US5807318A
Expired / Lapsed
US
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Method of perfusing the coronary vasculature
Assignee: Edwards Lifesciences LLC
•
Filing: 1996-03-12
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Granted: 1998-09-15
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Expires: 2016-03-12
Abstract
Abstract A catheter system is provided for accessing the coronary ostia transluminally from a peripheral arterial access site, such as the femoral artery, and for inducing cardioplegic arrest by direct infusion of cardioplegic solution into the coronary arteries. In a first embodiment, the catheter system is in the form of a single perfusion catheter with multiple distal branches for engaging the coronary ostia. In a second embodiment, multiple perfusion catheters are delivered to the coronary ostia through a single arterial cannula. In a third embodiment, multiple perfusion catheters are delivered to the coronary ostia through a single guiding catheter. In a fourth embodiment, multiple catheters are delivered to the coronary ostia through a single guiding catheter which has distal exit ports that are arranged to direct the perfusion catheters into the coronary ostia. In each embodiment, the catheters are equipped with an occlusion means at the distal end of the catheter for closing the coronary ostia and isolating the coronary arteries from the systemic blood flow. The occlusion means can take the form of an inflatable occlusion balloon cuff, a tapered occlusion device or an O-ring encircling the distal end of the catheter. An optional ventricular venting catheter can be included in the system for venting blood and fluids from the left ventricle of the heart. The catheter system is combined with a femoral-to-femoral cardiopulmonary bypass system to provide a system for cardioplegic arrest and total cardiopulmonary support during minimally invasive cardiac surgical procedures.
Inventors
- 👤 Frederick G. St. Goar
- 👤 William S. Peters
- 👤 Philip C. Evard
- 👤 Stephen W. Boyd
- 👤 Craig L. Adams
- 👤 Richard L. Mueller, Jr.
- 👤 John H. Stevens
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:54
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0067; A61M25/0068; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2427; A61M1/00; A61M1/36; A61M1/3613; A61M1/3621; A61M1/3653; A61M1/3659; A61M25/0021; A61M25/0041; A61M25/01; A61M25/06; A61M25/0662; A61M25/10; A61B; A61B17/00; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B18/00; A61B2018/00053; A61B2018/00214; A61B2018/0022; A61B2018/00232; A61B2018/0025; A61B2018/00261; A61M25/0023; A61M25/0026; A61M25/003; A61M2025/0031; A61M2025/0034; A61M2025/0036; A61M2025/004; A61M25/0043; A61M2025/0057; A61M25/0074; A61M25/0075; A61M2025/0076; A61M2025/0078; A61M25/0082; A61M25/0084; A61M2025/0087; A61M25/02; A61M2025/028; A61M2025/1043; A61M2025/1047; A61M2025/1077; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/047; A61M2205/00; A61M2205/11; A61M2205/36; A61M2205/366; A61M2210/00; A61M2210/12; A61M2210/125; A61M25/005; A61M25/008; A61M25/0105; A61M25/0125; A61M25/1002
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
95 words
A method of inducing cardioplegic arrest in a heart of a patient, the heart having a coronary vasculature, comprising the steps of: a) introducing at least one distal end of at least one perfusion catheter into a peripheral artery of said patient; b) advancing said distal end of said perfusion catheter from said peripheral artery into at least one coronary ostium of a coronary artery communicating with said coronary vasculature of said patient; c) occluding said coronary ostium of the coronary artery with an occlusion device mounted to said perfusion catheter; d) arresting the heart.
Claim 2
Independent Claim
95 words
A method of inducing cardioplegic arrest in a heart of a patient, the heart having a coronary vasculature, comprising the steps of: a) introducing at least one distal end of at least one perfusion catheter into a peripheral artery of said patient; b) advancing said distal end of said perfusion catheter from said peripheral artery into at least one coronary ostium of a coronary artery communicating with said coronary vasculature of said patient; c) occluding said coronary ostium of the coronary artery with an occlusion device mounted to said perfusion catheter; d) arresting the heart.
Claim 3
Dependent Claim
32 words
The method of claim 1, wherein step d) comprises the substep of infusing a cardioplegic agent through a lumen of said perfusion catheter into said coronary vasculature downstream of said occlusion device.
Claim 4
Dependent Claim
35 words
The method of claim 2 wherein said cardioplegic agent is infused through said lumen of said perfusion catheter at a rate of at least approximately 100 ml/min at a pump pressure not exceeding 350 mmHg.
Claim 5
Dependent Claim
55 words
The method of claim 1, wherein step d) comprises the substep of infusing a mixture of oxygenated blood and a cardioplegic agent through a lumen of said perfusion catheter into said coronary vasculature downstream of said occlusion device at a rate of at least approximately 100 ml/min at a pump pressure not exceeding 350 mmHg.
Claim 6
Dependent Claim
37 words
The method of claim 1, further comprising the step of: e) isolating said coronary vasculature from systemic circulation of said patient by continuing to occlude said coronary ostium with said occlusion device while the heart is arrested.
Claim 7
Dependent Claim
21 words
The method of claim 5, further comprising the step of: f) maintaining systemic circulation of said patient with peripheral cardiopulmonary bypass.
Claim 8
Dependent Claim
60 words
The method of claim 6, wherein step f) comprises: positioning an arterial cannula in a peripheral artery of said patient; positioning a venous cannula in a peripheral vein of said patient; withdrawing venous blood from said patient through a blood flow lumen in said venous cannula; infusing oxygenated blood into said patient through an infusion lumen in said arterial cannula.
Claim 9
Dependent Claim
40 words
The method of claim 1, further comprising the steps of: g) introducing a venting lumen through an aortic valve of said heart of said patient; h) venting a left ventricle of said heart by withdrawing fluid through the venting lumen.
Claim 10
Dependent Claim
103 words
The method of claim 1, wherein step a) comprises introducing a single perfusion catheter having at least two distal ends into said peripheral artery of said patient; step b) comprises advancing said at least two distal ends into at least two coronary ostia; step c) comprises occluding each of said at least two coronary ostia with an occlusion device proximate each of said at least two distal ends, respectively; and step d) comprises infusing a cardioplegic agent through at least one lumen communicating with said at least two distal ends of said perfusion catheter into said coronary vasculature downstream of said occlusion devices.
Claim 11
Dependent Claim
54 words
The method of claim 9, further comprising the steps of: g) introducing a third distal end of said perfusion catheter through an aortic valve of said heart of said patient; h) venting a left ventricle of said heart by withdrawing fluid through a venting lumen communicating with said third distal end of said catheter.
Claim 12
Dependent Claim
114 words
The method of claim 1, wherein step a) comprises introducing the distal ends of at least two perfusion catheters into said peripheral artery of said patient; step b) comprises advancing said distal ends of said at least two perfusion catheters into at least two coronary ostia; step c) comprises occluding each of said at least two coronary ostia with an occlusion device proximate each of said distal ends of said at least two perfusion catheters, respectively; and step d) comprises infusing a cardioplegic agent through at least two lumina communicating with said distal ends of said at least two perfusion catheters, respectively, into said coronary vasculature downstream of said at least two occlusion devices.
Claim 13
Dependent Claim
53 words
The method of claim 11, further comprising the steps of: g) introducing a distal end of a venting catheter through an aortic valve of said heart of said patient; h) venting a left ventricle of said heart by withdrawing fluid through a venting lumen communicating with said distal end of said venting catheter.
Claim 14
Dependent Claim
19 words
The method of claim 1, wherein step c) comprises inflating an inflatable occlusion device to occlude said coronary ostium.
Claim 15
Dependent Claim
55 words
The method of claim 1, wherein step a) comprises the substeps of: introducing a guide catheter having at least one internal lumen into said peripheral artery of said patient; and introducing said at least one distal end of said at least one perfusion catheter through said at least one internal lumen of said guide catheter.
Claim 16
Dependent Claim
52 words
The method of claim 11, wherein step a) comprises the substeps of: introducing a guide catheter having at least one internal lumen into said peripheral artery of said patient; and introducing the distal ends of said at least two perfusion catheters through said at least one internal lumen of said guide catheter.
Claim 17
Dependent Claim
67 words
The method of claim 11, wherein step a) comprises the substeps of: introducing a guide catheter having at least two internal lumina into said peripheral artery of said patient; and introducing the distal end of a first perfusion catheter through a first internal lumen in said guide catheter, and introducing the distal end of a second perfusion catheter through a second internal lumen in said guide catheter.
Claim 18
Independent Claim
24 words
The method of claim l further comprising the step of: i) performing coronary artery bypass graft surgery on the arrested heart of the patient.
Claim 19
Dependent Claim
60 words
The method of claim 1, further comprising the step of: infusing oxygenated blood into the patient through an arterial cannula; and the inserting step is carried out by passing the at least one perfusion catheter through the arterial cannula; the advancing step being carried out with the at least one perfusion catheter being slidably moved relative to the arterial cannula.
Claim 20
Independent Claim
116 words
A method of cooling myocardial tissue in a heart of a patient, the heart having a coronary vasculature, comprising the steps of: a) introducing a distal end of at least one catheter into a peripheral artery of said patient; b) advancing said distal end of said at least one catheter from said peripheral artery into at least one coronary ostium of a coronary artery communicating with said coronary vasculature of said patient; c) occluding said coronary ostium of the coronary artery with an occlusion device mounted to the at least one catheter; d) infusing a cold fluid into said coronary vasculature through a first lumen; e) withdrawing fluid from said coronary vasculature through a second lumen.
Claim 21
Independent Claim
116 words
A method of cooling myocardial tissue in a heart of a patient, the heart having a coronary vasculature, comprising the steps of: a) introducing a distal end of at least one catheter into a peripheral artery of said patient; b) advancing said distal end of said at least one catheter from said peripheral artery into at least one coronary ostium of a coronary artery communicating with said coronary vasculature of said patient; c) occluding said coronary ostium of the coronary artery with an occlusion device mounted to the at least one catheter; d) infusing a cold fluid into said coronary vasculature through a first lumen; e) withdrawing fluid from said coronary vasculature through a second lumen.
Claim 22
Dependent Claim
66 words
The method of claim 1, wherein step d) comprises infusing a cold fluid containing a cardioplegic agent into said coronary vasculature through said first lumen in a greater quantity than the quantity of fluid withdrawn from said coronary vasculature through said second lumen in step e), whereby at least some of said cold fluid containing a cardioplegic agent is forced to flow through said coronary vasculature.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-09-14 | 2002-03-16 | 2002-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-09-14 | 2006-03-16 | 2006-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-09-14 | 2010-03-16 | 2010-09-15 | $7700.00 | Window Closed / Lapsed |