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US6144449A Expired / Lapsed US ⏱️ 0.0 years remaining

Low coherence interferometric device

Assignee: Roche Diagnostics GmbH
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Filing: 1997-01-23
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Granted: 2000-11-07
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Expires: 2017-01-23
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Abstract

Abstract Low coherence interferometer apparatus for investigation of a sample (15), in particular for multidimensional imaging, having an interferometer configuration (2) comprising a low coherence light source, a probe head (9) having a light exit opening (16) for irradiating light into the sample, an optical coupler, a reference reflector and a detector (13). The optical paths between the elements of the interferometer configuration (2) form interferometer arms. The optical coupler and the reference arm of the interferometer configuration (2) are integrated into a common optical chip (28). In addition to the reference reflector (11), the reference arm comprises a deflection reflector (33) formed on an end surface (35) of the optical chip (28) in such a manner that the reference light is cross-coupled between a first light guide (10a) forming a first portion of the reference arm (10) and a second light guide (10b) forming a second portion of the reference arm (10).

Inventors

  • 👤 Alexander Knuettel
  • 👤 Dirk Boecker

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 13:28
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/4795; G01B; G01B9/00; G01B9/02; G01B9/02015; G01B9/02027; G01B9/02049; G01B9/02051; G01B9/02055; G01B9/02056; G01B9/02058; G01B9/02062; G01B9/02063; G01B9/0209; G02; G02B; G02B6/00; G02B6/10; G02B6/12; G02B6/12004; G01J; G01J9/00; G01J9/02; G01J2009/0226; G01J2009/023; G02B2006/12083; G02B2006/12104

Claims Analysis

Total Claims: 15
Claim 1
Independent Claim 433 words
Low coherence interferometer apparatus for investigation of a sample, in particular for purposes of multi-dimensional imaging, having an interferometer configuration comprising a low coherence light source, a probe head having a light exit opening for irradiating light into the sample, an optical coupler, a reference reflector and a detector wherein the optical paths between the elements of the interferometer configuration form interferometer arms, namely a light source arm between the light source and the optical coupler, a sample arm between the optical coupler and the sample, a reference arm between the optical coupler and the reference reflector, and a detector arm between the optical coupler and the detector, measuring light is irradiated into the sample via the light source arm and the sample arm and through an interface defining the sample and light reflected from inside the sample is guided to the detector via the sample arm and the detector arm, reference light is-guided from the optical coupler to the reference reflector and therefrom via the reference arm and the detector arm to the detector, the measuring light and the reference light are joined in such a manner that they are both incident on the detector at the same location to produce an interference signal, wherein light reflected at an LCI measuring depth beneath the interface of the sample is selectively detected, and the optical coupler and the reference arm of the interferometer configuration are commonly integrated in an optical chip, wherein the reference arm has, in addition to the reference reflector, a deflection reflector by means of which the reference light from a first light guide forming a first partial path of the reference arm is reflected into a second light guide forming a second partial path of the reference arm to achieve a sufficient reference light path length in the optical chip, and wherein the deflection reflector is formed at an end surface of the optical chip in such a fashion that the reference light is cross-coupled between the two light guides, positioning means are provided for depth scanning the sample by changing the separation between the probe head and the interface, an optical system is disposed between the probe head and the interface for focusing light irradiated into the sample in a focal plane at a focal depth whose separation from the interface coincides with the LCI measuring depth, and the optical system comprises focus correction means for matched changing of the focal depth during the depth scan in such a manner that the focal depth and the LCI measuring depth coincide within the depth scanning range of the system.
Claim 2
Dependent Claim 433 words
Low coherence interferometer apparatus for investigation of a sample, in particular for purposes of multi-dimensional imaging, having an interferometer configuration comprising a low coherence light source, a probe head having a light exit opening for irradiating light into the sample, an optical coupler, a reference reflector and a detector wherein the optical paths between the elements of the interferometer configuration form interferometer arms, namely a light source arm between the light source and the optical coupler, a sample arm between the optical coupler and the sample, a reference arm between the optical coupler and the reference reflector, and a detector arm between the optical coupler and the detector, measuring light is irradiated into the sample via the light source arm and the sample arm and through an interface defining the sample and light reflected from inside the sample is guided to the detector via the sample arm and the detector arm, reference light is-guided from the optical coupler to the reference reflector and therefrom via the reference arm and the detector arm to the detector, the measuring light and the reference light are joined in such a manner that they are both incident on the detector at the same location to produce an interference signal, wherein light reflected at an LCI measuring depth beneath the interface of the sample is selectively detected, and the optical coupler and the reference arm of the interferometer configuration are commonly integrated in an optical chip, wherein the reference arm has, in addition to the reference reflector, a deflection reflector by means of which the reference light from a first light guide forming a first partial path of the reference arm is reflected into a second light guide forming a second partial path of the reference arm to achieve a sufficient reference light path length in the optical chip, and wherein the deflection reflector is formed at an end surface of the optical chip in such a fashion that the reference light is cross-coupled between the two light guides, positioning means are provided for depth scanning the sample by changing the separation between the probe head and the interface, an optical system is disposed between the probe head and the interface for focusing light irradiated into the sample in a focal plane at a focal depth whose separation from the interface coincides with the LCI measuring depth, and the optical system comprises focus correction means for matched changing of the focal depth during the depth scan in such a manner that the focal depth and the LCI measuring depth coincide within the depth scanning range of the system.
Claim 3
Dependent Claim 20 words
Apparatus according to claim 1, wherein the deflection reflector is formed by a mirrored end surface of the optical chip.
Claim 4
Dependent Claim 31 words
Apparatus according to claim 1, wherein the first light guide and the second light guide are incident on the deflection reflector at an acute angle α to cross-couple the reference light.
Claim 5
Dependent Claim 45 words
Apparatus according to claim 1, wherein the first light guide and the second light guide travel parallel to one another in a light coupling device along a coupling length L directly before the deflection reflector, wherein the coupling length L is adapted to effect cross-coupling.
Claim 6
Dependent Claim 39 words
Apparatus according to claim 1, wherein the optical chip comprises a plurality of parallel disposed interferometer modules for multi-channel investigation of the sample, wherein the measuring light is irradiated into the sample at a plurality of interface input locations.
Claim 7
Dependent Claim 17 words
Apparatus according to claim 1, wherein the optical chip in the reference arm comprises a chirped grating.
Claim 8
Dependent Claim 55 words
Apparatus according to claim 1, wherein the optical chip comprises an interferometer module having an additional compensating optical path a portion of the light from the light source being branched-off by means of an additional optical coupler and guided to an additional light detector for compensation of portions of light which are incapable of interference.
Claim 9
Dependent Claim 40 words
Apparatus according to claim 1, wherein positioning means are provided for lateral scanning to change the position at which the measuring light is irradiated through the interface into the sample in at least one spatial direction parallel to the interface.
Claim 10
Dependent Claim 24 words
Apparatus according to claim 1, wherein positioning means are provided to change the separation of the probe head from the interface for depth scanning.
Claim 11
Dependent Claim 322 words
Low coherence interferometer apparatus for investigation of a sample, in particular for purposes of multi-dimensional imaging, having an interferometer configuration comprising a low coherence light source, a probe head having a light exit opening for irradiating light into the sample, an optical coupler, a reference reflector and a detector wherein the optical paths between the elements of the interferometer configuration form interferometer arms, namely a light source arm between the light source and the optical coupler, a sample arm between the optical coupler and the sample, a reference arm between the optical coupler and the reference reflector, and a detector arm between the optical coupler and the detector, the measuring light is irradiated into the sample via the light source arm and the sample arm through an interface defining the sample and light reflected from inside the sample is guided to the detector via the sample arm and the detector arm, reference light is guided from the optical coupler to the reference reflector and therefrom via the reference arm and the detector arm to the detector, the measuring light and reference light are joined in such a manner that they are both incident on the detector at the same location to produce an interference signal, wherein light reflected from an LCI measuring depth beneath the interface of the sample is selectively detected, wherein positioning means are provided for depth scanning the sample by changing the separation between the probe head and the interface, an optical system is disposed between the probe head and the interface for focussing light irradiated into the sample in a focal plane at a focal depth whose separation from the interface coincides with the LCI measuring depth, and the optical system comprises focus correction means for matched changing of the focal depth during the depth scan in such a manner that the focal depth and the LCI measuring depth coincide within the depth scanning range of the system.
Claim 12
Dependent Claim 322 words
Low coherence interferometer apparatus for investigation of a sample, in particular for purposes of multi-dimensional imaging, having an interferometer configuration comprising a low coherence light source, a probe head having a light exit opening for irradiating light into the sample, an optical coupler, a reference reflector and a detector wherein the optical paths between the elements of the interferometer configuration form interferometer arms, namely a light source arm between the light source and the optical coupler, a sample arm between the optical coupler and the sample, a reference arm between the optical coupler and the reference reflector, and a detector arm between the optical coupler and the detector, the measuring light is irradiated into the sample via the light source arm and the sample arm through an interface defining the sample and light reflected from inside the sample is guided to the detector via the sample arm and the detector arm, reference light is guided from the optical coupler to the reference reflector and therefrom via the reference arm and the detector arm to the detector, the measuring light and reference light are joined in such a manner that they are both incident on the detector at the same location to produce an interference signal, wherein light reflected from an LCI measuring depth beneath the interface of the sample is selectively detected, wherein positioning means are provided for depth scanning the sample by changing the separation between the probe head and the interface, an optical system is disposed between the probe head and the interface for focussing light irradiated into the sample in a focal plane at a focal depth whose separation from the interface coincides with the LCI measuring depth, and the optical system comprises focus correction means for matched changing of the focal depth during the depth scan in such a manner that the focal depth and the LCI measuring depth coincide within the depth scanning range of the system.
Claim 13
Dependent Claim 51 words
Apparatus according to claim 10, wherein the focus correction means comprise a movable transparent bubble filled with liquid disposed in the optical path of the measuring light between the probe head and the sample in such a manner that its thickness decreases when the probe head is moved towards the sample.
Claim 14
Dependent Claim 59 words
Apparatus according to claim 10, wherein the focus correction means comprise a Keppler system having two lenses whose separation corresponds to the sum of their focal lengths with the following relationship obtaining for the focal lengths f 1 and f 2 : f.sub.2 /f.sub.1 =1/N, with N corresponding approximately to the average index of refraction of the sample (15).
Claim 15
Dependent Claim 14 words
Apparatus according to claim 10, wherein the optical system comprises a stationary lens system.

References Cited (Backward Citations)

DE2528209A1 Cited
DE3201801A1 Cited
US5073023A Cited
US5459570A Cited
US5289256A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2003-11-07 2004-05-08 2004-11-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2007-11-07 2008-05-08 2008-11-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2011-11-07 2012-05-08 2012-11-07 $7700.00 Window Closed / Lapsed

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