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US6060053A
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Injectable chondrocyte-carrier suspension for treatment of vesicoureteral reflux and incontinence
Assignee: Massachusetts Institute of Technology
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Filing: 1996-05-29
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Granted: 2000-05-09
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Expires: 2016-05-29
Abstract
Abstract A method of treatment of vesicoureteral reflux, incontinence and other defects is described wherein chondrocytes are mixed with a liquid biodegradable polymeric material to form a suspension. The suspension is injected into the area where the defect is located and can be corrected by the presence of a bulking agent, in an amount effective to yield cartilage.
Inventors
- 👤 Anthony Atala
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:11
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/20; A61L27/36; A61L27/38; A61L27/3804; A61L27/3817; A61L27/3839; A61L27/50; A61P; A61P13/00; A61P13/10; A61P19/00; A61P19/02; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
87 words
A method for treating conditions which require reconstruction of an anatomical area by the filling of an anatomical space in soft tissue selected from the group consisting of theoracic region, gastrointestinal tract, urinary tract, and reproductive tract, comprising: injecting into a patient in need of treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradble non-proteinaceous poloymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
Claim 2
Independent Claim
87 words
A method for treating conditions which require reconstruction of an anatomical area by the filling of an anatomical space in soft tissue selected from the group consisting of theoracic region, gastrointestinal tract, urinary tract, and reproductive tract, comprising: injecting into a patient in need of treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradble non-proteinaceous poloymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
Claim 3
Dependent Claim
31 words
The method of claim 1 wherein the polymer is crosslinkable by temperature or pH and is selected from the group consisting of polysaccharides, polyhosphazines, polyacrylates, and polyethylene oxide-polypropylene glycol block copolymers.
Claim 4
Dependent Claim
63 words
The method of claim 2 wherein the polymers are selected from the group of polymers with acidic side groups that can be reacted with cations consisting of poly(phosphazenes), poly(acrylic acids), poly(methacrylic acids), copolymers of acrylic acid and methacrylic acid, poly(vinyl acetate), sulfonated polymers, and copolymers having acidic side groups formed by reaction of acrylic or methacrylic acid and vinyl ether monomers or polymers.
Claim 5
Dependent Claim
37 words
The method of claim 2 wherein the polymers are selected from the group of polymers with basic side groups that can be reacted with anions consisting of poly(vinyl amines), poly(vinyl pyridine), poly(vinyl imidazole), and imino substituted polyphosphazenes.
Claim 6
Dependent Claim
19 words
The method of claim 2 wherein the polymer is selected from the group consisting of alginate and hyaluronic acid.
Claim 7
Dependent Claim
13 words
The method of claim 1 wherein the chondrocytes are isolated from the patient.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein the condition is vesicoureteral reflux.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein the condition is incontinence.
Claim 10
Dependent Claim
16 words
The method of claim 1 wherein the area which requires reconstruction is in the thoracic region.
Claim 11
Dependent Claim
14 words
The method of claim 1 wherein the space is in the upper gastrointestinal tract.
Claim 12
Dependent Claim
13 words
A method of claim 1 wherein the treating comprises correcting an anatomical condition.
Claim 13
Dependent Claim
16 words
A method of claim 1 wherein the treating comprises creating an obstruction in an anatomical space.
Claim 14
Dependent Claim
13 words
The method of claim 1 wherein the space is in the vas deferens.
Claim 15
Dependent Claim
13 words
The method of claim 1 wherein the space is in the fallopian tube.
Claim 16
Dependent Claim
18 words
The method of claim 1 wherein the space is a region adjacent to or part of the rectum.
Claim 17
Independent Claim
56 words
A method for treating vesicoureteral reflux, comprising: injecting into a patient in need of treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradable non-proteinaceous polymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
Claim 18
Independent Claim
56 words
A method for treating vesicoureteral reflux, comprising: injecting into a patient in need of treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradable non-proteinaceous polymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
Claim 19
Independent Claim
55 words
A method for treating incontinence, comprising: injecting into a patient in need or treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradable non-proteinaceous polymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
Claim 20
Independent Claim
55 words
A method for treating incontinence, comprising: injecting into a patient in need or treatment thereof, at a space in the anatomical area, a suspension of chondrocytes in a biodegradable non-proteinaceous polymer solution that, when injected in vivo, forms an ionically crosslinked hydrogel having the cells dispersed therein which becomes a non-migratory volume stable tissue mass.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-05-09 | 2003-11-08 | 2004-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-05-09 | 2007-11-08 | 2008-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-05-09 | 2011-11-08 | 2012-05-09 | $7700.00 | Window Closed / Lapsed |