US6007489A
Expired / Lapsed
US
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Method of and apparatus for histological human tissue characterization using ultrasound
Assignee: University of Maryland, Baltimore
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Filing: 1998-04-21
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Granted: 1999-12-28
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Expires: 2018-04-21
Abstract
Abstract A method and apparatus for determining important histological characteristics of tissue, including a determination of the tissue's health. Electrical pulses are converted into meaningful numerical representations through the use of Fourier Transforms. These numerical representations are then used to determine important histological characteristics of tissue. This novel invention does not require rectification and thus provides for detailed information from the ultrasonic scan.
Inventors
- 👤 William T. Yost
- 👤 John H. Cantrell
- 👤 George A. Tal Er
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:33
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4869; A61B5/41; A61B5/414; A61B5/416; A61B5/72; A61B5/7235; A61B5/7253; A61B5/7257; A61B8/00; A61B8/08; A61B8/0858
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
127 words
A method for detecting histological properties of human tissue, composed of an iterated stacking sequence of cellular and collagen containing structural components, using data obtained from ultrasonic ray inputs, comprising the steps of: emitting a high-frequency ultrasonic pulse into human tissue; collecting a subsequent sequence of reflected unrectified echoes from said tissue; converting said unrectified echoes into a sequence of unrectified electrical pulses; amplifying said sequence of unrectified electrical pulses; performing a Fourier transform upon said sequence of unrectified electrical pulses; selecting any part of said transform; plotting a display of said transform in terms of said part; evaluating said display to quantitatively determine a percentage of collagen in said collagen containing structural component, wherein said percentage can be used to assess the quality of said tissue.
Claim 2
Independent Claim
127 words
A method for detecting histological properties of human tissue, composed of an iterated stacking sequence of cellular and collagen containing structural components, using data obtained from ultrasonic ray inputs, comprising the steps of: emitting a high-frequency ultrasonic pulse into human tissue; collecting a subsequent sequence of reflected unrectified echoes from said tissue; converting said unrectified echoes into a sequence of unrectified electrical pulses; amplifying said sequence of unrectified electrical pulses; performing a Fourier transform upon said sequence of unrectified electrical pulses; selecting any part of said transform; plotting a display of said transform in terms of said part; evaluating said display to quantitatively determine a percentage of collagen in said collagen containing structural component, wherein said percentage can be used to assess the quality of said tissue.
Claim 3
Dependent Claim
22 words
The method as in claim 1 wherein said selecting comprises using a magnitude value of said transform to determine histological tissue characteristics.
Claim 4
Dependent Claim
22 words
The method as in claim 1 wherein said selecting comprises using a real value of said transform to determine histological tissue characteristics.
Claim 5
Dependent Claim
22 words
The method as in claim 1 wherein said selecting comprises using an imaginary value of said transform to determine histological tissue characteristics.
Claim 6
Dependent Claim
22 words
The method as in claim 1 wherein said selecting comprises using a phase value of said transform to determine histological tissue characteristics.
Claim 7
Dependent Claim
43 words
The method of claim 1 wherein said selecting step includes selecting any part of said transform to express a relationship among ultrasonic variables, and further comprising the step of detecting pressure ulcers in muscle tissue based on said expressed relationship among ultrasonic variables.
Claim 8
Dependent Claim
43 words
The method of claim 1 wherein said selecting step includes selecting any part of said transform to express a relationship among ultrasonic variables, and further comprising the step of detecting pressure ulcers in adipose tissue based on said expressed relationship among ultrasonic variables.
Claim 9
Dependent Claim
72 words
Apparatus for classifying histological characteristics of human tissue comprising: means for generating ultrasound pulses transducer means for applying said ultrasound pulses to said tissue and receiving returned ultrasound from said body means for converting said returned ultrasound pulses into a sequence of unrectified electrical pulses means for amplifying said pulses means for performing Fast Fourier Transforms on said amplified pulses means for determining said histological characteristics using any part of said transform.
Claim 10
Dependent Claim
72 words
Apparatus for classifying histological characteristics of human tissue comprising: means for generating ultrasound pulses transducer means for applying said ultrasound pulses to said tissue and receiving returned ultrasound from said body means for converting said returned ultrasound pulses into a sequence of unrectified electrical pulses means for amplifying said pulses means for performing Fast Fourier Transforms on said amplified pulses means for determining said histological characteristics using any part of said transform.
Claim 11
Dependent Claim
22 words
The apparatus of claim 8 wherein said means for determining histological characteristics is adapted to determine a magnitude value of said transform.
Claim 12
Dependent Claim
22 words
The apparatus of claim 8 wherein said means for determining histological characteristics is adapted to determine a real value of said transform.
Claim 13
Dependent Claim
22 words
The apparatus of claim 8 wherein said means for determining histological characteristics is adapted to determine an imaginary value of said transform.
Claim 14
Dependent Claim
22 words
The apparatus of claim 8 wherein said means for determining histological characteristics is adapted to determine a phase value of said transform.
Claim 15
Dependent Claim
23 words
The apparatus of claim 8 wherein said means for determining is adapted to determine the histological characteristic of pressure ulcers in muscle tissue.
Claim 16
Dependent Claim
23 words
The apparatus of claim 8 wherein said means for determining is adapted to determine the histological characteristic of pressure ulcers in adipose tissue.
References Cited (Backward Citations)
US5417215A
Cited
US5746209A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-12-27 | 2003-06-28 | 2003-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-12-27 | 2007-06-28 | 2007-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-12-27 | 2011-06-28 | 2011-12-28 | $7700.00 | Window Closed / Lapsed |