US6060474A
Expired / Lapsed
US
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Method for preventing scar tissue formation
Assignee: Hospital for Special Surgery
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Filing: 1998-11-05
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Granted: 2000-05-09
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Expires: 2018-11-05
Abstract
Abstract Disclosed herein are methods for reducing or preventing scar tissue formation by administering an antifibrotic amount of a fluoroquinolone. Also disclosed are means for inhibiting the activity of fibroblast cells, including their proliferation, metabolism, and invasion into tissue. The invention further contemplates methods and compositions for the delivery of a fluoroquinolone to prevent or treat scar tissue formation, including oral and intravenous delivery means.
Inventors
- 👤 Riley J. Williams
- 👤 Jo A. Hannafin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/4965; A61K31/497; A61K31/535; A61K31/5375; A61K31/538
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
28 words
A surgical implant having a surface comprising an antifibrotic effective amount of a fluoroquinolone and a carrier, wherein said surface is coated with or otherwise contains the fluoroquinolone.
Claim 2
Dependent Claim
28 words
A surgical implant having a surface comprising an antifibrotic effective amount of a fluoroquinolone and a carrier, wherein said surface is coated with or otherwise contains the fluoroquinolone.
Claim 3
Dependent Claim
21 words
The implant of claim 1, wherein said carrier is selected from the group consisting of a matrix, ointment, lavage, and gel.
Claim 4
Dependent Claim
24 words
The implant of claim 1, wherein the fluoroquinolone is selected from the group consisting of ciprofloxacin, enoxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, pefloxacin, and sparfloxacin.
Claim 5
Dependent Claim
10 words
The implant of claim 1 wherein the fluoroquinolone is ciprofloxacin.
Claim 6
Dependent Claim
9 words
The implant of claim 1 comprising an orthopedic implant.
Claim 7
Independent Claim
32 words
A method for inhibiting fibrosis in a mammal comprising the step of contacting a therapeutically effective amount of a fluoroquinolone with a biological tissue of said mammal in need of such inhibition.
Claim 8
Independent Claim
32 words
A method for inhibiting fibrosis in a mammal comprising the step of contacting a therapeutically effective amount of a fluoroquinolone with a biological tissue of said mammal in need of such inhibition.
Claim 9
Independent Claim
42 words
A method for inhibiting fibroblast proliferation, fibroblast metabolism, collagen synthesis, proteoglycan synthesis, or matrix synthesis in a mammal comprising the step of contacting a biological tissue of said mammal in need of such inhibition with a therapeutically effective amount of a fluoroquinolone.
Claim 10
Independent Claim
42 words
A method for inhibiting fibroblast proliferation, fibroblast metabolism, collagen synthesis, proteoglycan synthesis, or matrix synthesis in a mammal comprising the step of contacting a biological tissue of said mammal in need of such inhibition with a therapeutically effective amount of a fluoroquinolone.
Claim 11
Independent Claim
44 words
A method for treating scar tissue formation, keloidosis, joint stiffness, or fibrocystic condition in a mammal in need of such treatment comprising the step of administering to said mammal a composition comprising a pharmaceutically effective amount of a fluoroquinolone and a pharmaceutically acceptable carrier.
Claim 12
Independent Claim
44 words
A method for treating scar tissue formation, keloidosis, joint stiffness, or fibrocystic condition in a mammal in need of such treatment comprising the step of administering to said mammal a composition comprising a pharmaceutically effective amount of a fluoroquinolone and a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
17 words
The method according to claim 6 wherein the tissue is a pre-existing scar or a pre-existing keloid.
Claim 14
Dependent Claim
17 words
The method according to claim 6 comprising inhibiting formation of scar tissue resulting from a surgical procedure.
Claim 15
Dependent Claim
15 words
The method according to claim 6 wherein the mammal is a human or domesticated animal.
Claim 16
Dependent Claim
26 words
The method according to claim 6 wherein the fluoroquinolone is contacted with said tissue in a concentration of from about 0.1 μg/ml to about 100 μg/ml.
Claim 17
Dependent Claim
28 words
The method according to claim 6 wherein the amount of fluoroquinolone is contacted with said tissue in a concentration of from about 5 μg/ml to about 50 μg/ml.
Claim 18
Dependent Claim
26 words
The method according to claim 6 wherein the fluoroquinolone is contacted with said tissue for a period of from about 1 day to about 6 weeks.
Claim 19
Dependent Claim
15 words
The method according to claim 6 wherein the fluoroquinolone is administered before a surgical procedure.
Claim 20
Dependent Claim
25 words
The method according to claim 6 wherein the fluoroquinolone is selected from the group consisting of ciprofloxacin, enoxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, pefloxacin, and sparfloxacin.
Claim 21
Dependent Claim
37 words
The method according to claim 6 wherein the lesion or scar tissue is selected from the group consisting of an adhesion, joint capsule contracture, surgical lesion, traumatic injury, non-topical wound, topical wound, acne, and a hypertrophic scar.
Claim 22
Dependent Claim
31 words
The method according to claim 6 wherein the fluoroquinolone is administered by a means selected from the group consisting of intra-lesionally, pharmaceutically acceptable surgical implantion, orally, intravenously, intrarticularly, intradermally, and parenterally.
Claim 23
Independent Claim
42 words
A method for inhibiting fibrosis in a patient who has had cosmetic alteration of a preexisting wrinkle or wrinkles comprising the step of administering a pharmaceutically effective amount of a fluoroquinolone and a pharmaceutically acceptable carrier directly into said wrinkle or wrinkles.
Claim 24
Independent Claim
42 words
A method for inhibiting fibrosis in a patient who has had cosmetic alteration of a preexisting wrinkle or wrinkles comprising the step of administering a pharmaceutically effective amount of a fluoroquinolone and a pharmaceutically acceptable carrier directly into said wrinkle or wrinkles.
Claim 25
Dependent Claim
14 words
The method of claim 19, wherein the fibrosis comprises the formation of scar tissue.
Claim 26
Dependent Claim
16 words
The method of claim 20, wherein the formation of scar tissue comprises the formation of wrinkles.
References Cited (Backward Citations)
No citation records indexed.
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