US6140127A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
Assignee: Cordis US Corp
•
Filing: 1998-02-18
•
Granted: 2000-10-31
•
Expires: 2018-02-18
Abstract
Abstract Endothelial cell attachment to an intravascular stent is promoted by coating the stent with an endothelial cell specific adhesion peptide. Coating is preferably carried out by activating the intravascular stent using plasma glow discharge, applying on the stent a layer or plurality of layers of a polymer such as poly(2-hydroxyethylmethacrylate), applying a tresylation solution containing pyridine and tresyl chloride, and applying a five amino acid peptide having the sequence glycine-arginine-glutamic acid-aspartic acid-valine.
Inventors
- 👤 Eugene A. Sprague
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:17
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/08; A61L31/10; A61F; A61F2/00; A61F2/82; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
96 words
A method of coating an intravascular stent comprising the steps of: providing an intravascular stent; activiating the intravascular stent; applying a polymer to the intravascular stent to form a polymer layer on the intravascular stent; applying a tresylation solution to the intravascular stent, wherein the tresylation solution comprises pyridine and tresyl chloride; applying an adhesion peptide coating for adhering cells to the intravascular stent, wherein the adhesion peptide coating is a peptide consisting of five amino acid peptide having the sequence glycine-arginine-glutamic acid-aspartic acid-valine; and wherein the intravascular stent is activated by using plasma glow discharge.
Claim 2
Independent Claim
96 words
A method of coating an intravascular stent comprising the steps of: providing an intravascular stent; activiating the intravascular stent; applying a polymer to the intravascular stent to form a polymer layer on the intravascular stent; applying a tresylation solution to the intravascular stent, wherein the tresylation solution comprises pyridine and tresyl chloride; applying an adhesion peptide coating for adhering cells to the intravascular stent, wherein the adhesion peptide coating is a peptide consisting of five amino acid peptide having the sequence glycine-arginine-glutamic acid-aspartic acid-valine; and wherein the intravascular stent is activated by using plasma glow discharge.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein the intravascular stent includes a plurality of polymer layers.
Claim 4
Dependent Claim
15 words
The method of claim 1, wherein the polymer layer is a layer of acrylic resin.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein the acrylic resin is poly(2-hydroxyethylmethacrylate).
Claim 6
Dependent Claim
11 words
The method of claim 1, wherein the tresylation solution is dioxane.
References Cited (Backward Citations)
US4739762B1
Cited
US4739762A
Cited
US4776337A
Cited
US5102417A
Cited
US4733665B1
Cited
US4733665C2
Cited
US4733665A
Cited
US4776337B1
Cited
US5195984A
Cited
US5116318A
Cited
US5366472A
Cited
US5476476A
Cited
US5330911A
Cited
US5278063A
Cited
US5643312A
Cited
US5728751A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-31 | 2004-05-01 | 2004-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-31 | 2008-05-01 | 2008-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-31 | 2012-05-01 | 2012-10-31 | $7700.00 | Window Closed / Lapsed |