US6034212A
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SH3 kinase domain associated protein, a signalling domain therein, nucleic acids encoding the protein and the domain, and diagnostic and therapeutic uses thereof
Assignee: Max Delbrück Center for Molecular Medicine
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Filing: 1995-06-07
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Granted: 2000-03-07
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Expires: 2015-06-07
Abstract
Abstract The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins, by putative signalling domains of such proteins, ligands of the signalling domain, and diagnosis and therapy based on the activity of such proteins, signalling domains, and ligands.
Inventors
- 👤 Marius Sudol
- 👤 Peer Bork
- 👤 Henry Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 15:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; A; A61; A61K; A61K38/00; C07K2319/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:2.
Claim 2
Dependent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:2.
Claim 3
Dependent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:4.
Claim 4
Dependent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:4.
Claim 5
Dependent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:5.
Claim 6
Dependent Claim
19 words
An isolated Yes proto-oncogene associated protein or polypeptide (YAP) that comprises the amino acid sequence of SEQ ID NO:5.
Claim 7
Dependent Claim
87 words
A peptide consisting of 30 to 50 amino acid residues comprising a WW domain that comprises an amino acid sequence selected from the group consisting of SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO;11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, and SEQ ID NO:25.
Claim 8
Dependent Claim
87 words
A peptide consisting of 30 to 50 amino acid residues comprising a WW domain that comprises an amino acid sequence selected from the group consisting of SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO;11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, and SEQ ID NO:25.
Claim 9
Dependent Claim
15 words
The peptide of claim 4 that comprises the amino acid sequence of SEQ ID NO:6.
Claim 10
Dependent Claim
15 words
The peptide of claim 4 that comprises the amino acid sequence of SEQ ID NO:9.
Claim 11
Dependent Claim
15 words
The peptide of claim 4 that comprises the amino acid sequence of SEQ ID NO:10.
Claim 12
Dependent Claim
15 words
The peptide of claim 4 that comprises the amino acid sequence of SEQ ID NO:11.
Claim 13
Dependent Claim
15 words
The peptide of claim 4 that comprises the amino acid sequence of SEQ ID NO:12.
Claim 14
Dependent Claim
8 words
The peptide of claim 4 which is labeled.
Claim 15
Dependent Claim
113 words
A chimeric polypeptide consisting of a protein and a peptide; wherein the protein contains at least a portion of a non-YAP or non-WW domain protein; and wherein the peptide consists of 30 to 50 amino acid residues; and wherein said peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, and SEQ ID NO:25.
Claim 16
Dependent Claim
113 words
A chimeric polypeptide consisting of a protein and a peptide; wherein the protein contains at least a portion of a non-YAP or non-WW domain protein; and wherein the peptide consists of 30 to 50 amino acid residues; and wherein said peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, and SEQ ID NO:25.
Claim 17
Dependent Claim
11 words
The chimeric polypeptide of claim 11 wherein the protein is glutathione-S-transferase.
References Cited (Backward Citations)
WO1989006286A2
Cited
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