US5942414A
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Polynucleotides encoding human G-protein coupled receptor HIBEF51
Assignee: Human Genome Sciences Inc
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Filing: 1995-06-06
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Granted: 1999-08-24
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Expires: 2015-06-06
Abstract
Abstract Human G-protein Coupled receptor HIBEF51 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the human G-protein Coupled receptor HIBEF51 nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
Inventors
- 👤 Yi Li
- 👤 Mark D. Adams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
88 words
An isolated nucleic acid comprising a polynucleotide selected from the group consisting of: (a) a polynucleotide encoding amino acids 1-349 of SEQ ID NO:2; (b) a polynucleotide encoding amino acids 2-349 of SEQ ID NO:2; (c) a polynucleotide encoding the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 97182; (d) the complement of (a); (e) the complement of (b); (f) the complement of (c); and (g) a polynucleotide encoding the mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97182.
Claim 2
Dependent Claim
88 words
An isolated nucleic acid comprising a polynucleotide selected from the group consisting of: (a) a polynucleotide encoding amino acids 1-349 of SEQ ID NO:2; (b) a polynucleotide encoding amino acids 2-349 of SEQ ID NO:2; (c) a polynucleotide encoding the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 97182; (d) the complement of (a); (e) the complement of (b); (f) the complement of (c); and (g) a polynucleotide encoding the mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97182.
Claim 3
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (a).
Claim 4
Dependent Claim
18 words
The isolated nucleic acid molecule of claim 2, which comprises nucleotides 832 to 1878 of SEQ ID NO:1.
Claim 5
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (b).
Claim 6
Dependent Claim
18 words
The isolated nucleic acid molecule of claim 4, which comprises nucleotides 835 to 1878 of SEQ ID NO:1.
Claim 7
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (c).
Claim 8
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (d).
Claim 9
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (e).
Claim 10
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (f).
Claim 11
Dependent Claim
12 words
The isolated nucleic acid of claim 1, wherein said polynucleotide is (g).
Claim 12
Dependent Claim
11 words
The isolated nucleic acid molecule of claim 1 which is DNA.
Claim 13
Dependent Claim
11 words
The isolated nucleic acid molecule of claim 1 which is RNA.
Claim 14
Dependent Claim
17 words
The isolated nucleic acid molecule of claim 1, wherein said polynucleotide is fused to a heterologous polynucleotide.
Claim 15
Dependent Claim
16 words
The isolated nucleic acid molecule of claim 13, wherein said heterologous polynucleotide encodes a heterologous polypeptide.
Claim 16
Dependent Claim
11 words
A vector comprising the isolated nucleic acid molecule of claim 1.
Claim 17
Dependent Claim
15 words
A host cell genetically engineered to comprise the isolated nucleic acid molecule of claim 1.
Claim 18
Dependent Claim
20 words
A host sell genetically engineered to comprise the isolated nucleic acid molecule of claim 1 operatively associated with a promoter.
Claim 19
Dependent Claim
79 words
A vector comprising a polynucleotide selected from the group consisting of; (a) a polynucleotide encoding amino acids 1-349 of SEQ ID NO:2; (b) a polynucleotide encoding amino acids 2-349 of SEQ ID NO:2; (c) a polynucleotide encoding amino acids sequence encoded by the cDNA clone contained in ATCC Deposit No. 97182; and (d) a polynucleotide encoding the mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97182; wherein said polynucleotide is operatively associated with a promoter.
Claim 20
Dependent Claim
79 words
A vector comprising a polynucleotide selected from the group consisting of; (a) a polynucleotide encoding amino acids 1-349 of SEQ ID NO:2; (b) a polynucleotide encoding amino acids 2-349 of SEQ ID NO:2; (c) a polynucleotide encoding amino acids sequence encoded by the cDNA clone contained in ATCC Deposit No. 97182; and (d) a polynucleotide encoding the mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97182; wherein said polynucleotide is operatively associated with a promoter.
Claim 21
Dependent Claim
12 words
A host cell genetically engineered to comprise the vector of claim 18.
Claim 22
Dependent Claim
28 words
A method of producing a polypeptide comprising: (a) culturing the host cell of claim 19 under conditions such that said polypeptide is expressed; and (b) recovering said polypeptide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-08-23 | 2003-02-22 | 2003-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-08-23 | 2007-02-22 | 2007-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-08-23 | 2011-02-22 | 2011-08-24 | $7700.00 | Window Closed / Lapsed |