US5725480A
Expired / Lapsed
US
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Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds
Assignee: Abbott Laboratories
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Filing: 1996-03-06
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Granted: 1998-03-10
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Expires: 2016-03-06
Abstract
Abstract A process of calibrating an individual in preparation for the non-invasive measurement of an biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).
Inventors
- 👤 Gary M. Oosta
- 👤 Tuan A. Elstrom
- 👤 Eric B. Shain
- 👤 Thomas G. Schapira
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:27
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1495; A61B5/0059; A61B5/14532; A61B5/1455; A61B5/44; A61B5/441; A61B5/442; A61B5/443
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
115 words
A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of: (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound, wherein the skin parameters include at least one member selected from the group consisting of melanin, non-melanin chromophores, skin thickness, water content, fat content, temperature, blood flow, skin quality, skin elasticity, hair follicles, sebaceous glands, permeability, proteins, and amino acids, and wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation.
Claim 2
Dependent Claim
115 words
A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of: (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound, wherein the skin parameters include at least one member selected from the group consisting of melanin, non-melanin chromophores, skin thickness, water content, fat content, temperature, blood flow, skin quality, skin elasticity, hair follicles, sebaceous glands, permeability, proteins, and amino acids, and wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation.
Claim 3
Dependent Claim
11 words
The process of claim 1 wherein the skin parameter is melanin.
Claim 4
Dependent Claim
18 words
The process of claim 1 wherein the biological compound is selected from glucose, hemoglobin, lipids, cholesterol or protein.
Claim 5
Dependent Claim
11 words
The process of claim 3 wherein the biological compound is glucose.
Claim 6
Dependent Claim
11 words
The process of claim 1 wherein the skin parameter is melanin.
Claim 7
Dependent Claim
105 words
A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of: (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound wherein the skin parameter is melanin, wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation, and wherein the contribution of melanin to the absorption and transmittance of non-ionizing radiation is accomplished by determining the absorption and scattering coefficients of melanin.
Claim 8
Dependent Claim
105 words
A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of: (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound wherein the skin parameter is melanin, wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation, and wherein the contribution of melanin to the absorption and transmittance of non-ionizing radiation is accomplished by determining the absorption and scattering coefficients of melanin.
Claim 9
Dependent Claim
24 words
The process of claim 6 wherein the absorption and scattering coefficients of melanin are determined using diffuse reflective or frequency domain measurements of melanin.
Claim 10
Dependent Claim
11 words
The process of claim 7 wherein the biological compound is glucose.
Claim 11
Dependent Claim
19 words
The process of claim 1 wherein the correction for the biological compound is done immediately before the non-invasive measurement.
Claim 12
Dependent Claim
17 words
The process of claim 1 wherein the correction for the biological compound is stored in an instrument.
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