US6230051B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for enhancing transdermal agent delivery or sampling
Assignee: Alza Corp
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Filing: 1997-06-17
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Granted: 2001-05-08
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Expires: 2017-06-17
Abstract
Abstract A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a relatively sharp angled leading edge which transitions to a relatively gradually angled blade edge.
Inventors
- 👤 Michel J. N. Cormier
- 👤 Avtar S. Nat
- 👤 Armand P. Neukermans
- 👤 Barry Block
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:50
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0015; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/15; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/150053; A61B5/150061; A61B5/150099; A61B5/150206; A61B5/150274; A61B5/150282; A61B5/150374; A61B5/150381; A61B5/150412; A61B5/150427; A61B5/150969; A61B5/150977; A61B5/150984; A61B5/151; A61B5/15101; A61B5/15103; A61B5/15105; A61B5/15107; A61B5/15113; A61B5/15142; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61B10/00; A61B10/0045; A61B17/00; A61B17/20; A61B17/205; A61M2037/0007; A61M2037/0023; A61M2037/0038; A61M2037/0046; A61M2037/0053
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
131 words
A device for treating the stratum corneum of a body surface comprising: a sheet having at least one opening therethrough and a plurality of microblades folded downward from the sheet, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, wherein the width of the microblade at the intersection of the microblade and the sheet is in the range of about 10 microns to about 500 microns and the thickness of the microblade is in the range of about 7 microns to about 100 microns.
Claim 2
Independent Claim
131 words
A device for treating the stratum corneum of a body surface comprising: a sheet having at least one opening therethrough and a plurality of microblades folded downward from the sheet, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, wherein the width of the microblade at the intersection of the microblade and the sheet is in the range of about 10 microns to about 500 microns and the thickness of the microblade is in the range of about 7 microns to about 100 microns.
Claim 3
Dependent Claim
36 words
The device of claim 1 , wherein the first angle is in the range of about 1° to 25° and the angle of the second angled segment is in the range of about 26° to 80°.
Claim 4
Dependent Claim
24 words
The device of claim 1 , wherein the first angle is about 15° and the angle of the second angled segment is about 30°.
Claim 5
Dependent Claim
24 words
The device of claim 1 , wherein the first angle is about 15° and the angle of the second angled segment is about 35°.
Claim 6
Dependent Claim
35 words
The device of claim 1 , further comprising a third angled segment contiguous with the second angled segment and having an angle relative to the axis greater than the angle of the second angled segment.
Claim 7
Dependent Claim
47 words
The device of claim 1 , further comprising a plurality of contiguous angled segments wherein each of the subsequent angled segments progressing proximally along the microblade from the second angled seqment have an angle relative to the axis greater than the angle of the preceding angled segment.
Claim 8
Dependent Claim
20 words
The device of claim 1 , wherein the first and second angled segments are part of an arc-shaped microblade tip.
Claim 9
Dependent Claim
32 words
The device of claim 1 , further comprising a therapeutic agent delivery device connected to the treating device and positioned to deliver a therapeutic agent through the opening to the body surface.
Claim 10
Dependent Claim
29 words
The device of claim 1 , further comprising a sampling device connected to the treating device and positioned to sample a substance from the body surface through the opening.
Claim 11
Dependent Claim
27 words
The device of claim 1 , wherein the microblades are configured to form pathways in the stratum corneum through which a substance can be introduced or withdrawn.
Claim 12
Dependent Claim
22 words
The device of claim 1 , wherein at least a portion of the microblade separates the second angled portion from the sheet.
Claim 13
Dependent Claim
17 words
The device of claim 1 wherein the length of the microblades is less than about 500 micrometers.
Claim 14
Independent Claim
148 words
A device for treating the stratum corneum of a body surface comprising: a sheet having at least one opening therethrough and a plurality of microblades located along a periphery thereof and extending downward from the sheet, at least a portion of the plurality of microblades having first angled segments located distally on each side of an axis along the length of the microblade, each of the first segments having a first angle relative to the axis, and contiguous with the first segments, second segments on each side of the axis each having an angle relative to the axis greater than the first angle, wherein the width of the microblade at the intersection of the microblade and the sheet is in the range of about 10 microns to about 500 microns and the thickness of the microblade is in the range of about 7 microns to about 100 microns.
Claim 15
Independent Claim
148 words
A device for treating the stratum corneum of a body surface comprising: a sheet having at least one opening therethrough and a plurality of microblades located along a periphery thereof and extending downward from the sheet, at least a portion of the plurality of microblades having first angled segments located distally on each side of an axis along the length of the microblade, each of the first segments having a first angle relative to the axis, and contiguous with the first segments, second segments on each side of the axis each having an angle relative to the axis greater than the first angle, wherein the width of the microblade at the intersection of the microblade and the sheet is in the range of about 10 microns to about 500 microns and the thickness of the microblade is in the range of about 7 microns to about 100 microns.
Claim 16
Dependent Claim
44 words
The device of claim 13 , wherein the first angle of each of the first segments is in the range of about 1° to 25° and the angle of each of the second angled segments is in the range of about 26° to 80°.
Claim 17
Dependent Claim
31 words
The device of claim 13 , wherein the first angle of each of the first segments is about 15° and the angle of each of the second segments is about 30°.
Claim 18
Dependent Claim
20 words
The device of claim 13 , wherein the first angle of each of the first segments are not equal angles.
Claim 19
Dependent Claim
19 words
The device of claim 13 , wherein the angle of each of the second segments are not equal angles.
Claim 20
Dependent Claim
32 words
The device of claim 13 , further comprising a therapeutic agent delivery device connected to the treating device and positioned to deliver a therapeutic agent through the opening to the body surface.
Claim 21
Dependent Claim
29 words
The device of claim 13 , further comprising a sampling device connected to the treating device and positioned to sample a substance from the body surface through the openings.
Claim 22
Dependent Claim
27 words
The device of claim 13 , wherein the microblades are configured to form pathways in the stratum corneum through which a substance can be introduced or withdrawn.
Claim 23
Dependent Claim
22 words
The device of claim 13 , wherein at least a portion of the microblade separates the second angled portion from the sheet.
Claim 24
Dependent Claim
18 words
The device of claim 10 , wherein the length of the microblades is less than about 500 micrometers.
Claim 25
Independent Claim
115 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first angle is about 15° and the angle of the second angled segment is about 30°.
Claim 26
Independent Claim
115 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first angle is about 15° and the angle of the second angled segment is about 30°.
Claim 27
Independent Claim
115 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first angle is about 15° and the angle of the second angled segment is about 35°.
Claim 28
Independent Claim
115 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first angle is about 15° and the angle of the second angled segment is about 35°.
Claim 29
Independent Claim
136 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle; and a plurality of contiguous angled segments wherein each of the subsequent angled segments progressing proximally along the microblade from the second angled segment have an angle relative to the axis greater than the angle of the preceding angled segment.
Claim 30
Independent Claim
136 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle; and a plurality of contiguous angled segments wherein each of the subsequent angled segments progressing proximally along the microblade from the second angled segment have an angle relative to the axis greater than the angle of the preceding angled segment.
Claim 31
Independent Claim
111 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first and second angled segments are part of an arc-shaped microblade tip.
Claim 32
Independent Claim
111 words
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be introduced or withdrawn, comprising: a sheet having at least one opening therethrough and a plurality of microblades extending downward therefrom, at least a portion of the plurality of microblades having a first angled segment located distally on the microblade with a first angle relative to an axis along the length of the microblade, and contiguous with the first angled segment, a second angled segment having an angle relative to the axis greater than the first angle, and wherein the first and second angled segments are part of an arc-shaped microblade tip.
Claim 33
Independent Claim
24 words
The device of claims 23 , 24 , 25 or 26 , wherein the length of the microblades is less than about 500 micrometers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-05-07 | 2004-11-06 | 2005-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-05-07 | 2008-11-06 | 2009-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-05-07 | 2012-11-06 | 2013-05-08 | $7700.00 | Window Closed / Lapsed |