US5752941A
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Central venous catheters loaded with antibiotics of the ramoplanin group preventing development of catheter related infections
Assignee: Biosearch Italia SpA
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Filing: 1995-02-01
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Granted: 1998-05-19
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Expires: 2015-02-01
Abstract
Abstract PCT No. PCT/EP95/00355 Sec. 371 Date Aug. 2, 1996 Sec. 102(e) Date Aug. 2, 1996 PCT Filed Feb. 1, 1995 PCT Pub. No. WO95/21636 PCT Pub. Date Aug. 17, 1995The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.
Inventors
- 👤 Gabriella Romano'
- 👤 Beth P. Goldstein
- 👤 Rosamund Jean Williams
- 👤 Maurizio Denaro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:29
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L29/04; A61L29/06; A61L29/08; A61L29/085; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
97 words
A central venous catheter comprising a polyurethane catheter with a thin hydrophilic layer on the surface loaded with an antibiotic of the ramoplanin group in a concentration sufficient to inhibit the bacterial colonization of the catheter after insertion into the patient, wherein the antibiotic of the ramoplanin group is selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 factor A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, and any mixture thereof.
Claim 2
Dependent Claim
97 words
A central venous catheter comprising a polyurethane catheter with a thin hydrophilic layer on the surface loaded with an antibiotic of the ramoplanin group in a concentration sufficient to inhibit the bacterial colonization of the catheter after insertion into the patient, wherein the antibiotic of the ramoplanin group is selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 factor A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, and any mixture thereof.
Claim 3
Dependent Claim
19 words
A catheter of any of claims 1 wherein the thin hydrophilic layer is comprised of a poly-N-vinylpyrrolidone polyurethane interpolymer.
Claim 4
Dependent Claim
16 words
A catheter of claims 1 wherein the hydrophilic layer has a thickness of approximately 200 μm.
Claim 5
Dependent Claim
14 words
A catheter as in any of claims 1 wherein the antibiotic loaded is ramoplanin.
Claim 6
Dependent Claim
49 words
A catheter of claim 4 characterized in that, when incubated for one hour at room temperature in a 8M guanidine hydrochloride solution, it releases into the solution an amount of antibiotic that, when related to the catheter length, corresponds to a value ranging from 20 μg/cm to 100 μg/cm.
Claim 7
Dependent Claim
122 words
A process for preparing a central venous polyurethane catheter coated with a thin hydrophilic layer on the surface and loaded with an amount of an antibiotic of the ramoplanin group comprising incubation of the polyurethane catheter coated with the hydrophilic film in a solution of the antibiotic substance wherein the antibiotic is selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 factor A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, and any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, any mixture thereof; at a temperature between about 10° C. and 60° C. for a period of time between about 5 minutes and 48 hours.
Claim 8
Dependent Claim
122 words
A process for preparing a central venous polyurethane catheter coated with a thin hydrophilic layer on the surface and loaded with an amount of an antibiotic of the ramoplanin group comprising incubation of the polyurethane catheter coated with the hydrophilic film in a solution of the antibiotic substance wherein the antibiotic is selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 factor A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, and any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, any mixture thereof; at a temperature between about 10° C. and 60° C. for a period of time between about 5 minutes and 48 hours.
Claim 9
Dependent Claim
26 words
A process according to claim 6 in which the solution of the antibiotic substance is in a concentration range from about 1 to about 50 mg/ml.
Claim 10
Dependent Claim
18 words
A process according to claim 6 in which the solution of the antibiotic substance is an aqueous solution.
Claim 11
Dependent Claim
13 words
A process according to claim 6 in which the antibiotic substance is Ramoplanin.
Claim 12
Independent Claim
90 words
A method for preventing catheter related infection in a patient in need of there comprising the insertion of a central venous polyurethane catheter coated with a thin hydrophilic layer on the surface loaded with an amount of an antibiotic of the ramoplanin group selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, and any mixture thereof.
Claim 13
Independent Claim
90 words
A method for preventing catheter related infection in a patient in need of there comprising the insertion of a central venous polyurethane catheter coated with a thin hydrophilic layer on the surface loaded with an amount of an antibiotic of the ramoplanin group selected from the group consisting of antibiotic A/16686 factor A1, antibiotic A/16686 factor A2, antibiotic A/16686 factor A3, antibiotic A/16686 A'1, antibiotic A/16686 factor A'2, antibiotic A/16686 factor A'3, any of the derivatives thereof hydrogenated in the fatty acid chain, any aglycons thereof, and any mixture thereof.
Claim 14
Dependent Claim
11 words
A method as in claim 10 wherein the antibiotic is ramoplanin.
Claim 15
Dependent Claim
25 words
A central venous polyurethane catheter comprising a polyurethane catheter coated with coating composition which incorporates an antibiotic substance of ramoplanin group and a hydrophilic layer.
Claim 16
Dependent Claim
25 words
A central venous polyurethane catheter comprising a polyurethane catheter coated with coating composition which incorporates an antibiotic substance of ramoplanin group and a hydrophilic layer.
Claim 17
Dependent Claim
68 words
A process for preparing a central venous polyurethane catheter with a hydrophilic layer on the surface of the catheter and incorporating an antibiotic substance of the ramoplanin group comprising incubation of the polyurethane catheter coated with the hydrophilic film in a solution of the antibiotic substance at a temperature between about 10° C. and 600° C. for a period of time between about 5 minutes and 48 hours.
Claim 18
Dependent Claim
68 words
A process for preparing a central venous polyurethane catheter with a hydrophilic layer on the surface of the catheter and incorporating an antibiotic substance of the ramoplanin group comprising incubation of the polyurethane catheter coated with the hydrophilic film in a solution of the antibiotic substance at a temperature between about 10° C. and 600° C. for a period of time between about 5 minutes and 48 hours.
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