US6030333A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable radiotherapy device
Assignee: RADIO MED Corp
•
Filing: 1997-10-24
•
Granted: 2000-02-29
•
Expires: 2017-10-24
Abstract
Abstract A general purpose implantable radiotherapy device for delivering a predetermined dose of radiation in a predetermined radiation pattern. The device includes a biocompatible template adapted for implantation at a treatment site in a patient, and one or more radiation sources which are incorporated directly into at least a portion of the template, preferably by ion implantation methods. The shape of the radiation pattern from the device is determined at least in part by the location and distribution of the radiation source or sources incorporated into the template, and not solely by the shape of the template. The device is suitable for a wide variety of radiotherapy applications.
Inventors
- 👤 Piran Sioshansi
- 👤 Raymond J. Bricault
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:00
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1007; A61N2005/1012; A61N2005/1019; A61N5/1027
Claims Analysis
Total Claims: 63
Claim 1
Independent Claim
123 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiation delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template.
Claim 2
Dependent Claim
123 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiation delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template.
Claim 3
Dependent Claim
48 words
A radiotherapy device according to claim 1, wherein said source of radiation comprises one or more radioisotopes which are incorporated directly into the material of said template by a technique selected from the group consisting of ion implantation, ion beam assisted deposition, sputtering, evaporation, laser ablation and plating.
Claim 4
Dependent Claim
21 words
A radiotherapy device according to claim 2, comprising at least two different radioisotopes incorporated into respective different portions of said template.
Claim 5
Dependent Claim
21 words
A radiotherapy device according to claim 2, comprising at least two different radioisotopes incorporated into a single portion of said template.
Claim 6
Dependent Claim
20 words
A radiotherapy device according to claim 2, comprising a single radioisotope incorporated into one or more portions of said template..
Claim 7
Dependent Claim
20 words
A radiotherapy device according to claim 5, wherein said single radioisotope is incorporated into substantially all portions of the template.
Claim 8
Dependent Claim
32 words
A radiotherapy device according to claim 2, further comprising a layer of a biocompatible encapsulating material deposited over the surface of said template after incorporation of said radiation source into said template.
Claim 9
Dependent Claim
37 words
A radiotherapy device according to claim 2, further comprising a non-radioactive therapeutic agent applied to at least a portion of said template for delivery of said therapeutic agent to said localized lesion or tumor with said radiation.
Claim 10
Dependent Claim
59 words
A radiotherapy device according to claim 1, wherein said template is in the form of a substantially elongated flexible filament which extends along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis, wherein the filament is bendable in situ to accommodate various lesion geometries.
Claim 11
Dependent Claim
15 words
A radiotherapy device according to claim 9, wherein said filament is made of a metal.
Claim 12
Dependent Claim
20 words
A radiotherapy device according to claim 9, wherein said filament has an aspect ratio of at least 3 to 1.
Claim 13
Dependent Claim
38 words
A radiotherapy device according to claim 1, wherein said template is made of a shape-memory material which can be formed into a desired configuration, prior to implantation or in situ, upon exposure to one or more environmental conditions.
Claim 14
Dependent Claim
17 words
A radiotherapy device according to claim 1, wherein said filament is formed into a substantially three-dimensional shape.
Claim 15
Dependent Claim
19 words
A radiotherapy device according to claim 1, wherein said device is adapted for substantially permanent implantation in a patient.
Claim 16
Dependent Claim
20 words
A radiotherapy device according to claim 1, wherein said device is adapted for temporary or removable implantation in a patient.
Claim 17
Dependent Claim
19 words
A radiotherapy device according to claim 1, wherein at least a portion of said template emits substantially no radiation.
Claim 18
Dependent Claim
28 words
A radiotherapy device according to claim 1, wherein said template further includes anchoring means for securing said template in tissue at or near said localized lesion or tumor.
Claim 19
Dependent Claim
159 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation at a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template, wherein said template is in the form of a substantially elongated flexible filament which extends along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis, and wherein said filament is made of a nonmetal.
Claim 20
Dependent Claim
159 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation at a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template, wherein said template is in the form of a substantially elongated flexible filament which extends along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis, and wherein said filament is made of a nonmetal.
Claim 21
Dependent Claim
15 words
A radiotherapy device according to claim 18, wherein said filament is made of a polymer.
Claim 22
Dependent Claim
92 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a biocompatible flexible filament adapted for implantation into or near a localized lesion or tumor in a patient, wherein the filament is bendable in situ to accommodate various lesion geometries; and b. at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive and define a unitary, structurally non-supporting radiotherapy delivery device.
Claim 23
Dependent Claim
92 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a biocompatible flexible filament adapted for implantation into or near a localized lesion or tumor in a patient, wherein the filament is bendable in situ to accommodate various lesion geometries; and b. at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive and define a unitary, structurally non-supporting radiotherapy delivery device.
Claim 24
Dependent Claim
48 words
A radiotherapy device according to claim 20, wherein said source of radiation comprises one or more radioisotopes which are incorporated directly into the material of said filament by a technique selected from the group consisting of ion implantation, ion beam assisted deposition, sputtering, evaporation, laser ablation and plating.
Claim 25
Dependent Claim
21 words
A radiotherapy device according to claim 21, comprising at least two different radioisotopes incorporated into respective different portions of said filament.
Claim 26
Dependent Claim
21 words
A radiotherapy device according to claim 21, comprising at least two different radioisotopes incorporated into a single portion of said filament.
Claim 27
Dependent Claim
20 words
A radiotherapy device according to claim 21, comprising a single radioisotope incorporated into one or more portions of said filament.
Claim 28
Dependent Claim
19 words
A radiotherapy device according to claim 24, wherein said single radioisotope is incorporated into substantially all of the filament.
Claim 29
Dependent Claim
47 words
A radiotherapy device according to claim 20, wherein said filament has an aspect ratio of at least 3 to 1 and extends along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis.
Claim 30
Dependent Claim
39 words
A radiotherapy device according to claim 20, wherein said filament is made of a flexible shape-memory material which can be formed into a desired configuration, prior to implantation or in situ, upon exposure to one or more environmental conditions.
Claim 31
Dependent Claim
15 words
A radiotherapy device according to claim 20, wherein said filament is made of a metal.
Claim 32
Dependent Claim
17 words
A radiotherapy device according to claim 20, wherein said filament is formed into a substantially three-dimensional shape.
Claim 33
Dependent Claim
32 words
A radiotherapy device according to claim 20, further comprising a layer of a biocompatible encapsulating material deposited over the surface of said filament after incorporation of said radiation source into said filament.
Claim 34
Dependent Claim
37 words
A radiotherapy device according to claim 30, further comprising a non-radioactive therapeutic agent applied to at least a portion of said filament for delivery of said therapeutic agent to said localized lesion or tumor with said radiation.
Claim 35
Dependent Claim
19 words
A radiotherapy device according to claim 20, wherein said device is adapted for substantially permanent implantation in a patient.
Claim 36
Dependent Claim
20 words
A radiotherapy device according to claim 20, wherein said device is adapted for temporary or removable implantation in a patient.
Claim 37
Dependent Claim
19 words
A radiotherapy device according to claim 20, wherein at least a portion of said filament emits substantially no radiation.
Claim 38
Dependent Claim
24 words
A radiotherapy device according to claim 20, wherein said filament further includes anchoring means for securing said filament in said localized lesion or tumor.
Claim 39
Dependent Claim
81 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a filament made of a biocompatible material and adapted for implantation at or near a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive, wherein said filament is made of a nonmetal.
Claim 40
Dependent Claim
81 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a filament made of a biocompatible material and adapted for implantation at or near a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive, wherein said filament is made of a nonmetal.
Claim 41
Dependent Claim
15 words
A radiotherapy device according to claim 36, wherein said filament is made of a polymer.
Claim 42
Dependent Claim
120 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a biocompatible, substantially solid template adapted for implantation into or near a localized lesion or tumor in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of said template.
Claim 43
Dependent Claim
120 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a biocompatible, substantially solid template adapted for implantation into or near a localized lesion or tumor in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of said template.
Claim 44
Dependent Claim
59 words
A radiotherapy device according to claim 38, wherein said template is in the form of a substantially elongated flexible filament which extends along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis, wherein the filament is bendable in situ to accommodate various lesion geometries.
Claim 45
Independent Claim
151 words
A method of treatment of a localized lesion with a predetermined dose of radiation, comprising the steps of: a. providing a template made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient, and at least one source of radiation adapted for incorporation into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, b. incorporating said radiation source into said template according to a predetermined distribution pattern, whereby the shape of the pattern of radiation provided by said device is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of said template; and c. implanting the device into or near a localized lesion or tumor in a patient.
Claim 46
Independent Claim
151 words
A method of treatment of a localized lesion with a predetermined dose of radiation, comprising the steps of: a. providing a template made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient, and at least one source of radiation adapted for incorporation into at least a portion of the template to render said portion of the template radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, b. incorporating said radiation source into said template according to a predetermined distribution pattern, whereby the shape of the pattern of radiation provided by said device is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of said template; and c. implanting the device into or near a localized lesion or tumor in a patient.
Claim 47
Dependent Claim
39 words
The method of claim 40, wherein said radiation source is incorporated directly into the material of said template by a technique selected from the group consisting of ion implantation, ion beam assisted deposition, sputtering, evaporation, laser ablation and plating.
Claim 48
Dependent Claim
20 words
The method of claim 41, wherein at least two different radioisotopes are incorporated into respective different portions of said template.
Claim 49
Dependent Claim
20 words
The method of claim 41, wherein at least two different radioisotopes are incorporated into a single portion of said template.
Claim 50
Dependent Claim
19 words
The method of claim 41, wherein a single radioisotope is incorporated into one or more portions of said template.
Claim 51
Dependent Claim
17 words
The method of claim 44, wherein said single radioisotope is incorporated into substantially all of the template.
Claim 52
Dependent Claim
33 words
The method of claim 41, comprising the further step of depositing a layer of a biocompatible encapsulating material over the surface of said template after incorporation of said radiation source into said template.
Claim 53
Dependent Claim
38 words
The method of claim 46, comprising the further step of applying a non-radioactive therapeutic agent to at least a portion of said template for delivery of said therapeutic agent to said localized lesion or tumor with said radiation.
Claim 54
Dependent Claim
36 words
The method of claim 40, wherein said template is made of a shape-memory material which can be formed into a desired configuration, prior to implantation or in situ, upon exposure to one or more environmental conditions.
Claim 55
Dependent Claim
53 words
The method of claim 40, wherein said template is formed into a substantially elongated flexible filament having an aspect ratio of at least 3 to 1 and extending along a principal axis, wherein radiation is emitted from said filament in a substantially elongated radiation pattern extending along and radially from said principal axis.
Claim 56
Dependent Claim
15 words
The method of claim 49, wherein said filament is formed into a substantially three-dimensional shape.
Claim 57
Dependent Claim
17 words
The method of claim 40, comprising the further step of permanently implanting the device in a patient.
Claim 58
Dependent Claim
17 words
The method of claim 40, comprising the further step of removably implanting the device in a patient.
Claim 59
Dependent Claim
149 words
A kit for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, the kit comprising: a. a general purpose radiotherapy device, including a flexible filament made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient, and at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said filament and is not determined solely by the shape of said filament, wherein the filament is bendable in situ to accommodate various lesion geometries; and b. a syringe for implanting the device into the patient.
Claim 60
Dependent Claim
149 words
A kit for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, the kit comprising: a. a general purpose radiotherapy device, including a flexible filament made of a biocompatible material and adapted for implantation into or near a localized lesion or tumor in a patient, and at least one source of radiation incorporated into at least a portion of the filament to render said portion of the filament radioactive and define a unitary, structurally non-supporting radiotherapy delivery device, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said filament and is not determined solely by the shape of said filament, wherein the filament is bendable in situ to accommodate various lesion geometries; and b. a syringe for implanting the device into the patient.
Claim 61
Dependent Claim
118 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation at a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template, wherein said template is made of a nonmetal.
Claim 62
Dependent Claim
118 words
A general purpose radiotherapy device for delivering to a treatment site in a patient a predetermined dose of radiation in a predetermined radiation pattern, said device comprising: a. a template made of a biocompatible material and adapted for implantation at a treatment site in a patient; and b. at least one source of radiation incorporated into at least a portion of the template to render said portion of the template radioactive, wherein the shape of said radiation pattern is determined at least in part by the distribution of said source of radiation on the exterior surfaces of said template and is not determined solely by the shape of the template, wherein said template is made of a nonmetal.
Claim 63
Dependent Claim
15 words
A radiotherapy device according to claim 54, wherein said template is made of a polymer.
References Cited (Backward Citations)
SU799189A1
Cited
US5059166A
Cited
US5176617A
Cited
US5342283A
Cited
US5725572A
Cited
US5607442A
Cited
US5871436A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-02-28 | 2003-08-30 | 2004-02-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-02-28 | 2007-08-30 | 2008-02-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-02-28 | 2011-08-30 | 2012-02-29 | $7700.00 | Window Closed / Lapsed |