US5903149A
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Three-dimensional localized proton NMR spectroscopy using a hybrid of one-dimensional hadamard with two-dimensional chemical shift imaging
Assignee: University of Pennsylvania
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Filing: 1997-04-11
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Granted: 1999-05-11
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Expires: 2017-04-11
Abstract
Abstract Acquisition of three-dimensional image-guided localized proton spectroscopy (1H-MRS) in the human brain is achieved on a standard clinical imager with a hybrid of chemical shift imaging (CSI) and transverse Hadamard spectroscopic imaging (HSI). 16x16x4 arrays of 3.5 and 1 ml voxels were obtained in 27 minutes. The spatially-selective HSI 90 DEG pulses were incorporated naturally into a PRESS double spin-echo sequence to subdivide the VOI into 4 partitions along its short axis. Two-dimensional CSI is performed along the other long axes. Because the hybrid excites the spins in the entire VOI, a 2ROOT +E,rad N+EE signal-to-noise-ratio (SNR) gain per given examination time is realized compared to sequentially interleaving N two-dimensional slices. A twofold gain in sensitivity is demonstrated in the brain for N=4.
Inventors
- 👤 Oded Gonen
- 👤 Gadi Goelman
- 👤 John S. Leigh
- 👤 Lizann Bolinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:08
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/485; G01R33/446; G01R33/4818; G01R33/482; G01R33/4822
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
133 words
A nuclear magnetic resonance (NMR)-based method for obtaining proton ( 1 H) localized spectroscopic data indicative of the chemical composition of a human body organ, comprising the steps of: (A) subjecting the organ to electromagnetic energy sufficient to cause a response signal indicative of the chemical composition of said organ throughout a relatively thick cross-sectional slice comprising a prescribed number N of relatively thinner sub-slices; and (B) processing said response signal, using a Hadamard matrix comprising N rows in which a sum of all but one of said N rows is equal to zero, to obtain an array of proton ( 1 H) localized spectroscopic voxel data for each of said N sub-slices, wherein each said array is indicative of the chemical composition of said organ within a corresponding sub-slice of said organ.
Claim 2
Dependent Claim
133 words
A nuclear magnetic resonance (NMR)-based method for obtaining proton ( 1 H) localized spectroscopic data indicative of the chemical composition of a human body organ, comprising the steps of: (A) subjecting the organ to electromagnetic energy sufficient to cause a response signal indicative of the chemical composition of said organ throughout a relatively thick cross-sectional slice comprising a prescribed number N of relatively thinner sub-slices; and (B) processing said response signal, using a Hadamard matrix comprising N rows in which a sum of all but one of said N rows is equal to zero, to obtain an array of proton ( 1 H) localized spectroscopic voxel data for each of said N sub-slices, wherein each said array is indicative of the chemical composition of said organ within a corresponding sub-slice of said organ.
Claim 3
Dependent Claim
24 words
A method as recited in claim 1, wherein step (A) comprises exciting said relatively thick slice while simultaneously Hadamard encoding said relatively thinner subslices.
Claim 4
Dependent Claim
20 words
A method as recited in claim 1, wherein step (A) comprises the generation of a PRESS double spin-echo pulse sequence.
Claim 5
Dependent Claim
31 words
A method as recited in claim 1, wherein step (B) comprises the use of two-dimensional chemical shift imaging (CSI) to obtain localized two-dimensional arrays of voxel data for each said sub-slice.
Claim 6
Dependent Claim
207 words
A nuclear magnetic resonance (NMR)-based method for obtaining three-dimensional proton ( 1 H) localized spectroscopic data indicative of the chemical composition of a human body organ, comprising the steps of: (A) obtaining at least one N dimensional array of localized proton 1 H spectra of said human body organ by applying a chemical shift imaging sequence to a slice of said human body organ, thereby subjecting said human body organ to electromagnetic energy sufficient to cause a first response signal indicative of the chemical composition of said human body organ to be generated; (B) obtaining at least one M dimensional array of localized proton 1 H spectra of said human body organ by applying a Hadamard spectroscopy imaging sequence to said slice of said human body organ so as to cause a second response signal indicative of the chemical composition of said human body organ within respective sub-slices of said slice, where N≠0, M≠0, and N+M equals 3; and (C) generating a three-dimensional proton ( 1 H) spectroscopic image of said slice of said human body organ from said first and second response signals using a Hadamard matrix comprising N rows in which a sum of all but one of said N rows is equal to zero.
Claim 7
Dependent Claim
207 words
A nuclear magnetic resonance (NMR)-based method for obtaining three-dimensional proton ( 1 H) localized spectroscopic data indicative of the chemical composition of a human body organ, comprising the steps of: (A) obtaining at least one N dimensional array of localized proton 1 H spectra of said human body organ by applying a chemical shift imaging sequence to a slice of said human body organ, thereby subjecting said human body organ to electromagnetic energy sufficient to cause a first response signal indicative of the chemical composition of said human body organ to be generated; (B) obtaining at least one M dimensional array of localized proton 1 H spectra of said human body organ by applying a Hadamard spectroscopy imaging sequence to said slice of said human body organ so as to cause a second response signal indicative of the chemical composition of said human body organ within respective sub-slices of said slice, where N≠0, M≠0, and N+M equals 3; and (C) generating a three-dimensional proton ( 1 H) spectroscopic image of said slice of said human body organ from said first and second response signals using a Hadamard matrix comprising N rows in which a sum of all but one of said N rows is equal to zero.
Claim 8
Dependent Claim
42 words
A method as recited in claim 5, wherein said chemical shift imaging sequence is applied in a two-dimensional axial plane of said human body organ and said Hadamard spectroscopy imaging sequence is appled along a remaining axis of said human body organ.
Claim 9
Dependent Claim
37 words
A method as recited in claim 5, wherein said Hadamard spectroscopy imaging sequence is applied along a transverse axis of said human body organ, a longitudinal axis of said human body organ, or both of said axes.
References Cited (Backward Citations)
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