US6183516B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for improved bonding of prosthetic devices to bone
Assignee: Zimmer Inc
•
Filing: 1998-10-08
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Granted: 2001-02-06
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Expires: 2018-10-08
Abstract
Abstract The surface molecules of a modified polymeric prosthetic device participate in the free radical polymerization reaction of a bone cement such as polymethylmethacrylate, thereby providing improved bonding between the prosthesis and the bone to which it is attached.
Inventors
- 👤 Brian D. Burkinshaw
- 👤 Jack R. Frautschi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:15
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L27/00; A61L27/28; A61L27/50; A61F2/3094; A61F2/46; A61F2002/4631
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
115 words
A method for providing improved bonding between a polymeric prosthetic device and bone comprising: producing a surface modified prosthetic device by reacting the surface of a prosthetic device with a surface modifying agent which comprises a first reactive group and a second reactive group under conditions effective to cause covalent bonding between the first reactive group and the surface molecules of the polymeric prosthetic device; and contacting the surface modified prosthetic device with bone in the presence of PMMA under conditions effective to cause covalent bonding between the second reactive group on the surface modified prosthetic device and the PMMA, wherein the second reactive group is capable of participating in the polymerization reaction of PMMA.
Claim 2
Independent Claim
115 words
A method for providing improved bonding between a polymeric prosthetic device and bone comprising: producing a surface modified prosthetic device by reacting the surface of a prosthetic device with a surface modifying agent which comprises a first reactive group and a second reactive group under conditions effective to cause covalent bonding between the first reactive group and the surface molecules of the polymeric prosthetic device; and contacting the surface modified prosthetic device with bone in the presence of PMMA under conditions effective to cause covalent bonding between the second reactive group on the surface modified prosthetic device and the PMMA, wherein the second reactive group is capable of participating in the polymerization reaction of PMMA.
Claim 3
Dependent Claim
25 words
The method of claim 1 , wherein the first reactive group is derived from an azide, diazo, aliphatic azo, diazirine, ketene, ketone, or peroxy compound.
Claim 4
Dependent Claim
34 words
The method of claim 1 , wherein the first reactive group is derived from an azide compound selected from the group consisting of aryl azides, acyl azides, azido formates, sulfonyl azides, and phosphoryl azides.
Claim 5
Dependent Claim
27 words
The method of claim 1 , wherein the first reactive group is derived from a diazo compound selected from the group consisting of diazoalkanes, diazoketones, and diazoacetates.
Claim 6
Dependent Claim
15 words
The method of claim 1 , wherein the second reactive group is a vinyl group.
Claim 7
Dependent Claim
15 words
The method of claim 1 , wherein the polymeric prosthetic device is made from polyethylene.
Claim 8
Dependent Claim
58 words
A surface modified polymeric prosthetic device capable of improved bonding to PMMA wherein surface molecules of the prosthetic device are covalently bonded to the first reactive group of a surface modifying agent which comprises a first reactive group and a second reactive group, wherein the second reactive group is capable of participating in the polymerization reaction of PMMA.
Claim 9
Dependent Claim
58 words
A surface modified polymeric prosthetic device capable of improved bonding to PMMA wherein surface molecules of the prosthetic device are covalently bonded to the first reactive group of a surface modifying agent which comprises a first reactive group and a second reactive group, wherein the second reactive group is capable of participating in the polymerization reaction of PMMA.
Claim 10
Dependent Claim
29 words
The surface modified polymeric prosthetic device of claim 7 , wherein the first reactive group is derived from an azide, diazo, aliphatic azo, diazirine, ketene, ketone, or peroxy compound.
Claim 11
Dependent Claim
38 words
The surface modified polymeric prosthetic device of claim 7 , wherein the first reactive group is derived from an azide compound selected from the group consisting of aryl azides, acyl azides, azido formates, sulfonyl azides, and phosphoryl azides.
Claim 12
Dependent Claim
31 words
The surface modified polymeric prosthetic device of claim 7 , wherein the first reactive group is derived from a diazo compound selected from the group consisting of diazoalkanes, diazoketones, and diazoacetates.
Claim 13
Dependent Claim
19 words
The surface modified polymeric prosthetic device of claim 7 , wherein the second reactive group is a vinyl group.
Claim 14
Dependent Claim
19 words
The surface modified polymeric prosthetic device of claim 7 , wherein the polymeric prosthetic device is made from polyethylene.
Claim 15
Independent Claim
116 words
A method for providing improved bonding between a polymeric prosthetic device and bone comprising: producing a surface modified prosthetic device by reacting the surface of a prosthetic device with a surface modifying agent which comprises a first reactive group selected from the group consisting of azide, diazo, aliphatic azo, diazirine, ketene, ketone, and peroxy groups, and a second reactive group under conditions effective to cause covalent bonding between the first reactive group and the surface molecules of the polymeric prosthetic device; and contacting the surface modified prosthetic device with bone in the presence of PMMA under conditions effective to cause covalent bonding between the second reactive group on the surface modified prosthetic device and the PMMA.
Claim 16
Independent Claim
116 words
A method for providing improved bonding between a polymeric prosthetic device and bone comprising: producing a surface modified prosthetic device by reacting the surface of a prosthetic device with a surface modifying agent which comprises a first reactive group selected from the group consisting of azide, diazo, aliphatic azo, diazirine, ketene, ketone, and peroxy groups, and a second reactive group under conditions effective to cause covalent bonding between the first reactive group and the surface molecules of the polymeric prosthetic device; and contacting the surface modified prosthetic device with bone in the presence of PMMA under conditions effective to cause covalent bonding between the second reactive group on the surface modified prosthetic device and the PMMA.
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