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US5747045A Expired / Lapsed US ⏱️ 0.0 years remaining

Avian polyomavirus vaccine in psittacine birds

Assignee: University of Georgia Research Foundation Inc
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Filing: 1996-06-03
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Granted: 1998-05-05
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Expires: 2016-06-03
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Abstract

Abstract The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of an inactivated avian polyomavirus in a pharmaceutically acceptable carrier. Also provided is a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order, comprising an immunogenic amount of a recombinant protein derived from an avian polyomavirus and a pharmaceutically acceptable carrier. Also provided is an adjuvant suitable for use in a bird which is classified as being a member of the Psittaciformes order. Further provided is a composition which produces an anamnestic response against avian polyomavirus infection in a sensitized bird which is classified as being a member of the Psittaciformes order, which comprises an anamnestic response inducing amount of a recombinant protein (e.g., VP1 capsid protein) of avian polyomavirus in a pharmaceutically acceptable carrier. Methods are also provided for preventing avian polyomavirus infection in a bird, or in several different species of birds, classified as being a member of the Psittaciformes order, comprising administering a vaccine comprising an immunogenic amount of a inactivated avian polyomavirus and a pharmaceutically acceptable carrier.

Inventors

  • 👤 Branson W. Ritchie
  • 👤 Frank D. Niagro
  • 👤 Kenneth S. Latimer

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 15:48
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K38/00; C12; C12N; C12N2710/00; C12N2710/00011; C12N2710/22011; C12N2710/22022; Y; Y02; Y02A; Y02A50/00; Y02A50/30

Claims Analysis

Total Claims: 19
Claim 1
Independent Claim 42 words
A vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order, comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim 42 words
A vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order, comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim 26 words
The vaccine of claim 1, further comprising an adjuvant suitable for use in a bird which is classified as being a member of the Psittaciformes order.
Claim 4
Dependent Claim 22 words
The vaccine of claim 2, wherein the adjuvant is a long chain polydispersed B (1,4) linked mannan polymer interspersed with O-acetylated groups.
Claim 5
Dependent Claim 23 words
The vaccine of claim 2, wherein the adjuvant is a deproteinized highly purified cell wall extract of a non-pathogenic strain of Mycobacterium species.
Claim 6
Dependent Claim 11 words
The vaccine of claim 2, wherein the adjuvant is aluminum hydroxide.
Claim 7
Dependent Claim 24 words
The vaccine of claim 1, wherein the immunogenic amount of the recombinant protein of an avian polyomavirus is between 1.0 mg. and 3 mg.
Claim 8
Dependent Claim 32 words
The vaccine of claim 1, wherein the bird is selected from the group consisting of a macaw, an Amazon parrot, a conure, a cockatoo, a Pionus Parrot, and an African Grey Parrot.
Claim 9
Independent Claim 47 words
A method of preventing avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order, comprising administering to the bird a vaccine comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.
Claim 10
Independent Claim 47 words
A method of preventing avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order, comprising administering to the bird a vaccine comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim 28 words
The method of claim 8, wherein the vaccine further comprises an adjuvant suitable for use in a bird which is classified as a member of the Psittaciformes order.
Claim 12
Dependent Claim 22 words
The method of claim 9, wherein the adjuvant is a long chain polydispersed B (1,4) linked mannan polymer interspersed with O-acetylated groups.
Claim 13
Dependent Claim 23 words
The method of claim 9, wherein the adjuvant is a deproteinized highly purified cell wall extract of a non-pathogenic strain of Mycobacterium species.
Claim 14
Dependent Claim 11 words
The method of claim 9, wherein the adjuvant is aluminum hydroxide.
Claim 15
Dependent Claim 24 words
The method of claim 8, wherein the immunogenic amount of the recombinant protein of an avian polyomavirus is between 1.0 mg. and 3 mg.
Claim 16
Dependent Claim 32 words
The method of claim 8, wherein the bird is selected from the group consisting of a macaw, an Amazon parrot, a conure, a cockatoo, a Pionus Parrot, and an African Grey Parrot.
Claim 17
Dependent Claim 16 words
The method of claim 8, further comprising administering at least one booster vaccine to the bird.
Claim 18
Independent Claim 48 words
A method of preventing avian polyomavirus infection in a sensitized bird which is classified as being a member of the Psittaciformes order, comprising administering to the bird a vaccine comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.
Claim 19
Independent Claim 48 words
A method of preventing avian polyomavirus infection in a sensitized bird which is classified as being a member of the Psittaciformes order, comprising administering to the bird a vaccine comprising an immunogenic amount of a recombinant VP1 capsid protein of an avian polyomavirus and a pharmaceutically acceptable carrier.

References Cited (Backward Citations)

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3.5 Years (Year 4) 2001-05-04 2001-11-03 2002-05-05 $2000.00 Window Closed / Lapsed
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