US5733868A
Expired / Lapsed
US
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Poly(amino acid) adhesive tissue grafts
Assignee: DePuy Orthopaedics Inc
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Filing: 1996-04-16
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Granted: 1998-03-31
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Expires: 2016-04-16
Abstract
Abstract A composition and method for repairing damaged connective tissue is provided. The composition comprises pseudo-poly(amino acids) and/or classic poly(amino acids) that exhibit adhesiveness for connective tissues. The composition is formed into an adhesive tissue repair implant and pressed against the damaged tissue to adhere the adhesive composition to the tissue.
Inventors
- 👤 Dale R. Peterson
- 👤 Samuel I. Stupp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:28
CPC Classifications
C; C09; C09J; C09J189/00; A; A61; A61L; A61L24/00; A61L24/04; A61L24/043; A61L24/10; A61L24/106
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
136 words
A pressure-sensitive adhesive composition comprising two different poly(amino acids), each of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0, and wherein X is selected from glutamate, asparagine, aspartate, and glutamine, Y is selected from lysine and arginine, and Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine, and wherein the composition exhibits an adhesiveness of about 600 to about 150,000 Pa.
Claim 2
Dependent Claim
136 words
A pressure-sensitive adhesive composition comprising two different poly(amino acids), each of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0, and wherein X is selected from glutamate, asparagine, aspartate, and glutamine, Y is selected from lysine and arginine, and Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine, and wherein the composition exhibits an adhesiveness of about 600 to about 150,000 Pa.
Claim 3
Dependent Claim
18 words
The composition of claim 1, wherein the composition is moldable at about 4° C. to about 60° C.
Claim 4
Dependent Claim
22 words
The composition of claim 1, further comprising a monomer selected from the group consisting of glutamate, aspartate, lysine, and histidine and arginine.
Claim 5
Dependent Claim
29 words
The composition of claim 1, wherein the polypeptide bears a negative charge at about physiological pH and further comprising an amino acid monomer with two or more positive charges.
Claim 6
Dependent Claim
19 words
The composition of claim 4, wherein the monomer is selected from the group consisting of lysine, arginine, or histidine.
Claim 7
Dependent Claim
29 words
The composition of claim 1, wherein the polypeptide bears a positive charge at about physiological pH and further comprising an amino acid monomer with two or more negative charges.
Claim 8
Dependent Claim
18 words
The composition of claim 6, wherein the monomer is selected from the group consisting of aspartate or glutamate.
Claim 9
Dependent Claim
10 words
The composition of claim 1, further comprising a bioactive agent.
Claim 10
Dependent Claim
155 words
A pressure-sensitive adhesive composition comprising (1) a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (b) Y is selected from lysine and arginine; and (c) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; (2) a monomer selected from the group consisting of glutamate, asparagine, aspartate, glutamine, lysine, arginine, and histidine; and (3) wherein the composition exhibits on adhesiveness of about 600 to about 150,000 Pa.
Claim 11
Dependent Claim
155 words
A pressure-sensitive adhesive composition comprising (1) a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (b) Y is selected from lysine and arginine; and (c) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; (2) a monomer selected from the group consisting of glutamate, asparagine, aspartate, glutamine, lysine, arginine, and histidine; and (3) wherein the composition exhibits on adhesiveness of about 600 to about 150,000 Pa.
Claim 12
Dependent Claim
29 words
The composition of claim 9, wherein the polypeptide bears a positive charge at about physiological pH and the monomer is selected from the group consisting of aspartate and glutamate.
Claim 13
Dependent Claim
30 words
The composition of claim 9, wherein the polypeptide bears a negative charge at about physiological pH and the monomer is selected from the group consisting of lysine, arginine, and histidine.
Claim 14
Independent Claim
174 words
A method for repairing damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising a pseudo-poly(amino acid), or a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ, wherein a, b, and c represent the respective mole fractions by the amino acids X, Y, and Z, a+b is >0, and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, or glutamine; (b) wherein if X is only aspartate, b>0; (c) wherein Y is selected from lysine or arginine; and (d) wherein Z is selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, isoleucine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 15
Independent Claim
174 words
A method for repairing damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising a pseudo-poly(amino acid), or a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ, wherein a, b, and c represent the respective mole fractions by the amino acids X, Y, and Z, a+b is >0, and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, or glutamine; (b) wherein if X is only aspartate, b>0; (c) wherein Y is selected from lysine or arginine; and (d) wherein Z is selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, isoleucine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 16
Independent Claim
187 words
A method for effecting repair of damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising (a) a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1; c<1; and a+b+c=1.0; (i) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (ii) Y is selected from lysine and arginine; and (iii) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; and (b) a monomer selected from the group consisting of glutamate, aspartate, lysine, histidine, and arginine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 17
Independent Claim
187 words
A method for effecting repair of damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising (a) a poly(amino acid) of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1; c<1; and a+b+c=1.0; (i) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (ii) Y is selected from lysine and arginine; and (iii) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; and (b) a monomer selected from the group consisting of glutamate, aspartate, lysine, histidine, and arginine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 18
Independent Claim
173 words
A method for effecting repair of damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising two different poly(amino acids), each of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (b) Y is selected from lysine and arginine; and (c) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 19
Independent Claim
173 words
A method for effecting repair of damaged connective tissue, the method comprising the steps of (1) selecting a pressure-sensitive adhesive composition comprising two different poly(amino acids), each of the formula H 2 N--Q--COOR 2 wherein Q is a divalent residue of a polypeptide formed from 1 to 3 species of amino acids, R 2 is H, a metal cation, or ammonium and wherein the amino acid components of Q are represented by the formula aX+bY+cZ wherein a, b, and c represent the respective mole fractions of the amino acids X, Y, and Z; a=0 to 1, b=0 to 1, and c<1; and a+b+c=1.0; (a) wherein X is selected from glutamate, asparagine, aspartate, and glutamine; (b) Y is selected from lysine and arginine; and (c) Z is an amino acid selected from cysteine, methionine, serine, threonine, glycine, alanine, valine, leucine, and isoleucine; (2) forming an adhesive tissue repair implant from the selected pressure-sensitive adhesive composition; and (3) pressing the tissue repair implant against the damaged tissue to adhere the adhesive composition to the tissue.
Claim 20
Dependent Claim
28 words
The method of claim 14, wherein the forming step comprises the step of maintaining the temperature of the adhesive composition at about 4° C. to about 60° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-30 | 2001-09-29 | 2002-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-30 | 2005-09-29 | 2006-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-30 | 2009-09-29 | 2010-03-31 | $7700.00 | Window Closed / Lapsed |