US5744161A
Expired / Lapsed
US
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Use of piperine as a bioavailability enhancer
Assignee: Sami Chemicals and Extracts Ltd
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Filing: 1995-10-30
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Granted: 1998-04-28
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Expires: 2015-10-30
Abstract
Abstract Compositions and methods for the improvement of gastrointestinal absorption and systemic utilization of nutrients and nutritional supplements, wherein the compositions comprise a minimum of 98% of pure alkaloid piperine. The method comprises oral, topical, or parenteral administration of the compositions of the invention. A new process for the extraction and purification of piperine is also disclosed.
Inventors
- 👤 Muhammed Majeed
- 👤 Vladimir Badmaev
- 👤 Ramaswamy Rajendran
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:00
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/60; A; A23; A23L; A23L27/00; A23L27/10; A23L27/11; A23L33/00; A23L33/10; A23L33/105; A61; A61K; A61K47/00; A61K47/06; A61K47/22; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0019; A61P; A61P3/00; A61P3/04; A61P39/00; A61P39/06; A61P43/00
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
54 words
A composition suitable for improving gastrointestinal absorption and systemic utilization of nutritional materials, subsequent increase in nutrient induced thermogenesis, and increase in lean body mass, comprising at least one nutritional material in a nutritionally effective amount and a bioavailability enhancing effective amount of a bioavailability enhancer comprising at least 98% of the alkaloid piperine.
Claim 2
Dependent Claim
54 words
A composition suitable for improving gastrointestinal absorption and systemic utilization of nutritional materials, subsequent increase in nutrient induced thermogenesis, and increase in lean body mass, comprising at least one nutritional material in a nutritionally effective amount and a bioavailability enhancing effective amount of a bioavailability enhancer comprising at least 98% of the alkaloid piperine.
Claim 3
Dependent Claim
19 words
The composition of claim 1 wherein the piperine is obtained from an extract of fruits of the family Piperaceae.
Claim 4
Dependent Claim
19 words
The composition of claim 1 wherein the piperine is extracted from the fruit of piper nigrum or black pepper.
Claim 5
Dependent Claim
16 words
The composition of claim 1 wherein the piperine is extracted from the fruit of piper longum.
Claim 6
Dependent Claim
15 words
The composition of claim 1, which contains additionally an extract from the root zingiber officinale.
Claim 7
Dependent Claim
42 words
The composition of claim 1 wherein the nutritional materials comprise one or more members selected from the group consisting of herbal extracts, water soluble vitamins, fat soluble vitamins, amino acids, minerals, anti-oxidants, and combinations containing at least two of the nutritional materials.
Claim 8
Dependent Claim
28 words
The composition of claim 6 wherein the herbal extracts comprise one or more members selected from the group consisting of curcumin, boswellin, ashwagandha, ginkgo biloba, capsaicin, and aconitine.
Claim 9
Dependent Claim
31 words
The composition of claim 6 wherein the water soluble vitamins comprise one or more members selected from the group consisting of B1, B2, niacinamide, B6, B12, folic acid, and vitamin C.
Claim 10
Dependent Claim
38 words
The composition of claim 6 wherein the antioxidants comprise one or more members selected from the group consisting of vitamin A, vitamin C, vitamin E, alpha-carotene, transbeta-carotene, betacryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavonals complex, germanium, selenium, and zinc.
Claim 11
Dependent Claim
30 words
The composition of claim 6 wherein the amino acids comprise one or more members selected from the group consisting of lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, methionine, and L-selenomethionine.
Claim 12
Dependent Claim
31 words
The composition of claim 6 wherein the minerals comprise one or more members selected from the group consisting of calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, and magnesium.
Claim 13
Dependent Claim
32 words
The composition of claim 1 which contains an extract from the fruit of piper nigrum, an extract from the fruit of piper longum, and an extract from the root of zingiber officinale.
Claim 14
Dependent Claim
20 words
The composition of claim 1, suitable for oral administration, in a unit dose form of 0.0004-0.15 mg/kg of body weight.
Claim 15
Dependent Claim
21 words
The composition of claim 1, suitable for topical or parenteral use, containing the unit dose of 0.00004-0.015 mg/kg of body weight.
Claim 16
Independent Claim
59 words
A method for improving gastrointestinal absorption and systemic utilization of nutritional materials subsequent increase in nutrient induced thermogenesis, and increase in lean body mass; said method comprising administering a composition containing at least one nutritional material, a bioavailability enhancing effective amount of a bioavailability enhancer comprising at least 98% alkaloid piperine, to a subject in need of such treatment.
Claim 17
Independent Claim
59 words
A method for improving gastrointestinal absorption and systemic utilization of nutritional materials subsequent increase in nutrient induced thermogenesis, and increase in lean body mass; said method comprising administering a composition containing at least one nutritional material, a bioavailability enhancing effective amount of a bioavailability enhancer comprising at least 98% alkaloid piperine, to a subject in need of such treatment.
Claim 18
Dependent Claim
20 words
The method of claim 15 wherein the piperine is obtained from an extract from the fruits of the family Piperaceae.
Claim 19
Dependent Claim
19 words
The method of claim 16 wherein the piperine is extracted from the fruit of piper nigrum or black pepper.
Claim 20
Dependent Claim
16 words
The method of claim 16 wherein the piperine is extracted from the fruit of piper longum.
Claim 21
Dependent Claim
15 words
The method of claim 15, which contains additionally an extract from the root zingiber officinale.
Claim 22
Dependent Claim
43 words
The method of claim 15 wherein the nutritional materials comprise one or more members selected from the group consisting of herbal extracts, water soluble vitamins, fat soluble vitamins, amino acids, minerals, anti-oxidants, and combinations containing two or more of the above nutritional materials.
Claim 23
Dependent Claim
28 words
The method of claim 20 wherein the herbal extracts comprise one or more members selected from the group consisting of curcumin, boswellin, ashwagandha, ginkgo biloba, capsaicin, and aconitine.
Claim 24
Dependent Claim
31 words
The method of claim 20 wherein the water soluble vitamins comprise one or more members selected from the group consisting of B1, B2, niacinamide, B6, B12, folic acid, and vitamin C.
Claim 25
Dependent Claim
38 words
The method of claim 20 wherein the antioxidants comprise one or more members selected from the group consisting of vitamin A, vitamin C, vitamin E, alpha-carotene, transbeta-carotene, betacryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavonals complex, germanium, selenium, and zinc.
Claim 26
Dependent Claim
30 words
The method of claim 20 wherein the amino acids comprise one or more members selected from the group consisting of lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, methionine, and L-selenomethionine.
Claim 27
Dependent Claim
31 words
The method of claim 20 wherein the minerals comprise one or more members selected from the group consisting of calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, and magnesium.
Claim 28
Dependent Claim
30 words
The method of claim 15 which contains an extract from the fruit of piper nigrum, extract from the fruit of piper lungum, and extract from the root of zingiber officinale.
Claim 29
Dependent Claim
11 words
The method of claim 15 wherein the composition is administered orally.
Claim 30
Dependent Claim
13 words
The method of claim 15 wherein the composition is administered topically or parenterally.
Claim 31
Dependent Claim
11 words
The method of claim 15 wherein the composition is administered topically.
Claim 32
Dependent Claim
11 words
The method of claim 16 wherein the composition is administered parenterally.
Claim 33
Dependent Claim
12 words
The method of claim 16 wherein the animal is a nonhuman animal.
Claim 34
Dependent Claim
11 words
The method of claim 16 wherein the animal is a mammal.
Claim 35
Independent Claim
88 words
A method for the purification of piperine to greater than 98% comprising a) providing a source of piperine; b) adding the material of step a) to butanol and hexane; c) heat to 40° Celsius; d) cooling and filtering the material of step c); e) washing the precipitate with butanol/hexane mixture to obtain crude piperine; f) dissolving the material of step e) in methanol at 60° C.; g) adding alumina and charcoal by stirring to the material of step f) and filtering; and h) concentrating the filter under vacuum.
Claim 36
Independent Claim
88 words
A method for the purification of piperine to greater than 98% comprising a) providing a source of piperine; b) adding the material of step a) to butanol and hexane; c) heat to 40° Celsius; d) cooling and filtering the material of step c); e) washing the precipitate with butanol/hexane mixture to obtain crude piperine; f) dissolving the material of step e) in methanol at 60° C.; g) adding alumina and charcoal by stirring to the material of step f) and filtering; and h) concentrating the filter under vacuum.
Claim 37
Dependent Claim
18 words
The method of claim 33 wherein the source of piperine is oleoresin from black pepper or long pepper.
Claim 38
Dependent Claim
17 words
The method of claim 33 wherein the source of piperine is ground black pepper or long pepper.
References Cited (Backward Citations)
US4284657A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-27 | 2001-10-27 | 2002-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-27 | 2005-10-27 | 2006-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-27 | 2009-10-27 | 2010-04-28 | $7700.00 | Window Closed / Lapsed |