Abstract The present invention relates to a bioadhesive that includes at least two constituents that are intended to be combined, for simultaneous, separate, or time-shifted use, i.e.: 1) a semi-liquid constituent (A) that includes, at a minimum, gelatin in an aqueous solution; and 2) A constituent (B), in gel or non-gel form, that includes, at a minimum, an aldehyde, with the exception of non-gel solutions consisting of formaldehyde, glutaraldehyde, or glyceraldehyde. The invention also relates to the use of succinic dialdehyde and of aldehyde solution sin gel form as hardeners in a bioadhesive, and further relates to a procedure for the preparation of the said bioadhesives and to a device for the application of the said bioadhesives.
A bioadhesive composition comprising: a first constituent including an aqueous solution of gelatin; and a second constituent maintained separately from the first constituent and including succinic dialdehyde present in an amount sufficient to promote cross-linking of the gelatin in the first constituent; wherein the first and second constituents may be combined and applied to tissue as an adhesive.
Claim 2
Dependent Claim
58 words
A bioadhesive composition comprising: a first constituent including an aqueous solution of gelatin; and a second constituent maintained separately from the first constituent and including succinic dialdehyde present in an amount sufficient to promote cross-linking of the gelatin in the first constituent; wherein the first and second constituents may be combined and applied to tissue as an adhesive.
Claim 3
Dependent Claim
14 words
A bioadhesive composition as in claim 1, wherein the second constituent is a gel.
Claim 4
Dependent Claim
35 words
A bioadhesive composition as in claim 2, wherein the second constituent comprises a gelling agent selected from the group consisting of agar, karaya gum, silica powder, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxylated cellulose, and carboxylated cellulose.
Claim 5
Dependent Claim
34 words
A bioadhesive composition as in any one of claims 1-3, wherein the aqueous solution of gelatin includes from 5 g to 20 g of gelatin for every 20 ml to 25 ml of water.
Claim 6
Dependent Claim
25 words
A bioadhesive composition as in any one of claims 1-3, wherein the second constituent comprises from 1% by weight to 40% by weight succinic dialdehyde.