US6081786A
Expired / Lapsed
US
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Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
Assignee: INTELLIGENT THERAPEUTIC SOLUTIONS Inc
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Filing: 1999-04-01
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Granted: 2000-06-27
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Expires: 2019-04-01
Abstract
Abstract Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen for a known disease such as HIV infection are disclosed. The method comprises (a) providing patient information to a computing device (the computer device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for the disease; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for the disease; and a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of the different therapeutic treatment regimens; and (b) generating in the computing device a listing (preferably a ranked listing) of therapeutic treatment regimens for the patient; and (c) generating in the computing device advisory information for one or more treatment regimens in the listing based on the patient information and the expert rules.
Inventors
- 👤 David W. Barry
- 👤 Carolyn S. Underwood
- 👤 Bruce J. McCreedy
- 👤 David D. Hadden
- 👤 Jason L. Lucas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:07
CPC Classifications
G; G16; G16H; G16H50/00; G16H50/70; G16H20/00; G16H20/10; G16H50/20; G16H70/00; G16H70/20; G16H10/00; G16H10/20; G16H10/60; G16H15/00; G16H70/60; Y; Y10; Y10S; Y10S706/00; Y10S706/902; Y10S706/924
Claims Analysis
Total Claims: 69
Claim 1
Independent Claim
145 words
A method for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said method comprising: (a) providing patient information to a computing device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for evaluating and selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) generating in said computing device a ranked listing of available therapeutic treatment regimens for said patient; and (c) generating in said computing device advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 2
Independent Claim
145 words
A method for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said method comprising: (a) providing patient information to a computing device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for evaluating and selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) generating in said computing device a ranked listing of available therapeutic treatment regimens for said patient; and (c) generating in said computing device advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 3
Dependent Claim
48 words
A method according to claim 1, further comprising the steps of: (d) entering a user-defined therapeutic treatment regimen for said disease or medical condition that is not included in said first knowledge base; (e) generating in said computing device advisory information for said user-defined combination therapeutic treatment regimen.
Claim 4
Dependent Claim
69 words
A method according to claim 1, further comprising the steps of: (f) entering a non-recommended therapeutic treatment regimen for said disease or medical condition that is included in said first knowledge base but not recommended from said ranked listing; and (g) generating in said computing device advisory information for said non-recommended therapeutic treatment regimen, said advisory information including at least one reason for non-recommendation of said therapeutic treatment regimen.
Claim 5
Dependent Claim
39 words
A method according to claim 1, said patient information comprising gender, age, weight, CD4 information, viral load information, HIV genotype and phenotype information, hemoglobin information, neuropathy information, neutrophil information, pancreatitis, hepatic function, renal function, drug allergy and intolerance information.
Claim 6
Dependent Claim
15 words
A method according to claim 1, said patient information including prior therapeutic treatment regimen information.
Claim 7
Dependent Claim
19 words
A method according to claim 1, wherein said patient information includes prior patient information stored in said computing device.
Claim 8
Dependent Claim
37 words
A method according to claim 1, said advisory information including: warnings to take the patient off a contraindicated drug before initiating a corresponding therapeutic treatment regimen; and information clinically useful to implement a corresponding therapeutic treatment regimen.
Claim 9
Dependent Claim
36 words
A method according to claim 1, wherein said computing device comprises a fourth knowledge base comprising patient therapeutic treatment regimen history, said advisory information including previous therapeutic treatment regimen information extracted from said fourth knowledge base.
Claim 10
Dependent Claim
36 words
A method according to claim 7, wherein said known disease or medical condition is HIV-1 infection, said therapeutic treatment regimen includes antiretroviral drugs, and said therapeutic treatment regimen includes contraindicated or potentially adversely interacting non-antiretroviral drugs.
Claim 11
Dependent Claim
21 words
A method according to claim 7, wherein said therapeutic treatment regimen includes a protease inhibitor, and said contraindicated drug is terfenadine.
Claim 12
Dependent Claim
19 words
A method according to claim 7, wherein said therapeutic treatment regimen includes indinavir and said contraindicated drug is cisapride.
Claim 13
Dependent Claim
37 words
A method according to claim 1, wherein said known disease or medical condition is one where multiple prophylactic or therapeutic treatment regimens are available to be used singly or in combination in the treatment of said disease.
Claim 14
Dependent Claim
17 words
A method according to claim 1, wherein said known disease or medical condition is a cardiovascular disease.
Claim 15
Dependent Claim
17 words
A method according to claim 1, wherein said known disease or medical condition is a pulmonary disease.
Claim 16
Dependent Claim
17 words
A method according to claim 1, wherein said known disease or medical condition is a neurologic disease.
Claim 17
Dependent Claim
15 words
A method according to claim 1, wherein said known disease or medical condition is cancer.
Claim 18
Dependent Claim
18 words
A method according to claim 1, wherein said known disease or medical condition is a urinary tract infection.
Claim 19
Dependent Claim
15 words
A method according to claim 1, wherein said known disease or medical condition is hepatitis.
Claim 20
Dependent Claim
16 words
A method according to claim 1, wherein said known disease or medical condition is HIV-1 infection.
Claim 21
Dependent Claim
20 words
A method according to claim 1, wherein said first knowledge base comprises a plurality of different combination therapeutic treatment regimens.
Claim 22
Dependent Claim
21 words
A method according to claim 1, wherein drug dosage information is recommended and adjusted if necessary depending upon said patient information.
Claim 23
Dependent Claim
30 words
A method according to claim 1, further comprising the step of: (d) accessing, via said computing device, information for one or more therapeutic treatment regimens from a drug reference source.
Claim 24
Independent Claim
152 words
A system for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said system comprising: (a) a computing device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) means for providing patient information to said computing device; (c) means for generating in said computing device a ranked listing of therapeutic treatment regimens for said patient; and (d) means for generating in said computing device advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 25
Independent Claim
152 words
A system for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said system comprising: (a) a computing device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) means for providing patient information to said computing device; (c) means for generating in said computing device a ranked listing of therapeutic treatment regimens for said patient; and (d) means for generating in said computing device advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 26
Dependent Claim
51 words
A system according to claim 23, further comprising: (e) means for entering a user-defined therapeutic treatment regimen for said disease or medical condition that is not generated or displayed via said first knowledge base; (f) means for generating in said computing device advisory information for said user-defined combination therapeutic treatment regimen.
Claim 27
Dependent Claim
70 words
A system according to claim 23, further comprising: (f) means for entering a non-recommended therapeutic treatment regimen for said disease or medical condition that is included in said first knowledge base but not recommended from said ranked listing; and (g) means for generating in said computing device advisory information for said non-recommended therapeutic treatment regimen, said advisory information including at least one reason for non-recommendation of said therapeutic treatment regimen.
Claim 28
Dependent Claim
39 words
A system according to claim 23, said patient information comprising gender, age, weight, CD4 information, viral load information, HIV genotype and phenotype information, hemoglobin information, neuropathy information, neutrophil information, pancreatitis, hepatic function, renal function, drug allergy and intolerance information.
Claim 29
Dependent Claim
15 words
A system according to claim 23, said patient information including prior therapeutic treatment regimen information.
Claim 30
Dependent Claim
19 words
A system according to claim 23, wherein said patient information includes prior patient information stored in said computing device.
Claim 31
Dependent Claim
37 words
A system according to claim 23, said advisory information including: warnings to take the patient off a contraindicated drug before initiating a corresponding therapeutic treatment regimen; and information clinically useful to implement a corresponding therapeutic treatment regimen.
Claim 32
Dependent Claim
36 words
A system according to claim 23, wherein said computing device comprises a fourth knowledge base comprising patient therapeutic treatment regimen history, said advisory information including previous therapeutic treatment regimen information extracted from said fourth knowledge base.
Claim 33
Dependent Claim
36 words
A system according to claim 29, wherein said known disease or medical condition is HIV-1 infection, said therapeutic treatment regimen includes antiretroviral drugs, and said therapeutic treatment regimen includes contraindicated or potentially adversely interacting non-antiretroviral drugs.
Claim 34
Dependent Claim
21 words
A system according to claim 29, wherein said therapeutic treatment regimen includes a protease inhibitor, and said contraindicated drug is terfenadine.
Claim 35
Dependent Claim
19 words
A system according to claim 29, wherein said therapeutic treatment regimen includes indinavir and said contraindicated drug is cisapride.
Claim 36
Dependent Claim
39 words
A system according to claim 23, wherein said known disease or medical condition is one where multiple prophylactic therapeutic treatment regimens are available to be used singly or in combination in the treatment of said disease or medical condition.
Claim 37
Dependent Claim
17 words
A system according to claim 23, wherein said known disease or medical condition is a cardiovascular disease.
Claim 38
Dependent Claim
17 words
A system according to claim 23, wherein said known disease or medical condition is a pulmonary disease.
Claim 39
Dependent Claim
17 words
A system according to claim 23, wherein said known disease or medical condition is a neurologic disease.
Claim 40
Dependent Claim
15 words
A system according to claim 23, wherein said known disease or medical condition is cancer.
Claim 41
Dependent Claim
18 words
A system according to claim 23, wherein said known disease or medical condition is a urinary tract infection.
Claim 42
Dependent Claim
15 words
A system according to claim 23, wherein said known disease or medical condition is hepatitis.
Claim 43
Dependent Claim
16 words
A system according to claim 23, wherein said known disease or medical condition is HIV-1 infection.
Claim 44
Dependent Claim
20 words
A system according to claim 23, wherein said first knowledge base comprises a plurality of different combination therapeutic treatment regimens.
Claim 45
Dependent Claim
21 words
A system according to claim 23, wherein drug dosage information is recommended and adjusted if necessary depending upon said patient information.
Claim 46
Dependent Claim
30 words
A system according to claim 23, further comprising: (e) means for accessing, via said computing device, information for one or more therapeutic treatment regimens from a standard drug reference source.
Claim 47
Dependent Claim
182 words
A computer program product for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said computer program product comprising a computer usable storage medium having computer readable program code means embodied in the medium, the computer readable program code means comprising: (a) computer readable program code means for generating: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) computer readable program code means for providing patient information; (c) computer readable program code means for generating a ranked listing of available therapeutic treatment regimens for said patient; and (d) computer readable program code means for generating advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 48
Dependent Claim
182 words
A computer program product for guiding the selection of a therapeutic treatment regimen for a patient with a known disease or medical condition, said computer program product comprising a computer usable storage medium having computer readable program code means embodied in the medium, the computer readable program code means comprising: (a) computer readable program code means for generating: a first knowledge base comprising a plurality of different therapeutic treatment regimens for said disease or medical condition; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for said disease or medical condition; a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of said different therapeutic treatment regimens; and (b) computer readable program code means for providing patient information; (c) computer readable program code means for generating a ranked listing of available therapeutic treatment regimens for said patient; and (d) computer readable program code means for generating advisory information for one or more therapeutic treatment regimens in said ranked listing based on said patient information and said expert rules.
Claim 49
Dependent Claim
57 words
A computer program product according to claim 45, further comprising: (e) computer readable program code means for entering a user-defined therapeutic treatment regimen for said disease or medical condition that is not generated or displayed via said first knowledge base; (f) computer readable program code means for generating advisory information for said user-defined combination therapeutic treatment regimen.
Claim 50
Dependent Claim
76 words
A computer program product according to claim 46, further comprising: (g) computer readable program code means for entering a non-recommended therapeutic treatment regimen for said disease or medical condition that is included in said first knowledge base but not recommended from said ranked listing; and (h) computer readable program code means for generating advisory information for said non-recommended therapeutic treatment regimen, said advisory information including at least one reason for non-recommendation of said therapeutic treatment regimen.
Claim 51
Dependent Claim
41 words
A computer program product according to claim 45, said patient information comprising gender, age, weight, CD4 information, viral load information, HIV genotype and phenotype information, hemoglobin information, neuropathy information, neutrophil information, pancreatitis, hepatic function, renal function, drug allergy and intolerance information.
Claim 52
Dependent Claim
17 words
A computer program product according to claim 45, said patient information including prior therapeutic treatment regimen information.
Claim 53
Dependent Claim
16 words
A computer program product according to claim 45, wherein said patient information includes prior patient information.
Claim 54
Dependent Claim
39 words
A computer program product according to claim 45, said advisory information including: warnings to take the patient off a contraindicated drug before initiating a corresponding therapeutic treatment regimen; and information clinically useful to implement a corresponding therapeutic treatment regimen.
Claim 55
Dependent Claim
48 words
A computer program product according to claim 45 wherein said computer readable program code means comprises computer readable program code means for generating a fourth knowledge base comprising patient therapeutic treatment regimen history, said advisory information including previous therapeutic treatment regimen information extracted from said fourth knowledge base.
Claim 56
Dependent Claim
38 words
A computer program product according to claim 51, wherein said known disease or medical condition is HIV-1 infection, said therapeutic treatment regimen includes antiretroviral drugs, and said therapeutic treatment regimen includes contraindicated or potentially adversely interacting non-antiretroviral drugs.
Claim 57
Dependent Claim
23 words
A computer program product according to claim 51, wherein said therapeutic treatment regimen includes a protease inhibitor, and said contraindicated drug is terfenadine.
Claim 58
Dependent Claim
21 words
A computer program product according to claim 51, wherein said therapeutic treatment regimen includes indinavir and said contraindicated drug is cisapride.
Claim 59
Dependent Claim
41 words
A computer program product according to claim 45, wherein said known disease or medical condition is one where multiple prophylactic therapeutic treatment regimens are available to be used singly or in combination in the treatment of said disease or medical condition.
Claim 60
Dependent Claim
19 words
A computer program product according to claim 45, wherein said known disease or medical condition is a cardiovascular disease.
Claim 61
Dependent Claim
19 words
A computer program product according to claim 45, wherein said known disease or medical condition is a pulmonary disease.
Claim 62
Dependent Claim
19 words
A computer program product according to claim 45, wherein said known disease or medical condition is a neurologic disease.
Claim 63
Dependent Claim
17 words
A computer program product according to claim 45, wherein said known disease or medical condition is cancer.
Claim 64
Dependent Claim
20 words
A computer program product according to claim 45, wherein said known disease or medical condition is a urinary tract infection.
Claim 65
Dependent Claim
17 words
A computer program product according to claim 45, wherein said known disease or medical condition is hepatitis.
Claim 66
Dependent Claim
18 words
A computer program product according to claim 45, wherein said known disease or medical condition is HIV-1 infection.
Claim 67
Dependent Claim
22 words
A computer program product according to claim 45, wherein said first knowledge base comprises a plurality of different combination therapeutic treatment regimens.
Claim 68
Dependent Claim
23 words
A computer program product according to claim 45, wherein drug dosage information is recommended and adjusted if necessary depending upon said patient information.
Claim 69
Dependent Claim
32 words
A computer program product according to claim 45, further comprising: (e) computer readable program code means for accessing information for one or more therapeutic treatment regimens from a standard drug reference source.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-27 | 2003-12-27 | 2004-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-27 | 2007-12-27 | 2008-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-27 | 2011-12-27 | 2012-06-27 | $7700.00 | Window Closed / Lapsed |