US6031059A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Optically transparent hydrogels and processes for their production
Assignee: Johnson and Johnson Vision Care Inc
•
Filing: 1998-09-30
•
Granted: 2000-02-29
•
Expires: 2018-09-30
Abstract
Abstract The invention provides hydrogels for use in the production of biomedical devices. In particular, the invention provides hydrogels formed from siloxane prepolymers and a hydrophilic monomer, which hydrogels are optically transparent.
Inventors
- 👤 Douglas G. Vanderlaan
- 👤 Frank Molock
- 👤 Giancarlo Fruzzetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 07:35
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/02; C08F; C08F230/00; C08F230/04; C08F230/08; C08F230/085
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
47 words
A process for producing a hydrogel comprising: a.) polymerizing a hydrophobic siloxane prepoplymer and a silylated hydrophilic monomer; and b.) hydrolyzing the resulting polymer wherein the step a.) polymerizing is carried out by using one of heat polymerization, ultraviolet light polymerization, radiation polymerization, or a combination thereof.
Claim 2
Dependent Claim
47 words
A process for producing a hydrogel comprising: a.) polymerizing a hydrophobic siloxane prepoplymer and a silylated hydrophilic monomer; and b.) hydrolyzing the resulting polymer wherein the step a.) polymerizing is carried out by using one of heat polymerization, ultraviolet light polymerization, radiation polymerization, or a combination thereof.
Claim 3
Dependent Claim
22 words
The process of claim 1 wherein the hydrophobic siloxane prepolymer and the silylated hydrophilic monomer are polymerized with a hydrophobic siloxane monomer.
Claim 4
Dependent Claim
58 words
The process of claim 2 wherein the hydrophobic siloxane monomer is of the formula: ##STR7## wherein R 19 and R 20 are each independently hydrogen or methyl, R 21 , R 22 , and R 23 are each independently a monovalent alkyl of 1 to 5 carbon atoms or aryl, j =1 to 10 and k=0 to 3.
Claim 5
Dependent Claim
14 words
The process of claim 3, wherein the hydrophobic siloxane monomer is 3-methacryloxypropyltris(trimethylsiloxy)silane or 3-methacryloxypropylbis(trimethylsiloxy)methylsilane.
Claim 6
Dependent Claim
78 words
The process of claim 1 or 3 wherein the hydrophobic siloxane prepolymer is of the formula: ##STR8## wherein R 1 is hydrogen or an alkyl of 1 to 5 carbon atoms, R 2 is an alkyl of 1 to 5 carbon atoms, n=1 to 12, and z=1 to 500 and the silylated hydrophilic monomer is of the formula: ##STR9## wherein R 24 is hydrogen or methyl, R 25 is hydrogen or methyl, and R 26 is a monoalkyl0000.
Claim 7
Dependent Claim
26 words
The process of claim 5 wherein the hydrophobic siloxane prepolymer is a α,ω-bismethacryloxypropyl macromer and the silylated hydrophilic monomer is a polyalkylsilyl ether of a hydroxyalkyl(meth)acrylamide.
Claim 8
Dependent Claim
22 words
The process of claim 6 wherein the hydrophobic siloxane prepolymer is α,ω-bismethacryloxypropyl polydimethylsiloxane and the silylated hydrophilic monomer is 2-hydroxymethacrylamide trimethylsilyl ether.
Claim 9
Dependent Claim
12 words
A hydrogel comprising a hydrophobic siloxane prepolymer and a silylated hydrophilic monomer.
Claim 10
Dependent Claim
12 words
A hydrogel comprising a hydrophobic siloxane prepolymer and a silylated hydrophilic monomer.
Claim 11
Dependent Claim
11 words
The hydrogel of claim 8 further comprising a hydrophobic siloxane monomer.
Claim 12
Dependent Claim
57 words
The hydrogel of claim 9 wherein the hydrophobic siloxane monomer is of the formula: ##STR10## wherein R 19 and R 20 are each independently hydrogen or methyl, R 21 , R 22 , and R 23 are each independently a monovalent alkyl of 1 to 5 carbon atoms or aryl, j=1 to 10 and k=0 to 3.
Claim 13
Dependent Claim
14 words
The hydrogel of claim 10, wherein the hydrophobic siloxane monomer is 3-methacryloxypropyltris(methylsiloxy)silane or 3-methacryloxypropylbis(trimethylsiloxy)methylsilane.
Claim 14
Dependent Claim
78 words
The hydrogel of claim 8 or 10 wherein the hydrophobic siloxane prepolymer is of the formula: ##STR11## wherein R 1 is hydrogen or an alkyl of 1 to 5 carbon atoms, R 2 is an alkyl of 1 to 5 carbon atoms, n=1 to 12, and z=1 to 500 and the silylated hydrophilic monomer is of the formula: ##STR12## wherein R 24 is hydrogen or methyl, R 25 is hydrogen or methyl, and R 26 is a monoalkyl.
Claim 15
Dependent Claim
26 words
The hydrogel of claim 12 wherein the hydrophobic siloxane prepolymer is a α,ω-bismethacryloxypropyl macromer and the silylated hydrophilic monomer is a polyalkylsilyl ether of a hydroxyalkyl(meth)acrylamide.
Claim 16
Dependent Claim
22 words
The hydrogel of claim 13 wherein the hydrophobic siloxane prepolymer is α,ω-bismethacryloxypropyl polydimethylsiloxane and the silylated hydrophilic monomer is 2-hydroxymethacrylamide trimethylsilyl ether.
Claim 17
Dependent Claim
43 words
The hydrogel of claim 8 wherein the hydrophobic siloxane prepolymer is present in an amount of about 5 to about 70 weight percent and the amount of silylated hydrophilic monomer is present in an amount of about 2 to about 60 weight percent.
Claim 18
Dependent Claim
51 words
The hydrogel of claim 9 wherein the amount of siloxane prepolymer used is about 5 to about 70 weight percent, the amount of siloxane monomer used is from about 0 to about 70 weight percent, and the amount of silylated monomer used is from about 2 to about 60 weight percent.
Claim 19
Dependent Claim
16 words
The process of claim 1, wherein the polymerizing step a.) is carried out using ultraviolet light.
Claim 20
Dependent Claim
16 words
The process of claim 5, wherein the polymerizing step a.) is carried out using ultraviolet light.
Claim 21
Dependent Claim
16 words
The process of claim 6, wherein the polymerizing step a.) is carried out using ultraviolet light.
Claim 22
Dependent Claim
51 words
The hydrogel of claim 13 wherein the amount of siloxane prepolymer used is about 5 to about 70 weight percent, the amount of siloxane monomer used is from about 0 to about 70 weight percent, and the amount of silylated monomer used is from about 2 to about 60 weight percent.
Claim 23
Dependent Claim
51 words
The hydrogel of claim 14 wherein the amount of siloxane prepolymer used is about 5 to about 70 weight percent, the amount of siloxane monomer used is from about 0 to about 70 weight percent, and the amount of silylated monomer used is from about 2 to about 60 weight percent.
References Cited (Backward Citations)
US3935342A
Cited
US4182822A
Cited
US4136250A
Cited
US4261875A
Cited
US4260725A
Cited
EP0030807A1
Cited
US4332922A
Cited
US4419505A
Cited
US4486577A
Cited
US4481322A
Cited
US4575546A
Cited
US4649184A
Cited
JPS6370221A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-02-28 | 2003-08-30 | 2004-02-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-02-28 | 2007-08-30 | 2008-02-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-02-28 | 2011-08-30 | 2012-02-29 | $7700.00 | Window Closed / Lapsed |