US6183753B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Recombinant chimeric virus and uses thereof
Assignee: Intervet Inc
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Filing: 1997-02-21
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Granted: 2001-02-06
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Expires: 2017-02-21
Abstract
Abstract This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short viral genome region.
Inventors
- 👤 Mark D. Cochran
- 👤 Martha A. Wild
- 👤 Barbara J. Winslow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:12
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61P; A61P31/00; A61P31/12; A61P31/20; A61P31/22; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; A61K; A61K39/00; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16311; C12N2710/16341; C12N2710/16343; C12N2710/16361; C12N2710/16362; C12N2830/00; C12N2830/60; C12N2840/00; C12N2840/20; C12N2840/203
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
28 words
A recombinant herpesvirus of turkeys—Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short viral genome region.
Claim 2
Dependent Claim
28 words
A recombinant herpesvirus of turkeys—Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short viral genome region.
Claim 3
Dependent Claim
43 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 1 , wherein a foreign DNA sequence is inserted within a non-essential region of the herpesvirus of turkeys—Marek's disease virus chimera viral genome, and is capable of being expressed in a host cell.
Claim 4
Dependent Claim
39 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence is inserted within an EcoR1 #9 fragment of the unique long region of the herpesvirus of turkeys—Marek's disease virus chimera viral genome.
Claim 5
Dependent Claim
20 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence encodes a polypeptide.
Claim 6
Dependent Claim
20 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence encodes a cytokine.
Claim 7
Dependent Claim
31 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 5 , wherein the cytokine is a chicken myelomonocytic growth factor (cMGF), chicken interferon (cIFN) or quail interferon Type I (qIFN).
Claim 8
Dependent Claim
44 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence encodes an antigenic polypeptide selected from the group consisting of: Marek's disease virus, Newcastle disease virus, Infectious laryngotracheitis virus, Infectious bronchitis virus and Infectious bursal disease virus.
Claim 9
Dependent Claim
19 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the polypeptide is E. coli beta-galactosidase.
Claim 10
Dependent Claim
36 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is Marek's disease virus glycoprotein A (gA), Marek's disease virus glycoprotein B (gB), or Marek's disease virus glycoprotein D (gD).
Claim 11
Dependent Claim
27 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is Newcastle disease virus fusion protein or Newcastle disease virus hemagglutinin-neuraminidase.
Claim 12
Dependent Claim
33 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is infectious laryngotracheitis virus glycoprotein B (gB), infectious laryngotracheitis virus glycoprotein I (gI), or glycoprotein D (gD).
Claim 13
Dependent Claim
28 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is infectious bronchitis virus spike protein or infectious bronchitis virus matrix protein.
Claim 14
Dependent Claim
33 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is infectious bursal disease virus VP2, infectious bursal disease virus VP3 or infectious bursal disease virus VP4.
Claim 15
Dependent Claim
69 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 7 , wherein the antigenic polypeptide is selected form the group consisting of: avian encephalomyelitis virus, avian reovirus, avian paramyxovirus, avian influenza virus, avian adenovirus, fowl pox virus, avian coronavirus, avian rotavirus, chick anemia virus (agent), Salmonella spp. E. coli, Pasteurella spp., Bordetella spp., Eimeria spp., Histomonas spp., Trichomonas spp., Poultry nematodes, cestodes, trematodes, and poultry mites/lice, poultry protozoa.
Claim 16
Dependent Claim
26 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence is under control of an endogenous upstream herpesvirus promoter.
Claim 17
Dependent Claim
25 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 , wherein the foreign DNA sequence is under control of a heterologous upstream promoter.
Claim 18
Dependent Claim
65 words
The recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 16 wherein the promoter is selected from the group consisting of: chicken anemia virus promoter, psuedorabies virus gX promoter, herpes simplex virus-1 alpha 4 promoter, human cytomegalovirus immediate early promoter, Marek's disease virus gA promoter, gB promoter, Marek's disease virus gD promoter, infectious laryngotracheitis gB promoter, bovine herpesvirus-1.1 VP8 promoter and infectious laryngotracheitis gD promoter.
Claim 19
Dependent Claim
25 words
An immunological composition which comprises an effective immunizing amount of the recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 and a suitable carrier.
Claim 20
Dependent Claim
26 words
A multivalent immunological composition which comprises an effective immunizing amount of the recombinant herpesvirus of turkeys—Marek's disease virus chimera of claim 2 and a suitable carrier.
Claim 21
Dependent Claim
28 words
A method of immunizing a bird against an avian pathogen which comprises administering to the bird an effecting immunizing dose of the immunological composition of claim 18 .
References Cited (Backward Citations)
US4859587A
Cited
US5266489A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-02-06 | 2004-08-07 | 2005-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-02-06 | 2008-08-07 | 2009-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-02-06 | 2012-08-07 | 2013-02-06 | $7700.00 | Window Closed / Lapsed |