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US6014584A
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Electroporation therapy apparatus
Assignee: OncoSec Medical Inc
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Filing: 1999-01-08
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Granted: 2000-01-11
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Expires: 2019-01-08
Abstract
Abstract A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
Inventors
- 👤 Gunter A. Hofmann
- 👤 Sukhendu B. Dev
- 👤 Steven C. Dimmer
- 👤 Jeffrey I. Levatter
- 👤 Gurvinder S. Nanda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:09
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/18; A61N1/32; A61N1/327; A61N1/05; A61N1/0502; A61P; A61P35/00; A61N1/325
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
102 words
An electroporation therapy apparatus, comprising: a. a source for generating voltage pulses; b. a connector for one of a plurality of electrode applicators having varying numbers of electrode needles, each electrode applicator including a type identification element, the type identification element representing at least the number of such electrode needles; c. a circuit for determining a determined number of electrode needles from the type identification element when one such electrode adapter is coupled to the connector; d. a circuit for setting the electroporation therapy apparatus to address the determined number of electrode needles and supply generated voltage pulses to addressed electrode needles.
Claim 2
Dependent Claim
102 words
An electroporation therapy apparatus, comprising: a. a source for generating voltage pulses; b. a connector for one of a plurality of electrode applicators having varying numbers of electrode needles, each electrode applicator including a type identification element, the type identification element representing at least the number of such electrode needles; c. a circuit for determining a determined number of electrode needles from the type identification element when one such electrode adapter is coupled to the connector; d. a circuit for setting the electroporation therapy apparatus to address the determined number of electrode needles and supply generated voltage pulses to addressed electrode needles.
Claim 3
Dependent Claim
20 words
The electroporation therapy apparatus of claim 1, further including a remote therapy activation device for controlling generation of voltage pulses.
Claim 4
Dependent Claim
18 words
The electroporation therapy apparatus of claim 2, wherein the remote therapy activation device comprises a foot pedal switch.
Claim 5
Dependent Claim
122 words
An electroporation therapy apparatus, comprising: (a) a source for generating voltage pulses having programmable electrical treatment parameters comprising at least one of: needle voltage setpoint, pulse length, or pulse shape; (b) a connector for one of a plurality of electrode applicators having electrode needles, each electrode applicator requiring selected electrical treatment parameters, each electrode applicator including a type identification element, the type identification element representing the specific electrical treatment parameters to be used with the electrode applicator; (c) a circuit for determining the specific electrical treatment parameters from the type identification element when an electrode adapter is coupled to the connector; (d) a circuit for programming the electrical treatment parameters for the electroporation therapy apparatus to the determined specific electrical treatment parameters.
Claim 6
Dependent Claim
122 words
An electroporation therapy apparatus, comprising: (a) a source for generating voltage pulses having programmable electrical treatment parameters comprising at least one of: needle voltage setpoint, pulse length, or pulse shape; (b) a connector for one of a plurality of electrode applicators having electrode needles, each electrode applicator requiring selected electrical treatment parameters, each electrode applicator including a type identification element, the type identification element representing the specific electrical treatment parameters to be used with the electrode applicator; (c) a circuit for determining the specific electrical treatment parameters from the type identification element when an electrode adapter is coupled to the connector; (d) a circuit for programming the electrical treatment parameters for the electroporation therapy apparatus to the determined specific electrical treatment parameters.
Claim 7
Dependent Claim
20 words
The electroporation therapy apparatus of claim 4, further including a remote therapy activation device for controlling generation of voltage pulses.
Claim 8
Dependent Claim
18 words
The electroporation therapy apparatus of claim 5, wherein the remote therapy activation device comprises a foot pedal switch.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-01-10 | 2003-07-12 | 2004-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-01-10 | 2007-07-12 | 2008-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-01-10 | 2011-07-12 | 2012-01-11 | $7700.00 | Window Closed / Lapsed |