US6184038B1
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Transport proteins and their uses
Assignee: Marie Curie Cancer Care
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Filing: 1996-07-25
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Granted: 2001-02-06
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Expires: 2016-07-25
Abstract
Abstract The present invention relates to transport proteins, in particular VP22 and homologues thereof, and to methods of delivering these proteins and any associated molecules to a target population of cells. This transport protein has applications in gene therapy and methods of targeting agents to cells where targeting at high efficiency is required.
Inventors
- 👤 Peter Francis Joseph O'Hare
- 👤 Gillian Daphne Elliott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 07:55
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/87; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K48/00; C07K2319/00; C07K2319/01; C07K2319/10; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16622
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
51 words
A composition of formula A-B wherein A and B are covalently associated, wherein A comprises a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein, and B comprises a molecule that is desired to be delivered into a cell.
Claim 2
Dependent Claim
51 words
A composition of formula A-B wherein A and B are covalently associated, wherein A comprises a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein, and B comprises a molecule that is desired to be delivered into a cell.
Claim 3
Dependent Claim
19 words
A composition according to claim 1 wherein A comprises the amino acid sequence set forth in SEQ ID NO:1.
Claim 4
Dependent Claim
19 words
A composition according to claim 1 wherein A comprises the amino acid sequence set forth in SEQ ID NO:2.
Claim 5
Dependent Claim
11 words
A composition according to claim 1 wherein B is a peptide.
Claim 6
Dependent Claim
13 words
A composition according to claim 1 wherein B is a nucleic acid molecule.
Claim 7
Independent Claim
55 words
A method of delivering a desired molecule to a population of cells, the method comprising introducing into one or more cells in the population a composition comprising the desired molecule in association with a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein.
Claim 8
Independent Claim
55 words
A method of delivering a desired molecule to a population of cells, the method comprising introducing into one or more cells in the population a composition comprising the desired molecule in association with a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein.
Claim 9
Dependent Claim
16 words
The method of claim 6 where the desired molecule is covalently associated with the transport-active material.
Claim 10
Dependent Claim
44 words
The method of claim 6 where the desired molecule is covalently associated with an amino acid sequence selected from the group consisting of the amino acid sequence set forth in SEQ ID NO:1, and the amino acid sequence set forth in SEQ ID NO:2.
References Cited (Backward Citations)
EP0475623A1
Cited
WO1997004092A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-02-06 | 2004-08-07 | 2005-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-02-06 | 2008-08-07 | 2009-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-02-06 | 2012-08-07 | 2013-02-06 | $7700.00 | Window Closed / Lapsed |