US5741409A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sensor membranes
Assignee: The University of Sydney
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Filing: 1997-04-09
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Granted: 1998-04-21
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Expires: 2017-04-09
Abstract
Abstract The present invention relates to novel electrode membrane combination. This novel combination employs compounds include a linker lipid for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode, the electrode being either in part or totally made up of the linker lipid. The linker lipid comprises within the same molecule a hydrophobic region capable of spanning the membrane, an attachment group used to attach the molecule to an electrode surface, a hydrophilic region intermediate said hydrophobic region and the attachment group and a polar head group region attached to the hydrophobic region at a site remote from the hydrophilic region.
Inventors
- 👤 Burkhard Raguse
- 👤 Bruce A Cornell
- 👤 Vijoleta L Braach-Maksvytis
- 👤 Ronald J Pace
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:56
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54373; B; B01; B01D; B01D69/00; B01D69/12; B01D69/122; C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; C12Q1/003; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/327; G01N31/00; G01N31/22; G01N31/221; G01N33/5438; G01N2410/00; G01N2410/10; Y; Y10; Y10S; Y10S435/00; Y10S435/817
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
101 words
An electrode membrane combination comprising an electrode and an ionically insulating monolayer membrane, the membrane comprising a closely packed array of amphiphilic molecules and a plurality of ionophores dispersed therein, said amphiphilic molecules comprising within the same molecule a hydrophobic region, an attachment region attached to the electrode, a hydrophilic region intermediate said hydrophobic and attachment regions, the space formed by said hydrophilic region between the electrode and the membrane being sufficient to allow the flux of ions through the ionophores, and a head group attached to the hydrophobic portion of the molecule at a site remote from the hydrophilic region.
Claim 2
Dependent Claim
101 words
An electrode membrane combination comprising an electrode and an ionically insulating monolayer membrane, the membrane comprising a closely packed array of amphiphilic molecules and a plurality of ionophores dispersed therein, said amphiphilic molecules comprising within the same molecule a hydrophobic region, an attachment region attached to the electrode, a hydrophilic region intermediate said hydrophobic and attachment regions, the space formed by said hydrophilic region between the electrode and the membrane being sufficient to allow the flux of ions through the ionophores, and a head group attached to the hydrophobic portion of the molecule at a site remote from the hydrophilic region.
Claim 3
Dependent Claim
47 words
An electrode membrane combination as claimed in claim 1 in which the monolayer membrane molecule has a hydrophobic region that consists of oligomers of long chain amino acids, where the amino acids are linked via amide linkages that are substituted at the nitrogen with hydrocarbon alkane groups.
Claim 4
Dependent Claim
53 words
An electrode membrane combination as claimed in claim 2 in which the structure of the amino acids is such that the amino group is separated from the acid group by an alkane chain of between 6-20 carbons long, and that the alkane chains attached to the nitrogen are between 10-20 carbon atoms long.
Claim 5
Dependent Claim
24 words
An electrode membrane combination as claimed in claim 3 in which the alkane groups are phytanyl groups or other mono- or permethylated hydrocarbon groups.
Claim 6
Dependent Claim
57 words
An electrode membrane combination as claimed in claim 1 in which the membrane consists of a monolayer membrane molecule where the hydrophobic region consists in a tertiary, trialkyl amine that is functionalised at two of the alkyl chains such that the tertiary amine is attached to a monoalkylsubstituted glycerol, monoalkyl substituted glutamic acid to form dialkyl lipids.
Claim 7
Dependent Claim
49 words
An electrode membrane combination as claimed in claim 1 in which the membrane consists in a monolayer membrane where the hydrophobic region consists in a tetra alkylated pentaerythritol derivative where two of the alkyl chains are functionalised so as to allow attachment to monoalkyl substituted glycerol or glutamic acid.
Claim 8
Dependent Claim
43 words
An electrode membrane combination as claimed in claim 1 in which the ionophore is capable of transporting an ion that is produced by the reaction of an enzyme with its substrate, said enzyme being either covalently or non-covalently attached to the membrane surface.
Claim 9
Dependent Claim
16 words
An electrode membrane combination as claimed in claim 7 in which the enzyme is a urease.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-20 | 2001-10-20 | 2002-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-20 | 2005-10-20 | 2006-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-20 | 2009-10-20 | 2010-04-21 | $7700.00 | Window Closed / Lapsed |