US5738902A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible coated article
Assignee: Cobe Cardiovascular Inc
•
Filing: 1996-10-10
•
Granted: 1998-04-14
•
Expires: 2016-10-10
Abstract
Abstract The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.
Inventors
- 👤 Lloyd Forrestal
- 👤 Marc Voorhees
- 👤 Harold Fisher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:58
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L31/00; A61L31/08; A61L31/10; A61L33/00; A61L33/06; A61L33/068; C; C09; C09D; C09D183/00; C09D183/10; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978; Y10T428/24998; Y10T428/249987; Y10T428/249991; Y10T428/249992; Y10T428/31504; Y10T428/31652; Y10T428/31663; Y10T428/31667; Y10T428/31678; Y10T428/31681; Y10T428/31786; Y10T428/31797
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
58 words
A method of coating a porous membrane with an polylactone-polysiloxane-polyactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 2
Independent Claim
58 words
A method of coating a porous membrane with an polylactone-polysiloxane-polyactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 3
Dependent Claim
15 words
A method according to claim 1 wherein the porous membrane is a polypropylene microporous membrane.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the X-ray fluorescence relative intensity range is 0.05 to 0.25.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the X-ray fluorescence relative intensity range is in the range 0.16 to 0.20.
Claim 6
Dependent Claim
25 words
A method according to claim 1 comprising the additional step of subjecting the coated membrane to ionizing radiation to produce an insoluble and adhering coating.
Claim 7
Dependent Claim
21 words
A method according to claim 5 wherein the ionizing radiation is in the form of x-rays, γ-rays or an electron beam.
Claim 8
Dependent Claim
20 words
A method according to claim 5 wherein the radiation is x-rays in the dose range of 0.25 to 13.0 Mrad.
Claim 9
Independent Claim
66 words
A method of coating a porous membrane with an polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 10
Independent Claim
66 words
A method of coating a porous membrane with an polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
Claim 11
Dependent Claim
15 words
A method according to claim 8 wherein the porous membrane is a polypropylene microporous membrane.
Claim 12
Dependent Claim
16 words
The method of claim 8 wherein the X-ray fluorescence relative intensity range is 0.05 to 0.25.
Claim 13
Dependent Claim
19 words
The method of claim 8 wherein the X-ray fluorescence relative intensity range is in the range 0.16 to 0.20.
Claim 14
Dependent Claim
19 words
The method of claim 8 wherein the X-ray fluorescence relative intensity range is in the range 0.16 to 0.19.
Claim 15
Dependent Claim
18 words
The method of claim 8 wherein the rate is 100 ft/min and the copolymer concentration is 2% (w/w).
Claim 16
Dependent Claim
34 words
The method claim 8 wherein the triblock copolymer has polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range of 2000 to 3000.
Claim 17
Dependent Claim
25 words
A method according to claim 8 comprising the additional step of subjecting the coated membrane to ionizing radiation to produce an insoluble and adhering coating.
Claim 18
Dependent Claim
21 words
A method according to claim 15 wherein the ionizing radiation is in the form of x-rays, γ-rays or an electron beam.
Claim 19
Dependent Claim
20 words
A method according to claim 15 wherein the radiation is x-rays in the dose range of 0.25 to 13.0 Mrad.
Claim 20
Independent Claim
58 words
A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
Claim 21
Independent Claim
58 words
A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
Claim 22
Independent Claim
66 words
A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
Claim 23
Independent Claim
66 words
A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
Claim 24
Dependent Claim
15 words
A method according to claim 19 wherein the porous membrane is a polypropylene microporous membrane.
Claim 25
Dependent Claim
16 words
The method of claim 19 wherein the X-ray fluorescence relative intensity range is 0.14 to 0.22.
Claim 26
Dependent Claim
19 words
The method of claim 19 wherein the X-ray fluorescence relative intensity range is in the range 0.16 to 0.20.
Claim 27
Dependent Claim
19 words
The method of claim 19 wherein the X-ray fluorescence relative intensity range is in the range 0.1690 to 0.19.
Claim 28
Dependent Claim
18 words
The method of claim 19 wherein the rate is 100 ft/min and the copolymer concentration is 2% (w/v).
Claim 29
Dependent Claim
35 words
The method of claim 19 wherein the triblock copolymer has polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range of 2000 to 3000.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-13 | 2001-10-13 | 2002-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-13 | 2005-10-13 | 2006-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-13 | 2009-10-13 | 2010-04-14 | $7700.00 | Window Closed / Lapsed |