US6045565A
Expired / Lapsed
US
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Percutaneous myocardial revascularization growth factor mediums and method
Assignee: Boston Scientific Scimed Inc
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Filing: 1998-11-02
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Granted: 2000-04-04
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Expires: 2018-11-02
Abstract
Abstract Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
Inventors
- 👤 Louis Ellis
- 👤 Gary L. Hendrickson
- 👤 Kent D. Harrison
- 👤 Lixiao Wang
- 👤 Timothy J. Mickley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:35
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/32; A61B17/320016; A61B17/32002; A61B17/34; A61B17/3468; A61B17/3478; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2493; A61B17/3205; A61B17/3207; A61B17/320758; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B2017/00247; A61B2017/00292; A61B2017/003; A61B17/22; A61B2017/22072; A61B2017/22074; A61B2017/22077; A61B17/320068; A61B2017/320084; A61B18/00; A61B2018/00053; A61B2018/00184; A61B2018/00202; A61B2018/00208; A61B2018/00315; A61B2018/00345; A61B2018/00351; A61B2018/00392; A61B18/04; A61B18/12; A61B18/14; A61B2018/1405; A61B2018/1425; A61B18/18; A61B18/1815; A61B2018/1861; A61B90/00; A61B90/39; A61M; A61M25/00; A61M25/0067; A61M25/0082; A61M25/0084; A61M2025/0089
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
65 words
A method for promoting blood perfusion within the myocardium of a heart chamber comprising the steps: providing a compound including vascularization promoting material; providing a device capable of puncturing the endocardium of a heart chamber through to the myocardium and capable of injecting said compound into said myocardium; positioning said device within said heart chamber; puncturing said myocardium; and injecting said compound into said myocardium.
Claim 2
Independent Claim
65 words
A method for promoting blood perfusion within the myocardium of a heart chamber comprising the steps: providing a compound including vascularization promoting material; providing a device capable of puncturing the endocardium of a heart chamber through to the myocardium and capable of injecting said compound into said myocardium; positioning said device within said heart chamber; puncturing said myocardium; and injecting said compound into said myocardium.
Claim 3
Dependent Claim
24 words
A method for promoting blood perfusion within the myocardium of a heart chamber as recited in claim 1, wherein said compound includes radiopaque material.
Claim 4
Dependent Claim
25 words
A method for promoting blood perfusion within the myocardium of a heart chamber as recited in claim 1, wherein said puncturing step removes myocardial material.
Claim 5
Dependent Claim
34 words
A method for promoting blood perfusion within the myocardium of a heart chamber as recited in claim 3, wherein said vascularization promoting material is selected from the group consisting of growth factors and estrogen.
Claim 6
Dependent Claim
24 words
A method for promoting blood perfusion within the myocardium of a heart chamber as recited in claim 3, wherein said compound includes an adhesive.
Claim 7
Dependent Claim
33 words
A method for promoting blood perfusion within the myocardium of a heart chamber as recited in claim 5, wherein said adhesive is selected from the group consisting of fibrin glues, cyanoacrylate and hydrogels.
Claim 8
Independent Claim
101 words
A method for promoting blood perfusion within the myocardium of a heart chamber comprising the steps: providing a compound including vascularization promoting material and radiopaque material; providing a device capable of forming a hole in the endocardium of a heart chamber through to the myocardium and capable of injecting said compound into said myocardium; positioning said device within said heart chamber; forming said hole a depth into said myocardium; injecting said compound into said myocardium; visualizing said hole depth by visualizing said radiopaque material; and repeating said hole forming, injecting, and visualizing steps as required to achieve a desired hole depth.
Claim 9
Independent Claim
101 words
A method for promoting blood perfusion within the myocardium of a heart chamber comprising the steps: providing a compound including vascularization promoting material and radiopaque material; providing a device capable of forming a hole in the endocardium of a heart chamber through to the myocardium and capable of injecting said compound into said myocardium; positioning said device within said heart chamber; forming said hole a depth into said myocardium; injecting said compound into said myocardium; visualizing said hole depth by visualizing said radiopaque material; and repeating said hole forming, injecting, and visualizing steps as required to achieve a desired hole depth.
Claim 10
Independent Claim
56 words
A method of percutaneously treating cardiovascular disease comprising the steps of: providing a therapeutic material; providing a device capable of puncturing the endocardium of a heart chamber through to the myocardium and capable of injecting said therapeutic material into said myocardium; positioning said device within said heart chamber; and injecting said therapeutic material into said myocardium.
Claim 11
Independent Claim
56 words
A method of percutaneously treating cardiovascular disease comprising the steps of: providing a therapeutic material; providing a device capable of puncturing the endocardium of a heart chamber through to the myocardium and capable of injecting said therapeutic material into said myocardium; positioning said device within said heart chamber; and injecting said therapeutic material into said myocardium.
Claim 12
Dependent Claim
19 words
A method of percutaneously treating cardiovascular disease as claimed in claim 8, wherein said therapeutic material is a drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-04-04 | 2003-10-04 | 2004-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-04-04 | 2007-10-04 | 2008-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-04-04 | 2011-10-04 | 2012-04-04 | $7700.00 | Window Closed / Lapsed |