US6063378A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic agent for herniated intervertebral disc
Assignee: Seikagaku Corp
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Filing: 1998-08-20
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Granted: 2000-05-16
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Expires: 2018-08-20
Abstract
Abstract A pharmaceutical composition and an agent that can be used for treatment of epidurally migrating herniated intervertebral disc are provided. The composition comprises a glycosaminoglycan degrading enzyme, preferably chondroitinase, more preferably chondroitinase ABC, in an amount effective to dissolve nucleus pulposus epidurally existing.
Inventors
- 👤 Yutaka Nohara
- 👤 Hiroki Ishikawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:50
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/51; A61K38/46; A61K38/47; A61P; A61P19/00; A61P19/04; A61P21/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
61 words
A method for treating epidurally-migrating herniated intervertebral disc wherein nucleus pulposus migrates into a vertebral epidural space, which comprises the step of administering a glycosaminoglycan-degrading enzyme to a vertebral epidural space of a mammal in need thereof until nucleus pulposus within the vertebral epidural space is dissolved by digestion by the enzyme and by facilitation of emersion and infiltration of phagocytes.
Claim 2
Independent Claim
61 words
A method for treating epidurally-migrating herniated intervertebral disc wherein nucleus pulposus migrates into a vertebral epidural space, which comprises the step of administering a glycosaminoglycan-degrading enzyme to a vertebral epidural space of a mammal in need thereof until nucleus pulposus within the vertebral epidural space is dissolved by digestion by the enzyme and by facilitation of emersion and infiltration of phagocytes.
Claim 3
Dependent Claim
17 words
The method according to claim 1, wherein said herniated intervertebral disc is sequestered type herniated intervertebral disc.
Claim 4
Dependent Claim
18 words
The method according to claim 1, wherein said herniated intervertebral disc is transligamentous extrusion type herniated intervertebral disc.
Claim 5
Dependent Claim
12 words
The method according to claim 1, wherein said mammal is a human.
Claim 6
Dependent Claim
13 words
The method according to claim 1, wherein said glycosaminoglycan degrading enzyme is chondroitinase.
Claim 7
Dependent Claim
12 words
The method according to claim 5, wherein said chondroitinase is chondroitinase ABC.
Claim 8
Dependent Claim
19 words
The method according to claim 1, wherein said enzyme is administrated in an amount of more than 5 units.
Claim 9
Independent Claim
56 words
A method for treating epidurally-migrating herniated intervertebral disc wherein nucleus pulposus migrates into a vertebral epidural space, which comprises the step of administrating a glycosaminoglycan-degrading enzyme to a vertebral epidural space of a mammal in need thereof in an amount effective to facilitate emersion and infiltration of phagocytes into nucleus pulposus within the vertebral epidural space.
Claim 10
Independent Claim
56 words
A method for treating epidurally-migrating herniated intervertebral disc wherein nucleus pulposus migrates into a vertebral epidural space, which comprises the step of administrating a glycosaminoglycan-degrading enzyme to a vertebral epidural space of a mammal in need thereof in an amount effective to facilitate emersion and infiltration of phagocytes into nucleus pulposus within the vertebral epidural space.
Claim 11
Dependent Claim
12 words
The method according to claim 8, wherein said mammal is a human.
Claim 12
Dependent Claim
12 words
The method according to claim 8, wherein said glycosaminoglycan-degrading enzyme is chondroitinase.
Claim 13
Dependent Claim
12 words
The method according to claim 10, wherein said chondroitinase is chondroitinase ABC.
Claim 14
Independent Claim
52 words
A method for facilitating infiltration of phagocytes into nucleus pulposus within a vertebral epidural space of a mammal, which comprises the step of administrating an effective amount of a glycosaminoglycan-degrading enzyme to the vertebral epidural space until emersion and infiltration of phagocytes into nucleus pulposus within the vertebral epidural space are facilitated.
Claim 15
Independent Claim
52 words
A method for facilitating infiltration of phagocytes into nucleus pulposus within a vertebral epidural space of a mammal, which comprises the step of administrating an effective amount of a glycosaminoglycan-degrading enzyme to the vertebral epidural space until emersion and infiltration of phagocytes into nucleus pulposus within the vertebral epidural space are facilitated.
Claim 16
Dependent Claim
12 words
The method according to claim 12, wherein said mammal is a human.
Claim 17
Dependent Claim
12 words
The method according to claim 12, wherein said glycosaminoglycan-degrading enzyme is chondroitinase.
Claim 18
Dependent Claim
12 words
The method according to claim 14, wherein said chondroitinase is chondroitinase ABC.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-05-16 | 2003-11-15 | 2004-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-05-16 | 2007-11-15 | 2008-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-05-16 | 2011-11-15 | 2012-05-16 | $7700.00 | Window Closed / Lapsed |