US5808007A
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Growth differentiation factor-3
Assignee: Johns Hopkins University
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Filing: 1994-01-12
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Granted: 1998-09-15
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Expires: 2014-01-12
Abstract
Abstract Growth Differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
Inventors
- 👤 Se-Jin Lee
- 👤 Alexandra C. McPherron
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:15
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/0004; A61P; A61P35/00; A61P35/02; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
18 words
Substantially pure growth differentiation factor-3 (GDF-3) polypeptide as set forth in SEQ ID NO:6 or SEQ ID NO:29.
Claim 2
Dependent Claim
18 words
Substantially pure growth differentiation factor-3 (GDF-3) polypeptide as set forth in SEQ ID NO:6 or SEQ ID NO:29.
Claim 3
Dependent Claim
86 words
An isolated polynucleotide selected from the group consisting of: a) SEQ ID NO:5; b) SEQ ID NO:28; c) a nucleotide sequence which encodes a polypeptide as set forth in SEQ ID NO:6 or SEQ ID NO:29; d) fragments of a), b), or c) that are at least 15 bases in length and that hybridize to a polynucleotide encoding the protein of SEQ ID NO:6 or SEQ ID NO:29; e) degenerate nucleotide sequences encoding the amino acid sequences as encoded by any of a), b), or c).
Claim 4
Dependent Claim
86 words
An isolated polynucleotide selected from the group consisting of: a) SEQ ID NO:5; b) SEQ ID NO:28; c) a nucleotide sequence which encodes a polypeptide as set forth in SEQ ID NO:6 or SEQ ID NO:29; d) fragments of a), b), or c) that are at least 15 bases in length and that hybridize to a polynucleotide encoding the protein of SEQ ID NO:6 or SEQ ID NO:29; e) degenerate nucleotide sequences encoding the amino acid sequences as encoded by any of a), b), or c).
Claim 5
Dependent Claim
14 words
The polynucleotide of claim 2, wherein the polynucleotide is isolated from a mammalian cell.
Claim 6
Dependent Claim
21 words
The polynucleotide of claim 3, wherein the mammalian cell is selected from the group consisting of mouse, rat, and human cell.
Claim 7
Dependent Claim
9 words
An expression vector including the polynucleotide of claim 2.
Claim 8
Dependent Claim
11 words
The vector of claim 5, wherein the vector is a plasmid.
Claim 9
Dependent Claim
13 words
The vector of claim 5, wherein the vector is derived from a virus.
Claim 10
Dependent Claim
11 words
A host cell stably transformed with the vector of claim 5.
Claim 11
Dependent Claim
11 words
The host cell of claim 8, wherein the cell is prokaryotic.
Claim 12
Dependent Claim
11 words
The host cell of claim 8, wherein the cell is eukaryotic.
Claim 13
Dependent Claim
11 words
An isolated polynucleotide which encodes a polypeptide of SEQ ID NO:6.
Claim 14
Dependent Claim
11 words
An isolated polynucleotide which encodes a polypeptide of SEQ ID NO:6.
Claim 15
Dependent Claim
11 words
An isolated polynucleotide which encodes a polypeptide of SEQ ID NO:29.
Claim 16
Dependent Claim
11 words
An isolated polynucleotide which encodes a polypeptide of SEQ ID NO:29.
Claim 17
Dependent Claim
16 words
The polynucleotide of SEQ ID NO:5 or SEQ ID NO:28 wherein T can also be U.
Claim 18
Dependent Claim
16 words
The polynucleotide of SEQ ID NO:5 or SEQ ID NO:28 wherein T can also be U.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-09-14 | 2002-03-16 | 2002-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-09-14 | 2006-03-16 | 2006-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-09-14 | 2010-03-16 | 2010-09-15 | $7700.00 | Window Closed / Lapsed |