US6205871B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular phantoms
Assignee: University of California
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Filing: 1998-12-22
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Granted: 2001-03-27
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Expires: 2018-12-22
Abstract
Abstract The invention provides materials and methods for modeling human blood vessels. Including panels of anatomically accurate vascular phantoms, such as carotid artery phantoms, comprising a range of stenotic conditions and other geometric variations; methods of making anatomically accurate vascular phantoms using stereolithography with an input data set representation of a natural vascular lumenal surface to construct an anatomically accurate vascular phantom comprising a physical representation of the surface; and methods of using the subject phantoms and panels of phantoms, such as methods of measuring a parameter of fluid flow through a panel of anatomically accurate vascular phantoms comprising a range of stenotic conditions.
Inventors
- 👤 David Saloner
- 👤 Joe Rapp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:34
CPC Classifications
G; G09; G09B; G09B23/00; G09B23/28; B; B33; B33Y; B33Y80/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
27 words
A panel of anatomically accurate vascular phantoms comprising a range of stenotic conditions varying from normal to critically stenosed (0% area reduction to greater than 99% reduction).
Claim 2
Dependent Claim
27 words
A panel of anatomically accurate vascular phantoms comprising a range of stenotic conditions varying from normal to critically stenosed (0% area reduction to greater than 99% reduction).
Claim 3
Dependent Claim
26 words
The panel of claim 1 wherein the phantoms are selected from carotid artery phantoms, renal artery segments, basilar tip aneurysm phantoms, and abdominal aortic aneurysm phantoms.
Claim 4
Dependent Claim
16 words
The panel of claim 1 wherein the panel provides a representative comprehensive scale of clinical stenosis.
Claim 5
Dependent Claim
21 words
The panel of claim 1 wherein the panel provides a representative comprehensive scale of clinical stenosis as measured by peak velocity.
Claim 6
Dependent Claim
55 words
A method of making a panel of anatomically accurate vascular phantoms according to claim 1 comprising the step of using stereolithography with an input data set representation of a natural vascular lumenal surface to construct an anatomically accurate vascular phantom comprising a physical representation of said surface, and repeating said step to make the panel.
Claim 7
Dependent Claim
20 words
The method of claim 5 , wherein the input data set representation is derived from high resolution magnetic resonance imaging.
Claim 8
Dependent Claim
17 words
The method of claim 5 , wherein the input data set representation is of excised atherosclerotic plaques.
Claim 9
Dependent Claim
26 words
The method of claim 5 , wherein the input data set representation is derived from high resolution magnetic resonance imaging of excised carotid artery atherosclerotic plaques.
Claim 10
Dependent Claim
42 words
A method of measuring a parameter of fluid flow through anatomically accurate vascular phantoms, comprising the step of flowing a fluid through a panel according to claim 1 and measuring a parameter of flow of the fluid through each of the phantoms.
Claim 11
Dependent Claim
31 words
The method of claim 9 , wherein the parameter is selected from peak systolic flow velocity, end diastolic flow velocity and a ratio of peak systolic and end diastolic flow velocities.
Claim 12
Dependent Claim
22 words
The method of claim 9 , wherein the measuring comprises Dopplar Ultrasound (DUS), magnetic resonance angiography (MRA) or cather-injected x-ray angiography (CA).
Claim 13
Dependent Claim
58 words
The method of claim 9 , wherein the panel comprises at least five different measures; the range of stenotic conditions is in approximately equal gradations providing a representative comprehensive scale of clinical stenosis; and each phantom of the panel is made of a silastic compatible with Dopplar Ultrasound (DUS), magnetic resonance angiography (MRA) and cather-injected x-ray angiography (CA).
Claim 14
Dependent Claim
32 words
The panel of claim 1 , wherein the phantoms model a vascular segment prone to pathogenic sclerosis selected from the group consisting of a carotid artery segment and a renal artery segment.
Claim 15
Dependent Claim
32 words
The panel of claim 1 , wherein the phantoms model a vascular segment prone to aneurymal distortion selected from the group consisting of a basilar tip aneurysm and an abdominal aortic aneurysm.
Claim 16
Dependent Claim
32 words
The panel of claim 1 , wherein the stenotic range is expressed as percent of relative occlusion, range of peak velocities, amount of eccentricity, degree of non-circularity, or degree of hemodynamic significance.
Claim 17
Dependent Claim
27 words
The panel of claim 1 , wherein the stenotic range is expressed as aneurysm size, or the ratio of the width of the neck to aneurysm diameter.
Claim 18
Dependent Claim
15 words
The panel of claim 1 , wherein the panel comprises at least five different measures.
Claim 19
Dependent Claim
25 words
The panel of claim 1 , wherein the range of stenotic conditions is in approximately equal gradations providing a representative comprehensive scale of clinical stenosis.
Claim 20
Dependent Claim
31 words
The panel of claim 1 , wherein each phantom of the panel is made of a silastic compatible with Dopplar Ultrasound (DUS), magnetic resonance angiography (MRA) and cather-injected x-ray angiography (CA).
Claim 21
Dependent Claim
58 words
The panel of claim 1 , wherein the panel comprises at least five different measures; the range of stenotic conditions is in approximately equal gradations providing a representative comprehensive scale of clinical stenosis; and each phantom of the panel is made of a silastic compatible with Dopplar Ultrasound (DUS), magnetic resonance angiography (MRA) and cather-injected x-ray angiography (CA).
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-03-26 | 2004-09-25 | 2005-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-03-26 | 2008-09-25 | 2009-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-03-26 | 2012-09-25 | 2013-03-27 | $7700.00 | Window Closed / Lapsed |