US6080847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Proteins associated with cell proliferation
Assignee: Incyte Corp
•
Filing: 1997-12-04
•
Granted: 2000-06-27
•
Expires: 2017-12-04
Abstract
Abstract The invention provides three human proteins associated with cell proliferation, referred to collectively as "APOP" and individually as "APOP-1", "APOP-2", and "APOP-3", and polynucleotides which identify and encode APOP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of APOP.
Inventors
- 👤 Jennifer L. Hillman
- 👤 Henry Yue
- 👤 Preeti Lal
- 👤 Purvi Shah
- 👤 Neil C. Corley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:52
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4702; C07K14/4747
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
17 words
An isolated and purified polynucleotide sequence encoding an APOP comprising SEQ ID NO:3 or SEQ ID NO:5.
Claim 2
Dependent Claim
17 words
An isolated and purified polynucleotide sequence encoding an APOP comprising SEQ ID NO:3 or SEQ ID NO:5.
Claim 3
Dependent Claim
9 words
A composition comprising the polynucleotide sequence of claim 1.
Claim 4
Dependent Claim
17 words
An isolated and purified polynucleotide sequence which is completely complementary to the polynucleotide sequence of claim 1.
Claim 5
Dependent Claim
14 words
An isolated and purified polynucleotide sequence comprising SEQ ID NO:4 or SEQ ID NO:6.
Claim 6
Dependent Claim
14 words
An isolated and purified polynucleotide sequence comprising SEQ ID NO:4 or SEQ ID NO:6.
Claim 7
Dependent Claim
17 words
An isolated and purified polynucleotide sequence which is completely complementary to the polynucleotide sequence of claim 4.
Claim 8
Dependent Claim
10 words
An expression vector containing the polynucleotide sequence of claim 1.
Claim 9
Dependent Claim
10 words
A host cell containing the expression vector of claim 6.
Claim 10
Dependent Claim
52 words
A method for producing a polypeptide comprising the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:5, the method comprising the steps of: a) culturing the host cell of claim 7 under conditions suitable for the expression of the polypeptide; and b) recovering the polypeptide from the host cell culture.
Claim 11
Dependent Claim
71 words
A method for detecting a polynucleotide encoding APOP in a biological sample containing nucleic acids, the method comprising the steps of: (a) hybridizing the polynucleotide of claim 3 to at least one of the nucleic acids in the biological sample, thereby forming a hybridization complex; and (b) detecting the hybridization complex, wherein the presence of the hybridization complex correlates with the presence of a polynucleotide encoding APOP in the biological sample.
Claim 12
Dependent Claim
23 words
The method of claim 9 wherein the nucleic acids of the biological sample are amplified by the polymerase chain reaction prior to hybridization.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-27 | 2003-12-27 | 2004-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-27 | 2007-12-27 | 2008-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-27 | 2011-12-27 | 2012-06-27 | $7700.00 | Window Closed / Lapsed |