US5785658A
Expired / Lapsed
US
⏱️ 0.0 years remaining
In vivo tissue analysis methods and apparatus
Assignee: JB IP Acquisition LLC
•
Filing: 1995-06-07
•
Granted: 1998-07-28
•
Expires: 2015-06-07
Abstract
Abstract A tool for nondestructive interrogation of the tissue including a light source emitter and detector which may be mounted directly on the surgical tool in a tissue contacting surface for interrogation or mounted remotely and guided to the surgical field with fiber optic cables. The light source may be broadband and wavelength differentiation can be accomplished at the detector via filters or gratings, or using time, frequency, or space resolved methods. Alternatively, n discrete monochromatic light sources may be provided which are subsequently multiplexed into a single detector by time or by frequency multiplexing. The optical sensing elements can be built into a surgical tool end effector tip such as a tissue grasping tool which has cooperating jaws (bivalve or multi-element). In the preferred embodiment the light source (or the fiber optic guide) is mounted on one jaw and the detector (or fiber optic guide) is mounted in the opposing jaw so that the light emitter and detector are facing one another either directly (i.e., on the same optical axis when the tool is closed) or acutely (i.e., with intersecting optical axes so that the light emitted is detected). In this case, the sensor is working in a transmission modality. Arrangements with the optical components mounted on the same member of a single member or a multi member structure, operating in a reflective modality, are disclosed.
Inventors
- 👤 David A. Benaron
- 👤 Daniel S. Goldberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:29
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/34; A61B17/3417; A61B17/3494; A61B18/00; A61B5/00; A61B5/0059; A61B5/0082; A61B5/0084; A61B5/0086; A61B5/68; A61B5/6846; A61B5/6847; A61B5/6848; G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/4795; A61B17/068; A61B17/28; A61B17/29; A61B17/3474; A61B18/04; A61B18/12; A61B18/14; A61B2017/00017; A61B2017/00022; A61B2017/00057; A61B2017/00061; A61B2017/00115; A61B2017/00119; A61B2017/00123; A61B17/00491; A61B2017/00504; A61B2017/00508; A61B2017/00535; A61B2017/00557; A61B90/00; A61B90/36; A61B90/361; A61B2090/3614; A61B2560/00; A61B2560/02; A61B2560/0266; A61B2560/0276; A61B2562/00; A61B2562/02; A61B2562/0233; A61B2562/0242; A61B2562/08; A61B5/0075
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
150 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type.
Claim 2
Dependent Claim
150 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type.
Claim 3
Dependent Claim
29 words
The analyzer of claim 1 wherein said library of spectra records includes a set of spectra records corresponding to distinct types of tissue classes, including ureter, liver, and kidney.
Claim 4
Dependent Claim
32 words
The analyzer system of claim 1 wherein said library of spectra records includes a set of spectra records corresponding to different pathological states of a selected tissue class including normal and cancerous.
Claim 5
Dependent Claim
77 words
The analyzer of claim 1 further comprising a light source controller operatively connected to said source of electromagnetic radiation to control an amount of electromagnetic radiation emitted, wherein the signal processor further comprises a second output signal in response to an identification of said detection spectra that is a control signal, wherein said light source controller is responsive to said control signal to cause the source of electromagnetic radiation to emit said controlled amount of electromagnetic radiation.
Claim 6
Dependent Claim
28 words
The analyzer of claim 1 wherein the spectrometer further comprises an optical demultiplexor separating the detected radiation into at least two distinct wavelengths corresponding to the detection spectra.
Claim 7
Dependent Claim
19 words
The analyzer of claim 5 wherein the optical demultiplexor is one of a synchronous demultiplexor and a frequency demultiplexor.
Claim 8
Dependent Claim
37 words
The analyzer of claim 1 wherein the signal processor further comprises an interlock output signal in response to the identified tissue type being one of a subset of the plurality of known tissue types in said library.
Claim 9
Dependent Claim
23 words
The analyzer of claim 1 wherein said library comprises a plurality of predetermined spectra records corresponding to a plurality of known tissue types.
Claim 10
Dependent Claim
58 words
The analyzer of claim 8 wherein said signal processor further comprises a memory device containing said library and is operable to modify said library by data input from at least one of a CD-ROM, a magnetic tape, an IC ROM, a modem, a PCMCIA disk, a PCMCIA memory, a direct user input, and a previously detected detection spectra.
Claim 11
Dependent Claim
36 words
The analyzer of claim 8 wherein said signal processor further comprises means for improving an accuracy level of the signal processor in response to an operation of said signal processor and a previously detected detection spectra.
Claim 12
Dependent Claim
23 words
The analyzer of claim 1 further comprising a determination memory wherein at least some data is stored in response to each tissue characterization.
Claim 13
Dependent Claim
27 words
The analyzer of claim 1 wherein said signal processor further comprises means for providing said first output signal as output signals corresponding to multiple tissue types identified.
Claim 14
Dependent Claim
49 words
The analyzer of claim 1 wherein said spectrometer further comprises means for detecting a feature of said electromagnetic radiation having passed through the tissue selected from at least one of absorbance, scattering, fluorescence, optical rotation, elastic scattering, temperature, time resolved optical data, frequency-resolved optical data, reflectance, opacity and turbidity.
Claim 15
Dependent Claim
24 words
The analyzer of claim 1 wherein said spectrometer further comprises means for separating an absorbance effect and a scattering effect of said electromagnetic radiation.
Claim 16
Dependent Claim
16 words
The spectrometer of claim 14 wherein said separating means is operable to perform a time-resolved analysis.
Claim 17
Dependent Claim
16 words
The spectrometer of claim 14 wherein said separating means is operable to perform a frequency-resolved analysis.
Claim 18
Dependent Claim
15 words
The spectrometer of claim 14 wherein said separating means is operable to perform multifiber spatial-analysis.
Claim 19
Independent Claim
107 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue.
Claim 20
Independent Claim
107 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue.
Claim 21
Dependent Claim
30 words
The method of claim 18 wherein said providing the library further comprises providing a set of spectra records corresponding to distinct types of tissue classes, including ureter, liver, and kidney.
Claim 22
Dependent Claim
31 words
The method of claim 18 wherein providing the library further comprises providing a set of spectral records corresponding to different pathological states of a selected tissue class including normal and cancerous.
Claim 23
Dependent Claim
32 words
The method of claim 18 wherein detecting the detected radiation further comprises providing an optical demultiplexor and separating the detected radiation into at least two distinct wavelengths corresponding to the detection spectra.
Claim 24
Dependent Claim
35 words
The method of claim 18 further comprising generating an interlock output signal in response to the identified tissue type being one of a predetermined subset of the plurality of known tissue types in said library.
Claim 25
Dependent Claim
44 words
The method of claim 18 further comprising updating said library with a set from at least one of a CD-ROM, a magnetic tape, an IC ROM, a modem, a PCMCIA disk, a PCMCIA memory, a direct user input, and a previously detected detection spectra.
Claim 26
Dependent Claim
30 words
The method of claim 18 further comprising improving an accuracy level of the identifying step in response to a prior processing and relating of a detection spectra and said library.
Claim 27
Dependent Claim
45 words
The method of claim 18 wherein detecting the electromagnetic radiation further comprises detecting a feature of said electromagnetic radiation selected from at least one of absorbance, scattering, fluorescence, optical rotation, elastic scattering, temperature, time resolved optical data, frequency resolved optical data, reflectance, opacity and turbidity.
Claim 28
Dependent Claim
38 words
The method of claim 18 wherein detecting the electromagnetic radiation further comprises separating an absorbance effect and a scattering effect of said electromagnetic radiation and performing one of a time-resolved analysis, a frequency-resolved analysis, and a spatial-resolved analysis.
Claim 29
Dependent Claim
83 words
The method of claim 18 further comprising performing a surgical intervention wherein said intervention further comprises coupling an optical fiber to a surgical tool end effector for performing said intervention, and detecting the detection spectra using said optical fiber at said end effector, determining whether the characterized tissue at said end effector is one of a subset of the plurality of known tissue types, and indicating whether or not to perform the surgical intervention on said characterized tissue in response to said determination.
Claim 30
Dependent Claim
59 words
The method of claim 27 wherein performing the surgical intervention further comprises not severing the characterized tissue in response to the characterized tissue being one of tissue containing a flow of blood, a nerve, a bile duct, a lymph duct, and a ureter, wherein the indicating step further comprises generating an alarm indicative of not severing the characterized tissue.
Claim 31
Dependent Claim
19 words
The method of claim 28 wherein generating the alarm further comprises inhibiting the end effector from severing said tissue.
Claim 32
Dependent Claim
204 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said library includes a set of spectra records corresponding to a sequence of effects of a surgical intervention on a blood carrying tissue including normal blood flow, coagulated blood and over-coagulated blood in said tissue, wherein the blood carrying tissue contains at least one of an artery, a vein, and a capillary bed, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type.
Claim 33
Dependent Claim
204 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said library includes a set of spectra records corresponding to a sequence of effects of a surgical intervention on a blood carrying tissue including normal blood flow, coagulated blood and over-coagulated blood in said tissue, wherein the blood carrying tissue contains at least one of an artery, a vein, and a capillary bed, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type.
Claim 34
Dependent Claim
32 words
The analyzer of claim 30 wherein said signal processor further comprises means for averaging multiple ones of said detection spectra over time and improving an accuracy level of the first output signal.
Claim 35
Dependent Claim
28 words
The analyzer of claim 30 wherein said signal processor further comprises means for providing a second output signal corresponding to a probabilistic strength of the first output signal.
Claim 36
Dependent Claim
32 words
The analyzer of claim 32 wherein said signal processor further comprises means for averaging multiple ones of said detection spectra over time and improving an accuracy level of the first output signal.
Claim 37
Dependent Claim
177 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type, wherein said signal processor further comprises means for averaging multiple ones of said detection spectra over time and improving an accuracy level of the first output signal.
Claim 38
Dependent Claim
177 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type, wherein said signal processor further comprises means for averaging multiple ones of said detection spectra over time and improving an accuracy level of the first output signal.
Claim 39
Dependent Claim
28 words
The analyzer of claim 34 wherein said signal processor further comprises means for providing a second output signal corresponding to a probabilistic strength of the first output signal.
Claim 40
Dependent Claim
176 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said amount of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type, wherein said signal processor further comprises means for providing a second output signal corresponding to a probabilistic strength of the first output signal.
Claim 41
Dependent Claim
176 words
An analyzer for characterizing tissue in vivo comprising: a source of electromagnetic radiation to emit electromagnetic radiation into a tissue to be characterized; a spectrometer adapted to be optically coupled to said tissue to detect electromagnetic radiation, having a detection spectra output corresponding to at least one preselected wavelength of the detected radiation in response to at least a portion of said amount of said electromagnetic radiation having passed through the tissue to be characterized; and a signal processor connected to the spectrometer output, having a library of known spectra records corresponding to a plurality of known tissue types, wherein said processor is operable to relate said detection spectra to said library to identify the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, and generate a first output signal characterizing the identified tissue type, wherein said signal processor further comprises means for providing a second output signal corresponding to a probabilistic strength of the first output signal.
Claim 42
Independent Claim
158 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types including a set of spectra records corresponding to a sequence of effects of a surgical intervention on a blood carrying tissue including normal blood flow, coagulated blood and over-coagulated blood in said tissue, wherein the blood carrying tissue contains at least one of an artery, a vein, and a capillary bed; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue.
Claim 43
Independent Claim
158 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types including a set of spectra records corresponding to a sequence of effects of a surgical intervention on a blood carrying tissue including normal blood flow, coagulated blood and over-coagulated blood in said tissue, wherein the blood carrying tissue contains at least one of an artery, a vein, and a capillary bed; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue.
Claim 44
Dependent Claim
30 words
The method of claim 37 wherein processing the detection spectrum further comprises averaging multiple ones of said detection spectra over time, thereby to improve an accuracy level of tissue characterization.
Claim 45
Dependent Claim
24 words
The method of claim 37 wherein processing said detection spectra further comprises providing a signal corresponding to a probabilistic strength of the tissue characterization.
Claim 46
Dependent Claim
32 words
The method of claim 39 wherein performing the processing the detection spectrum further comprises averaging multiple ones of said detection spectra over time, thereby to improve an accuracy level of tissue characterization.
Claim 47
Independent Claim
132 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue; wherein processing the detection spectrum further comprises averaging multiple ones of said detection spectra over time, thereby to improve an accuracy level of tissue characterization.
Claim 48
Independent Claim
132 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra and relating said detection spectra to said library; and identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue; wherein processing the detection spectrum further comprises averaging multiple ones of said detection spectra over time, thereby to improve an accuracy level of tissue characterization.
Claim 49
Dependent Claim
24 words
The method of claim 41 wherein processing said detection spectra further comprises providing a signal corresponding to a probabilistic strength of the tissue characterization.
Claim 50
Independent Claim
120 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra by and relating said detection spectra to said library; identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue; and providing a signal corresponding to a probabilistic strength of the tissue characterization.
Claim 51
Independent Claim
120 words
A method for characterizing tissue in vivo comprising: launching electromagnetic radiation into a tissue to be characterized; detecting electromagnetic radiation that has been modified by passage through said tissue as a detection spectra corresponding to at least one preselected wavelength of the detected electromagnetic radiation; providing a library of spectra records corresponding to a plurality of known tissue types; processing the detection spectra by and relating said detection spectra to said library; identifying the detection spectra as corresponding to one of one of said plurality of known tissue types in said library and none of said plurality of known tissue types, thereby to characterize the identified tissue; and providing a signal corresponding to a probabilistic strength of the tissue characterization.
References Cited (Backward Citations)
US5199431A
Cited
US4784150A
Cited
US4981138A
Cited
US4975581A
Cited
DE3920706A1
Cited
US5348018A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-07-27 | 2002-01-26 | 2002-07-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-27 | 2006-01-26 | 2006-07-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-27 | 2010-01-26 | 2010-07-28 | $7700.00 | Window Closed / Lapsed |