US5723007A
Expired / Lapsed
US
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Biocompatible composite material and process for its production
Assignee: Natural and Medical Sciences Institute
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Filing: 1996-08-08
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Granted: 1998-03-03
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Expires: 2016-08-08
Abstract
Abstract A biocompatible composite material and a method for its production are provided, wherein the composite material is made of a plastic matrix having a felt of collagen fibers contained therein, wherein the collagen fibers project out of a surface of the composite material, wherein the composite material is produced by a process involving: a) providing a collagen fiber felt wherein the collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from the surface of the composite material to expose the collagen fiber felt on the surface, wherein the composite material is useful for the production of implants, especially dental implants and the implants can be colonized with human cells prior to implantation.
Inventors
- 👤 Eva Maria Engel
- 👤 Hugo Haemmerle
- 👤 Guenter Hoff
- 👤 Otto Inacker
- 👤 Bernhard Kneissel
- 👤 Wilfried Nisch
- 👤 Lutz Scheideler
- 👤 Heiner Weber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:16
CPC Classifications
B; B32; B32B; B32B38/00; B32B38/10; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; B29; B29C; B29C70/00; B29C70/04; B29C70/06; B29C70/10; B32B9/00; B32B9/02; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61F2/24; A61F2310/00; A61F2310/00005; A61F2310/00365; B29K; B29K2089/00; B29K2105/00; B29K2105/0005; B29K2105/06; B29K2105/12; B29K2105/128; B29L; B29L2031/00; B29L2031/753; B29L2031/7532
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
112 words
A biocompatible composite material comprising a plastic matrix having a felt of collagen fibers contained therein, wherein said collagen fibers project out of a surface of said composite material, wherein the composite material is produced by a process comprising: a) providing a collagen fiber felt wherein said collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from the surface of said composite material to expose said collagen fiber felt on said surface.
Claim 2
Dependent Claim
112 words
A biocompatible composite material comprising a plastic matrix having a felt of collagen fibers contained therein, wherein said collagen fibers project out of a surface of said composite material, wherein the composite material is produced by a process comprising: a) providing a collagen fiber felt wherein said collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from the surface of said composite material to expose said collagen fiber felt on said surface.
Claim 3
Dependent Claim
26 words
The biocompatible composite material as claimed in claim 1, wherein said one or more polymerizable monomers are selected from the group consisting of acrylates and methacrylates.
Claim 4
Dependent Claim
18 words
The biocompatible composite material as claimed in claim 2, wherein said one or more polymerizable monomers are methacrylates.
Claim 5
Dependent Claim
68 words
The biocompatible composite material as claimed in claim 2, wherein said one or more polymerizable monomers are selected from the group consisting of methyl methacrylate, ethyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, 2-ethylhexyl methacrylate, cyclohexyl methacrylate, isobornyl methacrylate, tetrahydrofurfuryl methacrylate, benzyl methacrylate, morpholinoethyl methacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, diurethane dimethacrylate formed by reaction of trimethylhexamethylene diisocyanate with two mol of 2-hydroxyethyl methacrylate, isopropylidenebis-(2(3)-hydroxy-3(2)-(4-phenoxy)propyl methacrylate), and mixtures thereof.
Claim 6
Dependent Claim
21 words
The biocompatible composite material as claimed in claim 1, wherein said step c) is performed by application of heat or light.
Claim 7
Dependent Claim
30 words
The biocompatible composite material as claimed in claim 1, wherein said step d) is performed by treating said surface with acetone to remove said unpolymerized monomers and said shortchain oligomers.
Claim 8
Dependent Claim
19 words
The biocompatible composite material as claimed in claim 1, wherein said one or more polymerizable monomers is methyl methacrylate.
Claim 9
Dependent Claim
111 words
A process for the production of a biocompatible composite material comprising a plastic matrix having a collagen fiber felt contained therein, wherein said collagen fiber felt projects out of a surface of the composite material, said process comprising: a) providing a collagen fiber felt wherein said collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from a surface of said composite material to expose said collagen fiber felt on said surface.
Claim 10
Dependent Claim
111 words
A process for the production of a biocompatible composite material comprising a plastic matrix having a collagen fiber felt contained therein, wherein said collagen fiber felt projects out of a surface of the composite material, said process comprising: a) providing a collagen fiber felt wherein said collagen fibers have a structure of native collagen; b) impregnating the collagen fiber felt with one or more polymerizable monomers, c) partially curing the one or more polymerizable monomers to provide a polymer containing unpolymerized monomers, shortchain oligomers or both therein; d) removing the unpolymerized monomers and shortchain oligomers from a surface of said composite material to expose said collagen fiber felt on said surface.
Claim 11
Dependent Claim
24 words
The process as claimed in claim 8, wherein said one or more polymerizable monomers are selected from the group consisting of acrylates and methacrylates.
Claim 12
Dependent Claim
16 words
The process as claimed in claim 9, wherein said one or more polymerizable monomers are methacrylates.
Claim 13
Dependent Claim
66 words
The process as claimed in claim 9, wherein said one or more polymerizable monomers are selected from the group consisting of methyl methacrylate, ethyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, 2-ethylhexyl methacrylate, cyclohexyl methacrylate, isobornyl methacrylate, tetrahydrofurfuryl methacrylate, benzyl methacrylate, morpholinoethyl methacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, diurethane dimethacrylate formed by reaction of trimethylhexamethylene diisocyanate with two mol of 2-hydroxyethyl methacrylate, isopropylidenebis-(2(3)-hydroxy-3(2)-(4-phenoxy)propyl methacrylate), and mixtures thereof.
Claim 14
Dependent Claim
19 words
The process as claimed in claim 8, wherein said step c) is performed by application of heat or light.
Claim 15
Dependent Claim
28 words
The process as claimed in claim 8, wherein said step d) is performed by treating said surface with acetone to remove said unpolymerized monomers and said shortchain oligomers.
Claim 16
Dependent Claim
17 words
The process as claimed in claim 8, wherein said one or more polymerizable monomers is methyl methacrylate.
Claim 17
Dependent Claim
13 words
An implant produced from a biocompatible composite material as claimed in claim 1.
Claim 18
Dependent Claim
20 words
The implant as claimed in claim 15, wherein said surface having an exposed collagen fiber felt has human cells thereon.
Claim 19
Dependent Claim
17 words
The implant as claimed in claim 15, wherein said implant is colonized by human cells before implantation.
Claim 20
Dependent Claim
19 words
The implant as claimed in claim 15, wherein the implant is at least partly or completely a dental prosthesis.
References Cited (Backward Citations)
US5002583A
Cited
US5320886A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-02 | 2001-09-01 | 2002-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-02 | 2005-09-01 | 2006-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-02 | 2009-09-01 | 2010-03-03 | $7700.00 | Window Closed / Lapsed |