US6073041A
Expired / Lapsed
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Physiological corrections in functional magnetic resonance imaging
Assignee: University of Minnesota System
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Filing: 1996-07-18
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Granted: 2000-06-06
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Expires: 2016-07-18
Abstract
Abstract A functional magnetic resonance imaging method comprises the steps of: (a) detecting a physiological timing profile; (b) measuring cerebral k-space data to provide cerebral k-space data; (c) ordering the measured cerebral k-space data into a unit cycle based on the detected physiological timing profile; (d) estimating effects on individual k-space points resulting from physiological effects by non-linear least-square fitting to provide estimated physiological effects; and (e) removing the estimated physiological effects from the cerebral k-space data by substraction of the estimated physiological effects from said k-space data.
Inventors
- 👤 Xiaoping Hu
- 👤 Tuong Huu Le
- 👤 Todd B. Parrish
- 👤 Peter W. Erhard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:00
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/4806; A; A61; A61B; A61B5/00; A61B5/05; A61B5/055; A61B5/72; A61B5/7271; A61B5/7285; A61B5/7289; G01R33/54; G01R33/56; G01R33/567; A61B6/00; A61B6/54; A61B6/541; G01R33/561; G01R33/5613; G01R33/5615; G01R33/5616; G01R33/5676
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
102 words
A functional magnetic resonance imaging method comprising the steps of: (a) detecting a physiological timing profile; (b) measuring cerebral k-space data; (c) ordering the measured cerebral k-space data into a unit cycle based on the detected physiological timing profile; (d) estimating corresponding physiological effects for individual k-space data points by non-linear least-square fitting of cerebral k-space data; (e) removing the estimated physiological effects from the cerebral k-space data by subtraction, providing cerebral k-space data from which the estimated physical effects have been removed; and (f) providing an image from said cerebral k-space data from which the estimated physical effects have been removed.
Claim 2
Dependent Claim
102 words
A functional magnetic resonance imaging method comprising the steps of: (a) detecting a physiological timing profile; (b) measuring cerebral k-space data; (c) ordering the measured cerebral k-space data into a unit cycle based on the detected physiological timing profile; (d) estimating corresponding physiological effects for individual k-space data points by non-linear least-square fitting of cerebral k-space data; (e) removing the estimated physiological effects from the cerebral k-space data by subtraction, providing cerebral k-space data from which the estimated physical effects have been removed; and (f) providing an image from said cerebral k-space data from which the estimated physical effects have been removed.
Claim 3
Dependent Claim
18 words
A method of claim 1 in which the physiological timing profile of step (a) is based on respiration.
Claim 4
Dependent Claim
19 words
The method of claim 1 in which the physiological timing profile of step (a) is based on cardiac activity.
Claim 5
Dependent Claim
35 words
The method of claim 1 in which the physiological timing profile of step (a) is obtained from the phase of the center of a navigator echo in rapid, low flip angle pulsed NMR imaging (FLASH).
Claim 6
Dependent Claim
28 words
The method of claim 1 in which the physiological timing profile of step (a) is obtained from the phase of the center k-space point in echo-planar imaging (EPI).
Claim 7
Dependent Claim
20 words
The method of claim 1 in which step (a) comprises extracting the physiological timing profile directly from magnetic resonance data.
Claim 8
Dependent Claim
23 words
The method of claim 1 in which the non-linear least squares fitting of step (d) is performed as a finite order Fourier series.
Claim 9
Dependent Claim
103 words
A functional magnetic resonance imaging method of comprising the steps of: (a) detecting a physiological timing profile; (b) measuring cerebral k-space data to provide cerebral k-space data; (c) ordering the measured cerebral k-space data into a unit cycle based on the detected physiological timing profile; (d) estimating effects on individual k-space points resulting from physiological effects by non-linear fitting of cerebral k-space data to provide estimated physiological effects; (e) removing the estimated physiological effects from the cerebral k-space data by subtraction of the estimated physiological effects from said k-space data to form image data; and (f) forming an image from said image data.
Claim 10
Dependent Claim
103 words
A functional magnetic resonance imaging method of comprising the steps of: (a) detecting a physiological timing profile; (b) measuring cerebral k-space data to provide cerebral k-space data; (c) ordering the measured cerebral k-space data into a unit cycle based on the detected physiological timing profile; (d) estimating effects on individual k-space points resulting from physiological effects by non-linear fitting of cerebral k-space data to provide estimated physiological effects; (e) removing the estimated physiological effects from the cerebral k-space data by subtraction of the estimated physiological effects from said k-space data to form image data; and (f) forming an image from said image data.
Claim 11
Dependent Claim
27 words
The method of claim 1 wherein said physiological timing profile of step (a) is based upon effects selected from the group consisting of respiration and cardiac activity.
Claim 12
Dependent Claim
19 words
The method of claim 9 wherein step (a) comprises extracting the physiological timing profile directly from magnetic resonance data.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-06 | 2003-12-06 | 2004-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-06 | 2007-12-06 | 2008-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-06 | 2011-12-06 | 2012-06-06 | $7700.00 | Window Closed / Lapsed |