said polymer matrix covered with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 5
Independent Claim
99 words
A method for the treatment of vascular disorders, comprising: applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly into contact with an external surface of an artery or vein; and covering said polymer matrix with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein, so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 6
Independent Claim
99 words
A method for the treatment of vascular disorders, comprising: applying a polymer matrix, which is permeable to an agent for the treatment of a vascular disorder and is impregnated with said agent, directly into contact with an external surface of an artery or vein; and covering said polymer matrix with a barrier adapted to restrict the release of said agent into tissue adjacent to said artery or vein, so that said agent diffuses from said polymer directly to said external surface of said artery or vein, thereby producing a localized effect on said artery or vein without systemic effect.
Claim 7
Independent Claim
20 words
The method of any of claims 1 , 2 , and 3 wherein said artery or vein is an artery.
Claim 8
Dependent Claim
15 words
The method of claim 4 wherein said artery is a carotid, aorta or femoral artery.
Claim 9
Independent Claim
20 words
The method of any of claims 1 , 2 , and 3 wherein said artery or vein is a vein.
Claim 10
Independent Claim
33 words
The method of any of claims 1 , 2 , and 3 wherein said agent comprises at least one antithrombotic agent selected from the group consisting of aspirin, heparin and tissue plasminogen activator.
Claim 11
Independent Claim
31 words
The method of any of claims 1 , 2 and 3 wherein said agent comprises at least one anti-intimal proliferation agent selected from the group consisting of diltiazem, heparin and cilazapril.
Claim 12
Dependent Claim
34 words
The method of claim 1 or claim 3 wherein said step of covering comprises substantially surrounding the external surface, to which a polymer matrix has been applied, with a shell impermeable to said agent.
Claim 13
Dependent Claim
13 words
The method of claim 9 wherein said impermeable shell comprises a silicon polymer.
References Cited (Backward Citations)
US3797485A
Cited
US4808570A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-12-03 | 2005-06-04 | 2005-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-12-03 | 2009-06-04 | 2009-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-12-03 | 2013-06-04 | 2013-12-04 | $7700.00 | Window Closed / Lapsed |