US6103197A
Expired / Lapsed
US
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Method and apparatus for optically determining total hemoglobin concentration
Assignee: AVL Medical Instruments AG
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Filing: 1998-02-27
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Granted: 2000-08-15
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Expires: 2018-02-27
Abstract
Abstract In a method of optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, using at least two wavelengths for measuring, a first wavelength of λ<805 nm and a second wavelength of λ>805 nm is employed, such that the following is valid for the absorption coefficients of the hemoglobin derivatives O 2 Hb and RHb at the two measurement wavelengths λ 1 and λ 2 : σO(λ 1 )˜σR(λ 2 ) and σR(λ 1 )˜σO(λ 2 ). The sum of absorption values A 1 and A 2 measured at wavelengths λ 1 and λ 2 will be a quantity which is proportional to the total hemoglobin concentration tHb and independent of the oxygen saturation O 2sat .
Inventors
- 👤 Ziegler Werner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 14:15
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/314; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/50; G01N33/72; G01N33/721
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
185 words
Measuring apparatus for optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, comprising a capillary channel for holding a blood sample, having an inner wall and an inner diameter, an excitation device for supplying at least first and second measurement wavelengths, defining a first optical axis directed towards said capillary channel and an excitation light cone defined by an opening angle α, a detection device, defining a second optical axis directed towards said capillary channel and a detection light cone defined by an acceptance angle, wherein inclination angles β 1 , β 2 of said first and second optical axes and a distance e of said axes at intersection points with said capillary channel are chosen with respect to said diameter of said capillary channel such that said excitation light cone and said detection cone light overlap on said inner wall of said capillay channel if said capillary channel is filled with an aqueous solution, and that they do not overlap if said capillary channel is filled with whole blood, on account of reduced mean penetration depth of first and second measurement wavelengths.
Claim 2
Dependent Claim
185 words
Measuring apparatus for optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, comprising a capillary channel for holding a blood sample, having an inner wall and an inner diameter, an excitation device for supplying at least first and second measurement wavelengths, defining a first optical axis directed towards said capillary channel and an excitation light cone defined by an opening angle α, a detection device, defining a second optical axis directed towards said capillary channel and a detection light cone defined by an acceptance angle, wherein inclination angles β 1 , β 2 of said first and second optical axes and a distance e of said axes at intersection points with said capillary channel are chosen with respect to said diameter of said capillary channel such that said excitation light cone and said detection cone light overlap on said inner wall of said capillay channel if said capillary channel is filled with an aqueous solution, and that they do not overlap if said capillary channel is filled with whole blood, on account of reduced mean penetration depth of first and second measurement wavelengths.
Claim 3
Dependent Claim
35 words
The apparatus of claim 1, wherein said inner wall of said capillary channel is provided with a red calibration surface, at least in a region where said detection light cone overlapps said excitation light cone.
Claim 4
Dependent Claim
44 words
The apparatus of claim 1, wherein said red calibration surface covers an area on said inner wall of said capillary channel that extends over some 20 to 40 percent of the circumference and is situated opposite of said excitation device and said detection device.
Claim 5
Dependent Claim
62 words
The apparatus of claim 2, wherein said capillary channel is enlarged to form a measuring chamber in a region where said detection light cone overlapps said excitation light cone, one wall of said measuring chamber being provided with an optical sensor having a cover layer, which is permeable to a parameter to be measured, and is configured as a red calibration surface.
Claim 6
Dependent Claim
24 words
The apparatus of claim 4, wherein said optical sensor exhibits an indicator layer containing an indicator for pO 2 measurement in non-hemolyzed whole blood.
Claim 7
Dependent Claim
24 words
The apparatus of claim 4, wherein said optical sensor exhibits an indicator layer containing an indicator for pCO 2 measurement in non-hemolyzed whole blood.
Claim 8
Dependent Claim
23 words
The apparatus of claim 4, wherein said optical sensor exhibits an indicator layer containing an indicator for pH measurement in non-hemolyzed whole blood.
Claim 9
Dependent Claim
30 words
The apparatus of claim 1, wherein said capillary channel is positioned in a oneway cartridge which is insertable into an evaluation unit including said excitation device and said detection device.
Claim 10
Dependent Claim
30 words
The apparatus of claim 4, wherein said capillary channel is positioned in a oneway cartridge which is insertable into an evaluation unit including said excitation device and said detection device.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-15 | 2004-02-14 | 2004-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-15 | 2008-02-14 | 2008-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-15 | 2012-02-14 | 2012-08-15 | $7700.00 | Window Closed / Lapsed |