US6165440A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiation and nanoparticles for enhancement of drug delivery in solid tumors
Assignee: The University of Texas System
•
Filing: 1998-07-09
•
Granted: 2000-12-26
•
Expires: 2018-07-09
Abstract
Abstract The present invention discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel walls. Cavitation induced by ultrasonic waves or local heating of the particles by pulsed electromagnetic radiation results in perforation of tumor blood vessels, microconvection in the interstitium, and perforation of cancer cell membrane, and therefore, provides enhanced delivery of macromolecular therapeutic agents from blood into cancer cells with minimal thermal and mechanical damage to normal tissues.
Inventors
- 👤 Rinat O. Esenaliev
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:37
CPC Classifications
A; A61; A61K; A61K48/00; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K41/00; A61K41/0028; A61K41/0038; A61K41/0047; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6927; A61P; A61P35/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
38 words
A method of enhancing anti-cancer drug delivery in a solid tumor, comprising the steps of: administering at least one anti-cancer drug to said tumor; injecting nanoparticles or microparticles to said tumor intravenously; and irradiating said tumor with radiation.
Claim 2
Independent Claim
38 words
A method of enhancing anti-cancer drug delivery in a solid tumor, comprising the steps of: administering at least one anti-cancer drug to said tumor; injecting nanoparticles or microparticles to said tumor intravenously; and irradiating said tumor with radiation.
Claim 3
Dependent Claim
28 words
The method of claim 1, wherein said anti-cancer drug is selected from the group consisting of a monoclonal antibody, a cytokine, an antisense oligonucleotide, and a gene-targeting vector.
Claim 4
Dependent Claim
31 words
The method of claim 1, wherein said tumor is in an organ selected from the group consisting of breast, lung, brain, liver, skin, kidney, GI organ, prostate, bladder and gynecological organ.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein said nanoparticles or microparticles are long-circulating particles with or without antibody coating.
Claim 6
Dependent Claim
13 words
The method of claim 4, wherein said antibody is directed against tumor vasculature.
Claim 7
Dependent Claim
19 words
The method of claim 1, wherein said nanoparticle has a diameter from about 0.1 nm to about 7000 nm.
Claim 8
Dependent Claim
36 words
The method of claim 1, wherein said nanoparticle or microparticle is selected from the group consisting of a metal particle, a carbon particle, a graphite particle, a polymer particle, a liquid particle and a porous particle.
Claim 9
Dependent Claim
19 words
The method of claim 1, wherein said radiation is optical pulsed radiation generated from a laser or non-laser source.
Claim 10
Dependent Claim
23 words
The method of claim 8, wherein said optical radiation is delivered through skin surface or via optical fibers or endoscopes to said tumor.
Claim 11
Dependent Claim
20 words
The method of claim 8, wherein said optical radiation is in the spectral range from 0.2 μm to 2 μm.
Claim 12
Dependent Claim
16 words
The method of claim 1, wherein said radiation is utrasonic radiation generated from an ultrasonic transducer.
Claim 13
Dependent Claim
19 words
The method of claim 11, wherein said ultrasonic radiation is in the frequency range from 20 to 500 kHz.
Claim 14
Dependent Claim
17 words
The method of claim 11, wherein said ultrasonic radiation is delivered through skin surface to said tumor.
Claim 15
Dependent Claim
50 words
An anti-cancer drug delivery system, comprising: a source of radiation; an electronic system for monitoring of said radiation; a means for delivery of said radiation to said tumor; nanoparticles or microparticles absorbing said radiation; an injection means for administration of said anti-cancer drug and said nanoparticles or microparticles in blood.
Claim 16
Dependent Claim
50 words
An anti-cancer drug delivery system, comprising: a source of radiation; an electronic system for monitoring of said radiation; a means for delivery of said radiation to said tumor; nanoparticles or microparticles absorbing said radiation; an injection means for administration of said anti-cancer drug and said nanoparticles or microparticles in blood.
Claim 17
Independent Claim
25 words
A method of treating a solid tumor, comprising the steps of: injecting nano- or microparticles to said tumor intravenously; and irradiating said tumor with radiation.
Claim 18
Independent Claim
25 words
A method of treating a solid tumor, comprising the steps of: injecting nano- or microparticles to said tumor intravenously; and irradiating said tumor with radiation.
References Cited (Backward Citations)
US4971991A
Cited
US5380411A
Cited
US5487390A
Cited
US5474765A
Cited
US5403590A
Cited
US5614502A
Cited
US5543158A
Cited
US5565215A
Cited
US5578325A
Cited
US5599712A
Cited
US5836905A
Cited
US5651986A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-26 | 2004-06-26 | 2004-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-26 | 2008-06-26 | 2008-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-26 | 2012-06-26 | 2012-12-26 | $7700.00 | Window Closed / Lapsed |