US5740270A
Expired / Lapsed
US
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Automated cytological specimen classification system and method
Assignee: TriPath Imaging Inc
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Filing: 1995-06-07
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Granted: 1998-04-14
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Expires: 2015-06-07
Abstract
Abstract A method of determining the reliability of a cytological screening test including the steps of viewing at least part of a cytological specimen, creating an image of the view, producing a digital representation of the image, ranking objects in the digital representation based on the degree to which each respective object has characteristics more likely found in a typical premalignant or malignant cell than in a typical benign cell, and displaying for review by an operator the images of at least a minimum number of the highest ranked objects such that objects of a predetermined cell type are displayed in the absence of premalignant or malignant cells, wherein the detection by the operator of the presence in the display of at least one cell of the predetermined cell type tends to indicate that the test is reliable.
Inventors
- 👤 Mark R. Rutenberg
- 👤 Thomas L. Hall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 12:55
CPC Classifications
G; G06; G06N; G06N3/00; G06N3/02; G06N3/04; G01; G01N; G01N1/00; G01N1/28; G01N1/30; G01N15/00; G01N15/10; G01N15/14; G01N15/1429; G01N15/1433; G06N3/0499; G06N3/08; G06N3/09; G06V; G06V20/00; G06V20/60; G06V20/69; G06V20/693; G01N1/44; G01N2203/00; G01N2203/02; G01N2203/06; G01N2203/0641; G01N2203/0647; Y; Y10; Y10S; Y10S128/00; Y10S128/92; Y10T; Y10T436/00; Y10T436/11
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
145 words
A method of determining the reliability of cytological screening test, comprising the steps of: a) viewing at least part of a cytological specimen; b) creating an image of the view; c) producing a digital representation of the image; d) ranking individual objects in an order in the digital representation based on the degree to which each respective object has characteristics more likely found in a typical premalignant or malignant cell than in a typical benign cell; and e) displaying for review by an operator the images of at least a minimum number of the highest ranked objects such that objects of a predetermined cell type are displayed in the absence of premalignant or malignant cells; wherein the detection by the operator of the presence in the display of at least one cell of the predetermined cell type tends to indicate that the test is reliable.
Claim 2
Independent Claim
145 words
A method of determining the reliability of cytological screening test, comprising the steps of: a) viewing at least part of a cytological specimen; b) creating an image of the view; c) producing a digital representation of the image; d) ranking individual objects in an order in the digital representation based on the degree to which each respective object has characteristics more likely found in a typical premalignant or malignant cell than in a typical benign cell; and e) displaying for review by an operator the images of at least a minimum number of the highest ranked objects such that objects of a predetermined cell type are displayed in the absence of premalignant or malignant cells; wherein the detection by the operator of the presence in the display of at least one cell of the predetermined cell type tends to indicate that the test is reliable.
Claim 3
Dependent Claim
29 words
The method of claim 1, wherein said step of ranking includes identifying objects in the digital representation as likely to be premalignant or malignant based on a detectable feature.
Claim 4
Dependent Claim
40 words
The method of claim 2, wherein said step of ranking further includes using a neural computer apparatus to further classify such identified objects as likely to be malignant or premalignant as a function of training of the neural computer apparatus.
Claim 5
Dependent Claim
14 words
The method of claim 1, wherein the predetermined cell type is an endocervical cell.
Claim 6
Dependent Claim
21 words
The method of claim 1, wherein said step of displaying includes arranging each displayed object in the order of its ranking.
Claim 7
Dependent Claim
18 words
The method of claim 5, wherein said step of arranging includes arranging the objects in a matrix format.
Claim 8
Dependent Claim
15 words
The method of claim 6, wherein said matrix format is an 8 by 8 matrix.
Claim 9
Independent Claim
122 words
A method of facilitating the determination of the presence of an infection in a cytological specimen, comprising the steps of: a) viewing at least part of cytological specimen; b) creating an image of the view; c) producing a digital representation of the image; d) ranking individual objects in the digital representation in an order based on the degree to which each respective object has characteristics more likely found in a typical premalignant or malignant cell than in a typical benign cell; and e) displaying for review by an operator the images of at least a minimum number of the highest ranked objects such that objects representative of cells having indications of infection are displayed in the absence of premalignant or malignant cells.
Claim 10
Independent Claim
122 words
A method of facilitating the determination of the presence of an infection in a cytological specimen, comprising the steps of: a) viewing at least part of cytological specimen; b) creating an image of the view; c) producing a digital representation of the image; d) ranking individual objects in the digital representation in an order based on the degree to which each respective object has characteristics more likely found in a typical premalignant or malignant cell than in a typical benign cell; and e) displaying for review by an operator the images of at least a minimum number of the highest ranked objects such that objects representative of cells having indications of infection are displayed in the absence of premalignant or malignant cells.
Claim 11
Dependent Claim
29 words
The method of claim 8, wherein said step of ranking includes identifying objects in the digital representation as likely to be premalignant or malignant based on a detectable feature.
Claim 12
Dependent Claim
40 words
The method of claim 9, wherein said step of ranking further includes using a neural computer apparatus to further classify the identified objects as likely to be malignant or premalignant as a function of training of the neural computer apparatus.
Claim 13
Dependent Claim
21 words
The method of claim 8, wherein said step of displaying includes arranging each displayed object in the order of its ranking.
Claim 14
Dependent Claim
18 words
The method of claim 11, wherein said step of arranging includes arranging the objects in a matrix format.
Claim 15
Dependent Claim
15 words
The method of claim 12, wherein said matrix format is an 8 by 8 matrix.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-13 | 2001-10-13 | 2002-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-13 | 2005-10-13 | 2006-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-13 | 2009-10-13 | 2010-04-14 | $7700.00 | Window Closed / Lapsed |