US5767158A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Endermic liniment
Assignee: Shiseido Co Ltd
•
Filing: 1996-02-13
•
Granted: 1998-06-16
•
Expires: 2016-02-13
Abstract
Abstract An endermic liniment containing at least one type of phenylalanine compound, and/or its salt, is disclosed. This endermic liniment has a melanin production suppression effect and is superior in terms of its skin whitening effect as in preventing and/or improving chloasma, freckles and pigmentation in the skin after sunburn. It is also stable and highly safe.
Inventors
- 👤 Masaru Suetsugu
- 👤 Satoshi Shinojima
- 👤 Okihiko Sakamoto
- 👤 Masayuki Asaike
- 👤 Yuki Shibata
- 👤 Rumiko Kaku
- 👤 Tsuneo Suehiro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:50
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/41; A61Q; A61Q19/00; A61Q19/004; A61Q19/02
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
64 words
An endermic liniment containing at least one type of phenylalanine compound selected from the group consisting of N-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-D-tyrosine, N-benzoyl-L-tyrosine, N-benzoyl-D-tyrosine, N-(p-methoxybenzoyl)-L-tyrosine, N-(p-methoxybenzoyl)-D-tyrosine, N-(p-hydroxybenzoyl)-L-tyrosine, N-(p-hydroxybenzoyl)-D-tyrosine, O-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine amide, 4-methoxy-L-phenylalanine, 4-methoxy-L-phenylalanine hydrochloride, 4-methoxy-DL-phenylalanine, N-benzyloxycarbonyl-O-benzyl-L-tyrosine, O-benzyl-L-tyrosine, O-phospho-L-tyrosine, O-phospho-DL-tyrosine, O-phospho-D-tyrosine, L-tyrosine β-naphthyl amide, N-tert-butoxycarbonyl-L-3,4-dihydroxyphenylalanine, N-tert-butoxycarbonyl-O-acetyl-L-tyrosine, N-tert-butoxycarbonyl-O-acetyl-D-tyrosine, N-tert-butoxycarbonyl-3,5-diiodo-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-D-tyrosine, N-tert-butoxycarbonyl-O-methyl-L-tyrosine, N-tert-butoxycarbonyl-L-tyrosine, N-tert-butoxycarbonyl-D-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-tert-butyl-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-3,5-diiodo-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-dimethylphospho-L-tyrosine, L-tyrosine amide, L-tyrosine hydrazide, DL-3-(2-hydroxyphenyl) alanine, and DL-o-tyrosine.
Claim 2
Dependent Claim
64 words
An endermic liniment containing at least one type of phenylalanine compound selected from the group consisting of N-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-D-tyrosine, N-benzoyl-L-tyrosine, N-benzoyl-D-tyrosine, N-(p-methoxybenzoyl)-L-tyrosine, N-(p-methoxybenzoyl)-D-tyrosine, N-(p-hydroxybenzoyl)-L-tyrosine, N-(p-hydroxybenzoyl)-D-tyrosine, O-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine amide, 4-methoxy-L-phenylalanine, 4-methoxy-L-phenylalanine hydrochloride, 4-methoxy-DL-phenylalanine, N-benzyloxycarbonyl-O-benzyl-L-tyrosine, O-benzyl-L-tyrosine, O-phospho-L-tyrosine, O-phospho-DL-tyrosine, O-phospho-D-tyrosine, L-tyrosine β-naphthyl amide, N-tert-butoxycarbonyl-L-3,4-dihydroxyphenylalanine, N-tert-butoxycarbonyl-O-acetyl-L-tyrosine, N-tert-butoxycarbonyl-O-acetyl-D-tyrosine, N-tert-butoxycarbonyl-3,5-diiodo-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-D-tyrosine, N-tert-butoxycarbonyl-O-methyl-L-tyrosine, N-tert-butoxycarbonyl-L-tyrosine, N-tert-butoxycarbonyl-D-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-tert-butyl-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-3,5-diiodo-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-dimethylphospho-L-tyrosine, L-tyrosine amide, L-tyrosine hydrazide, DL-3-(2-hydroxyphenyl) alanine, and DL-o-tyrosine.
Claim 3
Independent Claim
70 words
A method of bleaching skin comprising applying to the skin at least one type of compound selected from the group consisting of N-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-D-tyrosine, N-benzoyl-L-tyrosine, N-benzoyl-D-tyrosine, N-(p-methoxybenzoyl)-L-tyrosine, N-(p-methoxybenzoyl)-D-tyrosine, N-(p-hydroxybenzoyl)-L-tyrosine, N-(p-hydroxybenzoyl)-D-tyrosine, O-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine amide, 4-methoxy-L-phenylalanine, 4-methoxy-L-phenylalanine hydrochloride, 4-methoxy-DL-phenylalanine, N-benzyloxycarbonyl-O-benzyl-L-tyrosine, O-benzyl-L-tyrosine, O-phospho-L-tyrosine, O-phospho-DL-tyrosine, O-phospho-D-tyrosine, L-tyrosine β-naphthyl amide, N-tert-butoxycarbonyl-L-3, 4-dihydroxyphenylalanine, N-tert-butoxycarbonyl-O-acetyl-L-tyrosine, N-tert-butoxycarbonyl-O-acetyl-D-tyrosine, N-tert-butoxycarbonyl-3,5-diiodo-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-D-tyrosine, N-tert-butoxycarbonyl-O-methyl-L-tyrosine, N-tert-butoxycarbonyl-L-tyrosine, N-tert-butoxycarbonyl-D-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-tert-butyl-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-3,5-diiodo-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-dimethylphospho-L-tyrosine, L-tyrosine amide, L-tyrosine hydrazide, DL-3-(2-hydroxyphenyl) alanine, and DL-o-tyrosine.
Claim 4
Independent Claim
70 words
A method of bleaching skin comprising applying to the skin at least one type of compound selected from the group consisting of N-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-D-tyrosine, N-benzoyl-L-tyrosine, N-benzoyl-D-tyrosine, N-(p-methoxybenzoyl)-L-tyrosine, N-(p-methoxybenzoyl)-D-tyrosine, N-(p-hydroxybenzoyl)-L-tyrosine, N-(p-hydroxybenzoyl)-D-tyrosine, O-benzyloxycarbonyl-L-tyrosine, N-benzyloxycarbonyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine hydrazide, N-acetyl-L-tyrosine amide, 4-methoxy-L-phenylalanine, 4-methoxy-L-phenylalanine hydrochloride, 4-methoxy-DL-phenylalanine, N-benzyloxycarbonyl-O-benzyl-L-tyrosine, O-benzyl-L-tyrosine, O-phospho-L-tyrosine, O-phospho-DL-tyrosine, O-phospho-D-tyrosine, L-tyrosine β-naphthyl amide, N-tert-butoxycarbonyl-L-3, 4-dihydroxyphenylalanine, N-tert-butoxycarbonyl-O-acetyl-L-tyrosine, N-tert-butoxycarbonyl-O-acetyl-D-tyrosine, N-tert-butoxycarbonyl-3,5-diiodo-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-L-tyrosine, N-tert-butoxycarbonyl-O-ethyl-D-tyrosine, N-tert-butoxycarbonyl-O-methyl-L-tyrosine, N-tert-butoxycarbonyl-L-tyrosine, N-tert-butoxycarbonyl-D-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-tert-butyl-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-3,5-diiodo-L-tyrosine, N-9-fluorenylmethyloxycarbonyl-O-dimethylphospho-L-tyrosine, L-tyrosine amide, L-tyrosine hydrazide, DL-3-(2-hydroxyphenyl) alanine, and DL-o-tyrosine.
References Cited (Backward Citations)
EP0356119A1
Cited
FR2702959A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-15 | 2001-12-15 | 2002-06-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-15 | 2005-12-15 | 2006-06-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-15 | 2009-12-15 | 2010-06-16 | $7700.00 | Window Closed / Lapsed |