US6312949B1
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Regulation of tyrosine hydroxylase expression
Assignee: Salk Institute for Biological Studies
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Filing: 1999-03-26
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Granted: 2001-11-06
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Expires: 2019-03-26
Abstract
Abstract The invention relates to methods and materials involved in the regulation of tyrosine hydroxylase expression as well as the treatment of catecholamine-related diseases. Specifically, the invention provides cells that contain exogenous nucleic acid having a nucleic acid sequence that encodes Nurr1 as well as methods and materials for inducing tyrosine hydroxylase expression, treating catecholamine-related deficiencies, and identifying tyrosine hydroxylase-related deficiencies.
Inventors
- 👤 Kazuhiro Sakurada
- 👤 Theo Palmer
- 👤 Fred H. Gage
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:58
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/71; C07K14/70567; A; A61; A61K; A61K48/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
51 words
A cell comprising exogenous nucleic acid, said exogenous nucleic acid comprising a nucleic acid sequence that encodes an amino acid sequence, wherein said nucleic acid sequence comprises the sequence set forth in SEQ ID NO: 1, wherein said amino acid sequence is expressed and induces tyrosine hydroxylase expression within said cell.
Claim 2
Dependent Claim
51 words
A cell comprising exogenous nucleic acid, said exogenous nucleic acid comprising a nucleic acid sequence that encodes an amino acid sequence, wherein said nucleic acid sequence comprises the sequence set forth in SEQ ID NO: 1, wherein said amino acid sequence is expressed and induces tyrosine hydroxylase expression within said cell.
Claim 3
Dependent Claim
13 words
The cell of claim 1 , wherein said cell is a mammalian cell.
Claim 4
Dependent Claim
15 words
The cell of claim 2 , wherein said cell is derived from an adult mammal.
Claim 5
Dependent Claim
14 words
The cell of claim 1 , wherein said cell is a neural progenitor cell.
Claim 6
Dependent Claim
15 words
The cell of claim 4 , wherein said cell is a midbrain neural progenitor cell.
Claim 7
Dependent Claim
13 words
The cell of claim 4 , wherein said cell is a neural cell.
Claim 8
Dependent Claim
24 words
The cell of claim 1 , wherein said cell expresses at least one polypeptide selected from the group consisting of Otx1, En1, and Ptx3.
Claim 9
Dependent Claim
17 words
The cell of claim 1 , wherein said tyrosine hydroxylase expression promotes DOPA production in said cell.
Claim 10
Dependent Claim
17 words
The cell of claim 1 , wherein said tyrosine hydroxylase expression promotes dopamine production in said cell.
Claim 11
Dependent Claim
19 words
The cell of claim 1 , wherein said tyrosine hydroxylase expression promotes norepinephrine and epinephrine production in said cell.
References Cited (Backward Citations)
WO1994004675A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-11-05 | 2005-05-07 | 2005-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-11-05 | 2009-05-07 | 2009-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-11-05 | 2013-05-07 | 2013-11-06 | $7700.00 | Window Closed / Lapsed |