US5882945A
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Heterodimeric T lymphocyte receptor
Assignee: Massachusetts Institute of Technology
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Filing: 1994-06-21
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Granted: 1999-03-16
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Expires: 2014-06-21
Abstract
Abstract Disclosed is a heterodimeric T lymphocyte receptor subunit. The subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor subunit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes. T cell receptor subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
Inventors
- 👤 Haruo Saito
- 👤 David M. Kranz
- 👤 Herman N. Eisen
- 👤 Susumu Tonegawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:50
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/70503; C07K14/7051; A; A61; A61K; A61K39/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
76 words
A method for making an isolated antibody specific for the variable region of the alpha subunit of a mammalian T lymphocyte receptor, wherein the antibody is produced by the method comprising: expressing the variable region of the alpha subunit of the T lymphocyte receptor in a genetically engineered host selected from the group consisting of procaryotic and eucaryotic cells; immunizing with the variable region; and isolating antibody specific for the variable region of the alpha subunit.
Claim 2
Independent Claim
76 words
A method for making an isolated antibody specific for the variable region of the alpha subunit of a mammalian T lymphocyte receptor, wherein the antibody is produced by the method comprising: expressing the variable region of the alpha subunit of the T lymphocyte receptor in a genetically engineered host selected from the group consisting of procaryotic and eucaryotic cells; immunizing with the variable region; and isolating antibody specific for the variable region of the alpha subunit.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the variable region of the alpha subunit of the mammalian T lymphocyte receptor is an immunoglobulin-like domain.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the animal is immunized with the isolated variable region of the alpha subunit or a portion thereof.
Claim 5
Dependent Claim
35 words
The method of claim 1 wherein cells producing the antibody are isolated and used to make hybridomas expressing monoclonal antibodies specific for the variable region of the alpha subunit of a mammalian T lymphocyte receptor.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein the antibody is a human antibody.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-03-15 | 2002-09-14 | 2003-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-03-15 | 2006-09-14 | 2007-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-03-15 | 2010-09-14 | 2011-03-16 | $7700.00 | Window Closed / Lapsed |