US5863551A
Expired / Lapsed
US
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Implantable polymer hydrogel for therapeutic uses
Assignee: Organogel Canada Ltd
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Filing: 1996-10-16
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Granted: 1999-01-26
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Expires: 2016-10-16
Abstract
Abstract The hydrogel is a copolymer of an N-substituted methacrylamide or acrylamide, a cross-linking agent and a complex sugar or derivative, a tissue adhesion peptide or a polymer conjugate with antibodies, the polymer being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%. It can be used for tissue regeneration and for organ repair, for example, in the developing and adult nervous system.
Inventors
- 👤 Stephane Woerly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:56
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/3878; A61L27/14; A61L27/26; A61L27/50; A61L27/52; A61L31/00; A61L31/04; A61L31/041; A61L31/14; A61L31/145; A61P; A61P1/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
100 words
A polymer hydrogel for therapeutic use, comprising: a copolymer of (a) and N-substituted methacrylamide or acrylamide, (b) a cross-linking agent and (c) at least one type of copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, said polymer hydrogel being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-35 μm and a porous volume of pores measuring at least 10 μm equal to substantially 100% of the total fractional porosity of the hydrogel.
Claim 2
Dependent Claim
100 words
A polymer hydrogel for therapeutic use, comprising: a copolymer of (a) and N-substituted methacrylamide or acrylamide, (b) a cross-linking agent and (c) at least one type of copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, said polymer hydrogel being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-35 μm and a porous volume of pores measuring at least 10 μm equal to substantially 100% of the total fractional porosity of the hydrogel.
Claim 3
Dependent Claim
55 words
The polymer hydrogel of claim 1, wherein (a) said N-substituted methacrylamide or acrylamide is selected from the group consisting of N-monoalkyl and N,N-dialkylmethacrylamides and acrylamides, (b) said cross-linking agent is acrylamide or precursors thereof, and (c) said copolymerizable, biologically active molecule, which is tissue adhesive, is glucosamine, N-acetylglucosamine or an N-acetyl derivative of neuraminic acid.
Claim 4
Dependent Claim
14 words
The ploymer hydrogel of claim 2, wherein said alkyl group contains 1-2 carbon atoms.
Claim 5
Dependent Claim
15 words
The polymer hydrogel of claim 3, wherein said alkyl is a hydroxyalkyl or an aminoalkyl.
Claim 6
Dependent Claim
15 words
The polymer hydrogel of claim 1, wherein said equilibrium water content is at least 96%.
Claim 7
Dependent Claim
15 words
The polymer hydrogel of claim 1, wherein said hydrogel is covalently cross-linked and substantially non-transparent.
Claim 8
Dependent Claim
56 words
The polymer hydrogel of claim 6, wherein said hydrogel shows a clear phase separated structure formed of polymer particles of about 1-10 μm, thereby providing an area of relatively coarse porosity where the hydrogel is intended to interface with a host tissue and of relatively fine porosity where it is intended to interface with ingrowing tissue.
Claim 9
Dependent Claim
31 words
The polymer hydrogel of claim 1, which has a specific surface area of at least 100 m 2 /gram and a hyperporous character in the range of 20 to 30 μm.
Claim 10
Independent Claim
181 words
A method for preparing a heterogeneous, elastically deformable hydrogel for therapeutic use, which comprises: (a) dissolving a cross-linking agent in a solvent with a free radical polymerization initiator selected from the group consisting of azobisisobutyronitrile, a peroxide, ascorbic acid, a peroxysulfate or a substituted azo compound, said initiator being present in an amount ranging from 0.01-2% by weight with respect to the polymer hydrogel which is formed, to form a solution; (b) adding an N-substituted methacrylamide or acrylamide to the solution obtained in (a) to form a mixture, (c) adding a solution of a copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, to said solution; and (d) polymerizing the components (a) to (c), thereby obtaining a polymer hydrogel which is heterogeneous, elastically deformable and has an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-25 μm and a porous volume of pores measuring at least 10 μm equal to substantially 100% of the total fractional porosity of the hydrogel.
Claim 11
Independent Claim
181 words
A method for preparing a heterogeneous, elastically deformable hydrogel for therapeutic use, which comprises: (a) dissolving a cross-linking agent in a solvent with a free radical polymerization initiator selected from the group consisting of azobisisobutyronitrile, a peroxide, ascorbic acid, a peroxysulfate or a substituted azo compound, said initiator being present in an amount ranging from 0.01-2% by weight with respect to the polymer hydrogel which is formed, to form a solution; (b) adding an N-substituted methacrylamide or acrylamide to the solution obtained in (a) to form a mixture, (c) adding a solution of a copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, to said solution; and (d) polymerizing the components (a) to (c), thereby obtaining a polymer hydrogel which is heterogeneous, elastically deformable and has an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-25 μm and a porous volume of pores measuring at least 10 μm equal to substantially 100% of the total fractional porosity of the hydrogel.
Claim 12
Dependent Claim
47 words
The method of claim 9, which comprises: dissolving azobisisobutyronitrile and methylene bisacrylamide in said solvent, thereby forming a solution; mixing said solution with N-(2-hydroxypropyl)methacrylamide; adding glucosamine or N-actylglucosamine or N-acetylneuraminic acid thereto; polymerizing the monomer mixture; and removing low molecular weight residual products and initiator traces therefrom.
Claim 13
Dependent Claim
17 words
The method of claim 9, wherein said cross-linking agent is acrylamide, precursors thereof or diving cross-linking agents.
Claim 14
Dependent Claim
22 words
The method of claim 9, wherein said complex sugar is glucosamine, N-acetylglucosamine, N-acetyl derivatives of neuraminic acid, polysialic acid or galactosamine derivatives.
Claim 15
Dependent Claim
20 words
The method of claim 9, wherein said solution of polymerizable material comprises at least one type of tissue adhesion peptide.
Claim 16
Dependent Claim
22 words
The method of claim 9 wherein the copolymerization reaction is conducted at a temperature ranging from 40°-60° C. for about 12 hours.
References Cited (Backward Citations)
US4902295A
Cited
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