US5743266A
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Method for processing real-time contrast enhanced ultrasonic images
Assignee: Molecular Biosystems Inc
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Filing: 1995-04-25
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Granted: 1998-04-28
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Expires: 2015-04-25
Abstract
Abstract The present invention is a novel method for producing real-time colorized, contrast enhanced images from a sequence of grey-scale video images obtained during diagnostic ultrasound. The particular colorizing scheme varies according to which information parameter is desired to be displayed in real-time. The information parameters used to colorize a segment of video images include: time-to-arrival, duration of brightening, and absolute brightening. Time-to-arrival colorization depicts the time that a given pixel achieves a given intensity threshold. Duration of brightening depicts the time that a given pixel's intensity stays above a given threshold. Absolute brightening depicts various threshold values obtained by the region's pixels.
Inventors
- 👤 Harold Levene
- 👤 Bob Webster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:35
CPC Classifications
A; A61; A61B; A61B8/00; A61B8/48; A61B8/481; A61B8/06; G; G01; G01S; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/899; G01S7/00; G01S7/52; G01S7/52017; G01S7/52053; G01S7/52057; G01S7/52071
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
137 words
A method of colorizing corresponding points in a region of interest of a subject in a series of grey-scale ultrasound images comprising: a) commencement of grey scale imaging of the region of interest of the subject; b) administration of contrast agent to the subject wherein the contrast agent perfuses to the region of interest; c) for the first image to be colorized, colorize each corresponding point according to the results of a comparison between a parameter and the value of the reflected signal of the corresponding point; and d) for each subsequent image in the series, colorizing each corresponding point according to the results of a comparison made between a parameter, the value of the reflected signal from the corresponding point in the image and a previous non-baseline value of the reflected signal of the corresponding point.
Claim 2
Independent Claim
137 words
A method of colorizing corresponding points in a region of interest of a subject in a series of grey-scale ultrasound images comprising: a) commencement of grey scale imaging of the region of interest of the subject; b) administration of contrast agent to the subject wherein the contrast agent perfuses to the region of interest; c) for the first image to be colorized, colorize each corresponding point according to the results of a comparison between a parameter and the value of the reflected signal of the corresponding point; and d) for each subsequent image in the series, colorizing each corresponding point according to the results of a comparison made between a parameter, the value of the reflected signal from the corresponding point in the image and a previous non-baseline value of the reflected signal of the corresponding point.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein the contrast agent is chosen from the group consisting of liquid emulsions, solids, encapsulated fluids, encapsulated biocompatible gases and combinations thereof.
Claim 4
Dependent Claim
15 words
The method of claim 2 wherein the contrast agent comprises a fluorinated gas or liquid.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the imaging is performed two-dimensionally.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein the imaging is performed three-dimensionally.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein said parameter is the time of arrival of the contrast agent.
Claim 8
Dependent Claim
27 words
The method of claim 1 wherein said parameter is the instantaneous degree of brightening of the tissue as a result of the arrival of the contrast agent.
Claim 9
Dependent Claim
27 words
The method of claim 1 wherein said parameter is the integrated degree of brightening of the tissue as the result of the arrival of the contrast agent.
Claim 10
Dependent Claim
24 words
The method of claim 1 wherein said parameter is the duration of the brightening by the contrast agent as it remains in the tissue.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein each said corresponding point is a pixel.
Claim 12
Independent Claim
102 words
A method of diagnosing tissue/organ condition comprising: a) commencement of grey scale imaging to obtain at least one baseline image; b) administration of contrast agent to the subject for the obtainance of non-baseline images; c) processing of images by colorization in real-time, wherein the colorization is made to corresponding points in said images in accordance with a parameter and two values of the reflected signal at the corresponding points, wherein one said value is derived from the current image being processed and the other said value is selectable from the set of baseline and non-baseline images; and d) analyzing the colorized images.
Claim 13
Independent Claim
102 words
A method of diagnosing tissue/organ condition comprising: a) commencement of grey scale imaging to obtain at least one baseline image; b) administration of contrast agent to the subject for the obtainance of non-baseline images; c) processing of images by colorization in real-time, wherein the colorization is made to corresponding points in said images in accordance with a parameter and two values of the reflected signal at the corresponding points, wherein one said value is derived from the current image being processed and the other said value is selectable from the set of baseline and non-baseline images; and d) analyzing the colorized images.
Claim 14
Dependent Claim
26 words
The method of claim 11 wherein contrast agent is chosen from the group consisting of liquid emulsions, solids, encapsulated fluids, encapsulated biocompatible gases and combinations thereof.
Claim 15
Dependent Claim
15 words
The method of claim 12 wherein the contrast agent comprises a fluorinated gas or liquid.
Claim 16
Dependent Claim
11 words
The method of claim 11 wherein the imaging is performed two-dimensionally.
Claim 17
Dependent Claim
11 words
The method of claim 11 wherein the imaging is performed three-dimensionally.
Claim 18
Dependent Claim
17 words
The method of claim 11 wherein said parameter is the time of arrival of the contrast agent.
Claim 19
Dependent Claim
27 words
The method of claim 11 wherein said parameter is the instantaneous degree of brightening of the tissue as a result of the arrival of the contrast agent.
Claim 20
Dependent Claim
27 words
The method of claim 11 wherein said parameter is the integrated degree of brightening of the tissue as the result of the arrival of the contrast agent.
Claim 21
Dependent Claim
24 words
The method of claim 11 wherein said parameter is the duration of the brightening by the contrast agent as it remains in the tissue.
Claim 22
Dependent Claim
13 words
The method of claim 11 wherein the tissue being diagnosed comprises the heart.
Claim 23
Dependent Claim
19 words
The method of claim 20 wherein the processing is performed at more than one point in the cardiac cycle.
Claim 24
Independent Claim
15 words
The method of claims 20 or 21 wherein the colorization includes the left ventricle region.
Claim 25
Independent Claim
17 words
The method of claims 20 or 21 wherein the colorization does not include the left ventricle region.
Claim 26
Dependent Claim
12 words
The method of claim 11 wherein the tissue being diagnosed comprises kidney.
Claim 27
Dependent Claim
13 words
The method of claim 11 wherein the tissue being diagnosed comprises the brain.
Claim 28
Dependent Claim
13 words
The method of claim 11 wherein the tissue being diagnosed comprises the liver.
Claim 29
Dependent Claim
13 words
The method of claim 11 wherein the tissue being diagnosed comprises the testes.
Claim 30
Dependent Claim
13 words
The method of claim 11 wherein the tissue being diagnosed comprises muscle tissue.
Claim 31
Dependent Claim
16 words
The method of claim 11 wherein the tissue being diagnosed comprises the blood flow within tissue/organ.
Claim 32
Dependent Claim
19 words
The method of claim 11 wherein the processing is performed at more than one point in the cardiac cycle.
Claim 33
Dependent Claim
13 words
The method of claim 11 wherein each said corresponding point is a pixel.
Claim 34
Independent Claim
186 words
A method for producing a series of real-time colorized images of corresponding points in a region of interest, said images taken with an ultrasound diagnostic scanning apparatus or an ultrasound image processing apparatus wherein the apparatus processes the series of grey scale images according to a pre-determined parameter; the steps of the method comprise: (a) identifying a region of interest in the images for processing; (b) for the first grey scale image in the series, (i) determining the value of the reflected signal of the corresponding point; (ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter and the value determined in step (b)(ii), (c) for each subsequent grey scale image, (i) determining the value of the reflected signal of the corresponding point in the current image; (ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter, the value of the reflected signal of the corresponding point in the current image and the value of the reflected signal of the corresponding point in a previous image, wherein such previous image is selectable from the set of baseline and non-baseline images.
Claim 35
Independent Claim
186 words
A method for producing a series of real-time colorized images of corresponding points in a region of interest, said images taken with an ultrasound diagnostic scanning apparatus or an ultrasound image processing apparatus wherein the apparatus processes the series of grey scale images according to a pre-determined parameter; the steps of the method comprise: (a) identifying a region of interest in the images for processing; (b) for the first grey scale image in the series, (i) determining the value of the reflected signal of the corresponding point; (ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter and the value determined in step (b)(ii), (c) for each subsequent grey scale image, (i) determining the value of the reflected signal of the corresponding point in the current image; (ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter, the value of the reflected signal of the corresponding point in the current image and the value of the reflected signal of the corresponding point in a previous image, wherein such previous image is selectable from the set of baseline and non-baseline images.
Claim 36
Dependent Claim
12 words
The method of claim 32 wherein the method further comprises two-dimensional imaging.
Claim 37
Dependent Claim
12 words
The method of claim 32 wherein the method further comprises three-dimensional imaging.
Claim 38
Dependent Claim
16 words
The method of claim 32 wherein said parameter is the time of arrival of contrast agent.
Claim 39
Dependent Claim
28 words
The method of claim 32 wherein said parameter is the instantaneous degree of brightening of the region of interest as a result of the arrival of contrast agent.
Claim 40
Dependent Claim
28 words
The method of claim 32 wherein said parameter is the integrated degree of brightening of the region of interest as the result of the arrival of contrast agent.
Claim 41
Dependent Claim
25 words
The method of claim 32 wherein said parameter is the duration of brightening by the contrast agent as it remains in the region of interest.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-27 | 2001-10-27 | 2002-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-27 | 2005-10-27 | 2006-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-27 | 2009-10-27 | 2010-04-28 | $7700.00 | Window Closed / Lapsed |